Direct analysis in real time – High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development

Srbek, Jan; Klejdus, Bořivoj; Douša, Michal; Břicháč, Jiří; Stasiak, Pawel; Reitmajer, Josef; Nováková, Lucie

doi:10.1016/j.talanta.2014.07.007

Cited by 26 publications

(12 citation statements)

References 26 publications

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“…Over the last decade, the application field of the DART-MS technique has seen extraordinary expansion. The technique has gained popularity among researchers and has been considered suitable for the following: olive oil authenticity assessment [36], pesticide monitoring on fruits [37] and vegetables [38], metabolite fingerprinting [39], plant seed characterization [40], clinical [35], pharmaceutical [41], forensic [42] and environmental [43] analyses, and for the detection of adulteration in foods such as milk [44] and honey [45].…”

Section: Analytical Techniquesmentioning

confidence: 99%

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Pérez-Rodríguez

Pellerano

Pezza

et al. 2018

Talanta

137

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Tetracyclines are widely used for both the treatment and prevention of diseases in animals as well as for the promotion of rapid animal growth and weight gain. This practice may result in trace amounts of these drugs in products of animal origin, such as milk and eggs, posing serious risks to human health. The presence of tetracycline residues in foods can lead to the transmission of antibiotic-resistant pathogenic bacteria through the food chain. In order to ensure food safety and avoid exposure to these substances, national and international regulatory agencies have established tolerance levels for authorized veterinary drugs, including tetracycline antimicrobials. In view of that, numerous sensitive and specific methods have been developed for the quantification of these compounds in different food matrices. One will note, however, that the determination of trace residues in foods such as milk and eggs often requires extensive sample extraction and preparation prior to conducting instrumental analysis. Sample pretreatment is usually the most complicated step in the analytical process and covers both cleaning and pre-concentration. Optimal sample preparation can reduce analysis time and sources of error, enhance sensitivity, apart from enabling unequivocal identification, confirmation and quantification of target analytes. The development and implementation of more environmentally friendly analytical procedures, which involve the use of less hazardous solvents and smaller sample sizes compared to traditional methods, is a rapidly increasing trend in analytical chemistry. This review seeks to provide an updated overview of the main trends in sample preparation for the determination of tetracycline residues in foodstuffs. The applicability of several extraction and clean-up techniques employed in the analysis of foodstuffs, especially milk and egg samples, is also thoroughly discussed.

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Section: Analytical Techniquesmentioning

confidence: 99%

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Pérez-Rodríguez

Pellerano

Pezza

et al. 2018

Talanta

137

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“…The pharmaceutical products in the form of tablet are generally analyzed using this strategy, and various active pharmaceutical ingredients in different pharmaceutical tablets [39,56,[65][66][67][68] as well as impurity D in atorvastatin tablet [68] were successfully analyzed and investigated. In addition, several raw herbal materials including Atropa acuminate [69], Piper betle Linn [70], Ocimum basilicum, Mentha spicata, and Coriandrum sativum [71], Aconitum plants [72], Datura seeds [73], and Rauwolfia species [74] were also analyzed by DART-MS via such a strategy.…”

Section: Direct Analysis In Real Timementioning

confidence: 99%

“…TLC-DART-MS was successfully applied for analysis of pharmaceutical drugs [68,92], forensic drugs [92], and herbal medicines of Angelica gigas, Evodia rutaecarpa, and Schisandra chinensis [93]. Quantitative analysis of major dibenzocyclooctane lignans in Schisandra chinensis by online TLC-DART-MS were also done by Kim et al [94].…”

Section: Direct Analysis In Real Timementioning

confidence: 99%

“…Mey. Ginsenoside Rb 2 /b 3 /R c , Rb 1 , Rd, Re, Rg 1 , notoginsenosides R 1 , F 2 , pseudoginsenoside F11, compound K, protopanaxadiol, protopanaxatriol Danshen injection Protocatechuic aldehyde, salvianolic acid A, salvianolic acid C, and fructose, glucose, sucrose [87] Danshen alkaline precipitation Caffeic acid, salvianic acid A, protocatechuic aldehyde, fructose, glucose [88] Preparation of Sophora flavescens and Heterosmilax japonica Kunth Matrine, N, N-methylcytisine, oxymatrine, oxysophocarpine, sophocarpine, fructose, glucoseIn house active pharmaceutical ingredients Bosentan, clopidogrel, esomeprazole, ibuprofen, mirtazapin, ofloxacin[68] …”

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confidence: 99%

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Analysis of pharmaceutical products and herbal medicines using ambient mass spectrometry

Yang

Deng

2016

TrAC Trends in Analytical Chemistry

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“…[1] Methods for forming ions under ambient conditions can be classified into three primary groups that are based on liquid solution sprays, [2,3] laser desorption from surfaces, [4][5][6] and plasma ionization. [7] Such ionization methods can be used to analyse samples in the open atmosphere without the need for ion source enclosure, which facilitates high-throughput screening applications, including in the analysis of pharmaceutical tablets, [8] forensic samples, [9][10][11] explosives, [12,13] narcotics, [14] chemical warfare agents, [15][16][17] and persistent organic pollutants, [18][19][20] and bacterial profiling. [21] Plasma-based ionization methods have the advantages that (i) solvents, fluid pumps, and lasers are not required, and (ii) such ion sources tend to be significantly less susceptible to ion suppression, in which the sample matrix can detrimentally affect analyte ionization efficiency, than spray-and laser-based ion sources.…”

Section: Introductionmentioning

confidence: 99%

Internal Energy Deposition in Dielectric Barrier Discharge Ionization is Significantly Lower than in Direct Analysis in Real-Time Mass Spectrometry

2017

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The extent of internal energy deposition using three different plasma-based ionization mass spectrometry (MS) methods, atmospheric pressure chemical ionization (APCI), direct analysis in real time (DART), and active capillary dielectric barrier discharge ionization (DBDI), was investigated using benzylammonium 'thermometer' ions. Ions formed by DBDI were activated significantly less than those that were formed by DART and APCI under these conditions. Thermal ion activation by DART can be reduced slightly by positioning the DART source further from the capillary entrance to the MS and reducing the heat that is applied to metastable atoms exiting the DART source. For example, the average ion internal energy distribution decreased by less than 10 % (166.9 AE 0.3 to 152.2 AE 1.0 kJ mol À1) when the distance between the DART source and the MS was increased by 250 % (10 to 25 mm). By lowering the DART temperature from 350 to 1508C, the internal energy distributions of the thermometer ions decreased by ,15 % (169.93 AE 0.83 to 150.21 AE 0.52 kJ mol À1). Positioning the DART source nozzle more than 25 mm from the entrance to the MS and decreasing the DART temperature further resulted in a significant decrease in ion signal. Thus, varying the major DART ion source parameters had minimal impact on the 'softness' of the DART ion source under these conditions. Overall, these data indicate that DBDI can be a significantly 'softer' ion source than two of the most widely used plasma-based ion sources that are commercially available.

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Direct analysis in real time – High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development

Cited by 26 publications

References 26 publications

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

An overview of the main foodstuff sample preparation technologies for tetracycline residue determination

Analysis of pharmaceutical products and herbal medicines using ambient mass spectrometry

Internal Energy Deposition in Dielectric Barrier Discharge Ionization is Significantly Lower than in Direct Analysis in Real-Time Mass Spectrometry

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