Diprenorphine, an antagonist of opioid analgesia, elicits a positive affective state in rats

Beaman, Carol M.; Hunter, George A.; Reid, Larry D.

doi:10.3758/bf03333841

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Each point represents data from six to eight mice. *P<0.05, versus saline-treated controls (Wilcoxon's rank-sum test) Schechter and Calcagnetti 1993;see, however, Phillips and LePiane 1980;Bozarth and Wise 1981;Beaman et al 1984;Mucha and Iversen 1984). Strain differences in place preference conditioning were previously demonstrated in mice conditioned with morphine (Semenova et al 1995).…”

Section: Discussionmentioning

confidence: 82%

Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice

et al. 1999

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Drug administration during test trials can increase the expression of place conditioning, offering an opportunity to determine the specificity of this enhanced response. Prior to training, Swiss-Webster mice spent similar durations in each of the distinctive compartments of a two-compartment box during three 900-s tests. During a 4-day conditioning period, daily injections of morphine (5-20 mg/kg, SC) or vehicle were differentially paired with one of two compartments of the box using an unbiased place conditioning procedure. Post-conditioning tests were conducted 2 and 3 days after the last conditioning day. Mice pre-treated during post-conditioning tests with vehicle did not show significant preference for the morphine-paired compartment when conditioned with morphine. Pretreatment with morphine (2.5-30 mg/kg, SC) led to a dose-dependent increase in time spent in the morphine-paired compartment. Post-conditioning tests in other groups of mice were conducted with heroin (0.1-3 mg/kg), fentanyl (0.01-0.3 mg/kg), cocaine (10-30 mg/kg) and pentobarbital (10-30 mg/kg), and results suggested that none of the tested drugs facilitated the expression of the morphine-conditioned place preference. In another experiment, naltrexone (0.1-10 mg/kg, SC) was administered as the conditioning drug. When tested with naltrexone (0.1-10 mg/kg), there was a dose-dependent avoidance of the naltrexone-paired compartment. Overall, the present data indicated that: (1) failure to exhibit place preference or place aversion when tested in a drug-free state does not imply the failure of conditioning procedure; and (2) effects of the morphine cue reinstatement during the post-conditioning tests appeared to be related to the unique pharmacological profile of the morphine stimulus.

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Section: Discussionmentioning

confidence: 82%

Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice

et al. 1999

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“…(3) Some opioids, for example, DIP, that are antagonists to analgesia show other signs of eliciting positive affect (Beaman et al, 1984).…”

Section: Resultsmentioning

confidence: 99%

“…In many in vitro bioassays, DIP acts as an antagonist. Yet, in the intact rat, DIP leads to increased pressing for ICS and is capable of establishing a conditioned place preference (Beaman, Hunter, & Reid, 1984;Pollerberg, Costa, Shearman, Herz, & Reid, 1983). Although DIP and naloxone (the prototypic antagonist at opioceptors) share the ability to block opioid analgesia, they produce different effeets with respect to pressing for ICS.…”

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confidence: 99%

Morphine and diprenorphine together potentiate responding for positively reinforcing brain stimulation

et al. 1987

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Tests Involving Pressing for Intracranial Stimulation as an Early Procedure for Screening Likelihood of Addiction of Opioids and Other Drugs

Reid

1987

Methods of Assessing the Reinforcing Properties of Abused Drugs

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Diprenorphine, an antagonist of opioid analgesia, elicits a positive affective state in rats

Cited by 6 publications

References 10 publications

Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice

Effects of test conditions on the outcome of place conditioning with morphine and naltrexone in mice

Morphine and diprenorphine together potentiate responding for positively reinforcing brain stimulation

Tests Involving Pressing for Intracranial Stimulation as an Early Procedure for Screening Likelihood of Addiction of Opioids and Other Drugs

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