Direct-acting antivirals for chronic hepatitis C

Jakobsen, Janus Christian; Nielsen, Emil Eik; Feinberg, Joshua; Katakam, Kiran Kumar; Fobian, Kristina; Hauser, Goran; Poropat, Goran; Djurisic, Snezana; Weiss, Karl Heinz; Bjelaković, Marija; Bjelaković, Goran; Klingenberg, Sarah Louise; Liu, Jianping; Nikolova, Dimitrinka; Koretz, Ronald L.; Gluud, Christian

doi:10.1002/14651858.cd012143.pub2

Cited by 102 publications

(64 citation statements)

References 333 publications

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“…4 Despite some recent controversial results from a Cochrane meta-analysis, which was unable to determine the effect of DAAs on hepatitis C-related morbidity and all-cause mortality, data from observational studies and trials using surrogate outcomes show that modern pan-genotypic DAA regimens are efficacious against HCV-related morbidity and mortality, also in patients with early fibrosis/non-advanced liver disease. 5,6 Notwithstanding, HCV prevalence is declining in the general population, HCV incidence is increasing between special populations such as persons who injects drugs (PWID), men who have sex with men (MSM) and prisoners. In this article, we will review the perspective of HCV eradication, es- in the target 3.3 stated: "…end the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases and combat hepatitis, water-borne diseases and other communicable diseases…".…”

Section: Introductionmentioning

confidence: 99%

Hepatitis C: Is eradication possible?

Lombardi

Mondelli

2019

Liver International

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Hepatitis C has a relevant global impact in terms of morbidity, mortality and economic costs, with more than 70 million people infected worldwide. In the resolution, “Transforming our world: the 2030 Agenda for Sustainable Development” was included as a focus area in the health‐related goal with world leaders pledging to “combat” it by 2030. In response, WHO drafted the Global Viral Hepatitis Strategy carrying the ambitious targets to reduce the number of deaths by two‐thirds and to increase treatment rates up to 80%. Despite the availability of highly effective therapeutic regimens based on direct‐acting antivirals many barriers to HCV eradication still remain. They are related to awareness of the infection, linkage to care, availability of the therapeutic drug regimens and reinfection. Overall, if an effective prophylactic vaccine will not be available, HCV eradication appears difficult to achieve in the future.

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Section: Introductionmentioning

confidence: 99%

Hepatitis C: Is eradication possible?

Lombardi

Mondelli

2019

Liver International

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“…Direktni antivirusni lijekovi 7 Cochrane sustavni pregled primjene direktnih antivirusnih lijekova u liječenju kroničnog hepatitisa C predstavlja zajednički recentan rad koji je u trenutku pisanja ovog preglednog članka u postupku publikacije. Plod je suradnje više autora iz različi-tih europskih zemalja pod okriljem Cochrane hepatobilijarne grupe u koji su uključeni i članovi naše Cochrane grupe.…”

Section: Pegilirani Interferon I Ribavirinunclassified

Riječka Cochrane grupa – prikaz aktivnosti i rezultata

et al. 2017

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Sažetak. Dugogodišnja suradnja riječkih gastroenterologa sa specifičnim grupama u sklopu Cochrane kolaboracije rezultirala je značajnim napretkom na polju znanstveno-istraživačke djelatnosti i brojnim publikacijama. Spoznaje i zaključci dosegnuti u sustavnim pregledima Cochrane predstavljaju pouzdane stručne dokaze u raznim područjima gastroenterologije, posebno kronične hepatitis C infekcije, kolestatskih bolesti jetre i akutnog pankreatitisa. Navedene publikacije visoko su citirani radovi, koji su implementirani i u nekim međunarodnim smjernicama, odnosno preporukama liječenja. Doprinosom riječke Cochrane grupe otvorena su vrata suradnje s brojnim inozemnim stručnjacima i suradnicima, pokrenuto je organiziranje tečajeva medicine temeljene na dokazima i unaprijeđena je suradnja s Hrvatskim Cochrane centrom te drugim domaćim znanstvenicima. Ovaj pregledni članak predstavlja pregled dosadašnjih postignuća riječkih autora u sklopu Cochrane kolaboracije uz sažet prikaz najznačajnijih rezultata i zaključaka u objavljenim Cochrane sustavnim pregledima s ciljem upoznavanja javnosti s mogućnostima rada u Cochrane kolaboraciji i vrstom znanstveno-istraživačke djelatnosti koja se u njenom okrilju provodi te promocije i popularizacije medicine temeljene na dokazima u široj znanstvenoj i stručnoj zajednici.Ključne riječi: Cochrane kolaboracija; medicina temeljena na dokazima; metaanaliza; sustavni pregled Abstract. The long-term cooperation of gastroenterologists from Rijeka with specific groups within the Cochrane Collaboration has achieved a significant progress in the field of scientific research and numerous publications. The findings and conclusions reached in the published Cochrane systematic reviews represent reliable evidence in various gastroenterology fields, particularly chronic hepatitis C infection, cholestatic liver disease and acute pancreatitis. The mentioned publications are highly quoted papers, which are cited in different international guidelines and treatment recommendations. The contribution of authors from Rijeka, started a cooperation with several foreign experts and associates. Courses in evidence-based medicine have been organized, and the collaboration with the Croatian Cochrane Center and other Croatian scientists has been enhanced. This review article presents an overiew of the achievements of authors from Rijeka within the Cochrane Collaboration with a summary of the most important results and conclusions from the systematic reviews aiming to inform the public about the opportunities given by the Cochrane Collaboration and the type of scientific research implemented by it, as well as, to promote and popularize evidence-based medicine in a broad scientific and professional community.

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“…Late viral relapses are extremely rare after successful treatment with DAAs . However, a recent exhaustive systematic review underlined the absence of evidence to determine the effect of sustained viral response on long‐term outcome . Regarding neurobiological consequences, it has been suggested that the infected microglial cells may increase secretion of pro‐inflammatory cytokines such as tumour necrosis factor‐α (TNF‐α) or interleukins (IL), which have been associated with the physiopathology of depressive and cognitive symptoms …”

Section: Introductionmentioning

confidence: 99%