Dipyridamole recognition and controlled release by uniformly sized molecularly imprinted nanospheres

Esfandyari-Manesh, Mehdi; Javanbakht, Mehran; Atyabi, Fatemeh; Mohammadi, Ali; Mohammadi, Somayeh; Akbari‐adergani, Behrouz; Dinarvand, Rassoul

doi:10.1016/j.msec.2011.07.019

Cited by 47 publications

(29 citation statements)

References 34 publications

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“…Esfandyari-Manesh et al reported a synthetic condition of precipitation polymerization to obtain uniformly sized molecularly imprinted nanospheres of dipyridamole for application in the design of new drug delivery systems [87]. In addition, the morphology, drug release, and binding properties of MIPs were studied, and the eff ects of morphology on other properties were investigated.…”

Section: Nanospherementioning

confidence: 99%

Combination of Molecular Imprinting and Nanotechnology: Beginning of a New Horizon

Madhuri

Roy

Gupta

et al. 2014

Advanced Biomaterials and Biodevices

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Th e molecular imprinting technology provides a distinctive prospect for the creation of three-dimensional cavities, which mimic biological recognition. Over the last decade, substantial eff ort has been devoted from the micro to nanoscale to develop variety of polymeric formats that are compatible with molecular imprinting technology with the aim of emerging a variety of novel synthetic receptors. Th is advancement has off ered considerable advantages, such as greater surfaceto-volume ratio, accessibility to the maximum number of recognition sites, lower diff usion times to facilitate greater uptake and release of the template and overall improved effi ciency. In addition to these, there are also benefi ts related to the distinct diff erences in properties (optical, electrical, mechanical, etc.) demonstrated by nanomaterials when compared with their macroscopic counterparts. In response to this, a new generation of molecularly imprinted synthetic receptors has arisen over the past decade that display physical properties, which are oft en closer to those demonstrated by enzymes and antibodies, such as physical size, solubility, fl exibility and recognition site accessibility. In this chapter, we like to focus on the recent development in the fi eld of craft ing recognition sites on nanostructured materials and/or designing imprinted materials at nanoscale and their consequences for the common mankind.

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Section: Nanospherementioning

confidence: 99%

Combination of Molecular Imprinting and Nanotechnology: Beginning of a New Horizon

Madhuri

Roy

Gupta

et al. 2014

Advanced Biomaterials and Biodevices

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“…This scheme as MISPE allows the simple, sensitive, and inexpensive extraction of the analyte in biological and mixture samples. Recently, we also applied MIPs as synthetic artificial receptors in potentiometric detection of hydroxyzine [33] and cetirizine [34], solid-phase extraction of verapamil [35], metoclopramide [36], tramadol [37] and dextromethorphan [38] from complex biological fluids, and sustained release of dipyridamole [39,40]. Present research explains the significance of using molecular imprinted polymers as novel sorbent materials for extraction of drugs which are prepared by microorganisms in pharmaceutical manufactures from fermentation broth.…”

Section: Introductionmentioning

confidence: 99%

Extraction and purification of penicillin G from fermentation broth by water-compatible molecularly imprinted polymers

Javanbakht

Pishro

Nasab

et al. 2012

Materials Science and Engineering: C

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“…10 Because of their unique performance, they have been widely used as SPE absorbents, 11 sensors, 12 and catalysts, 13 and for drug-controlled release 14 and chiral separation. 21 Among the above methods, precipitation polymerization is probably the most facile synthetic method without the use of a surfactant. 19 However, MIPs prepared by bulk polymerization need grinding and sieving, which is a labor intensive and wasteful process.…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted solid-phase extraction coupled with gas chromatography for the determination of four chloroacetamide herbicides in soil

et al. 2015

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A molecularly imprinted solid phase extraction (MISPE) coupled with gas chromatography (GC) for the simultaneous separation and determination of four chloroacetamide herbicides, alachlor, acetochlor, pretilachlor and metolachlor, in soil was developed. Molecularly imprinted polymers (MIPs) with butachlor as the dummy template were synthesized via precipitation polymerization, where methacrylic acid (MAA) was used as the functional monomer, ethylene glycol dimethacrylate (EDMA) as the crosslinker and acetonitrile as the porogen. Fourier-transform infrared spectrometry (FTIR) and scanning electron microscopy (SEM) were used to characterize the polymers. Under the optimum SPE conditions, the polymer sorbents can selectively extract and enrich alachlor, acetochlor, pretilachlor and metolachlor. A comparison experiment also showed that the MISPE cartridges were better than the nonimprinted and C18 cartridges in terms of recovery. The mean recoveries of the four chloroacetamide herbicides from blank soil spiked at 0.1, 0.5, and 1 mg mL À1 ranged between 80.6 and 90.2% with relative standard deviations (RSD) of less than 8% (n ¼ 5). The limit of detection (LOD) and the limit of quantification (LOQ) of the four analytes were in the range of 1.0 Â 10 À12 to 5 Â 10 À11 g and 0.0005-0.025 mg kg À1 , respectively. The presented MISPE-GC method exhibited highly selective separation and enrichment of trace chloroacetamide herbicides and could be potentially applied to the determination of chloroacetamide herbicides in soil.

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Dipyridamole recognition and controlled release by uniformly sized molecularly imprinted nanospheres

Cited by 47 publications

References 34 publications

Combination of Molecular Imprinting and Nanotechnology: Beginning of a New Horizon

Combination of Molecular Imprinting and Nanotechnology: Beginning of a New Horizon

Extraction and purification of penicillin G from fermentation broth by water-compatible molecularly imprinted polymers

Molecularly imprinted solid-phase extraction coupled with gas chromatography for the determination of four chloroacetamide herbicides in soil

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