2008
DOI: 10.1159/000139661
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Abstract: Background: Although the clinical significance of so-called microbleeds (MBs) in gradient-echo MR images (GRE-MRI) has been extensively researched, the histopathological evaluation is notably insufficient. Methods: Postmortem GRE-MRI was obtained of water-immersed formalin-fixed tissue blocks from a 97-year-old hypertensive woman with 9 antemortem MBs. Histologic slides were compared with those of MRI. Results: Microscopic examination revealed clusters of hemosiderin-laden macrophages in 8 MBs and arteriolar p… Show more

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Cited by 79 publications
(59 citation statements)
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References 15 publications
(8 reference statements)
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“…20,21 Pathology studies showed that BMBs consist of hemosiderin deposits from blood that presumably leaked from small blood vessels that are affected by lipohyalinosis in most subjects. [22][23][24] In some cases with mainly lobar BMBs, evidence of amyloid angiopathy was found. 24 These data, though limited, suggest that deep and lobar BMBs represent different underlying pathologies, analogous to symptomatic intracerebral hemorrhage.…”
Section: Mri Scoringmentioning
confidence: 99%
“…20,21 Pathology studies showed that BMBs consist of hemosiderin deposits from blood that presumably leaked from small blood vessels that are affected by lipohyalinosis in most subjects. [22][23][24] In some cases with mainly lobar BMBs, evidence of amyloid angiopathy was found. 24 These data, though limited, suggest that deep and lobar BMBs represent different underlying pathologies, analogous to symptomatic intracerebral hemorrhage.…”
Section: Mri Scoringmentioning
confidence: 99%
“…It was shown that the deep cerebellar region around the dentate nucleus, as well as the pons, thalamus and basal ganglia, is a predilection site for cerebral microbleeds [28]. Hypertensive intracerebral hemorrhage and cerebral microbleeds share a common pattern of lesion distribution and pathologic findings with ischemic small-vessel disease [18, 29, 30], and there is a correlation between the severity of lacunes, leukoaraiosis and microbleeds in hypertensive patients [18, 31, 32]. These findings suggest that lacunar infarction as well as microbleeds and hypertensive intracerebral hemorrhage could develop in the deep cerebellum.…”
Section: Discussionmentioning
confidence: 99%
“…2,3 Cerebral microbleeds (MBs) are seen as hypointense lesions on gradient echo or susceptibility-weighted imaging. 4,5 They occur in 4.7% to 23.5% of the general population, frequently in lobar locations, 6,7 and may reflect amyloid angiopathy. These MRI lesions are manifestations of subclinical cerebrovascular disease and tend to occur together commonly.…”
mentioning
confidence: 99%