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Cited by 601 publications
(318 citation statements)
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“…A higher biologic effective dose to the cancer tissue may be achieved as a result of a lower ˛/ˇ ratio of the cancer compared with normal tissue. 1,10,16,17 Potentially higher doses per fraction may have additional effects over the vascular or cancer stem cells not seen with lower doses per fraction. 18 Clinical results for hypofractionated photon prostate cancer treatments have also been favorable.…”
Section: Discussionmentioning
confidence: 99%
“…A higher biologic effective dose to the cancer tissue may be achieved as a result of a lower ˛/ˇ ratio of the cancer compared with normal tissue. 1,10,16,17 Potentially higher doses per fraction may have additional effects over the vascular or cancer stem cells not seen with lower doses per fraction. 18 Clinical results for hypofractionated photon prostate cancer treatments have also been favorable.…”
Section: Discussionmentioning
confidence: 99%
“…21 Biochemical failure (BF) was assessed using the ASTRO definition. Local failure for the purpose of this study was defined as the appearance of a new nodular density on the prostate on physical examination.…”
Section: Radiation Techniquementioning
confidence: 99%
“…Sensitivity to fraction size is conveniently described by the a/b value, which is relatively high (P6 Gy) for many squamous carcinomas and early responding normal tissues compared to late responding normal tissues (a/b values <6 Gy). This relationship does not apply to all tumour types, with evidence that adenocarcinomas of the breast and prostate are more sensitive to fraction size than previously thought [2]. An a/b value of 4-5 Gy was first estimated for locally advanced and recurrent breast cancer by Douglas in the mid-1980s based on clinical data published by Cohen in early 1950s [3,4].…”
Section: Introductionmentioning
confidence: 99%