Diphenyl diselenide and diphenyl ditelluride differentially affect δ‐aminolevulinate dehydratase from liver, kidney, and brain of mice

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

“…The selected dose of both chalcogens was based on our previous report (Maciel et al, 2000), where we tested different doses for acute and chronic exposure. Similarly, in the same dose range, diphenyl diselenide has been reported to have interesting pharmacological effects, such as antinoception and antiinflammatory effects, among others, (see, for instance : Savegnago et al, 2008;Savegnago et al, 2007a;Savegnago et al,2007b andSavegnago et al,2006).…”

“…The nanoenzyme showed higher efficiency and provided a platform for the synthesis and designing of polymeric nanoparticles as excellent model of enzyme mimics (Huang et al, 2008). Organotellurium vitro models of animal pathologies (Maciel et al, 2000;Taylor, 1996;Stangherlin et al, 2009;Moretto et al, 2007;Heimfarth et al, 2011;Heimfarth et al, 2012 b;Comparsi et al, 2012).…”

“…After 48 hours of diselenide or ditelluride treatment, mice did not show symptoms of toxicity such as stereotypical behavior, ataxia, diarrhea, increased dieresis or abdominal writings. However, after 96 hours, the group treated with (PhTe)2 presented diarrhea, low level of motor activity and a decrease in body weight (data not shown); which is in accordance with previous finding from our laboratory (Maciel et al 2000).…”

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

“…The selected dose of both chalcogens was based on our previous report (Maciel et al, 2000), where we tested different doses for acute and chronic exposure. Similarly, in the same dose range, diphenyl diselenide has been reported to have interesting pharmacological effects, such as antinoception and antiinflammatory effects, among others, (see, for instance : Savegnago et al, 2008;Savegnago et al, 2007a;Savegnago et al,2007b andSavegnago et al,2006).…”

“…The nanoenzyme showed higher efficiency and provided a platform for the synthesis and designing of polymeric nanoparticles as excellent model of enzyme mimics (Huang et al, 2008). Organotellurium vitro models of animal pathologies (Maciel et al, 2000;Taylor, 1996;Stangherlin et al, 2009;Moretto et al, 2007;Heimfarth et al, 2011;Heimfarth et al, 2012 b;Comparsi et al, 2012).…”

“…After 48 hours of diselenide or ditelluride treatment, mice did not show symptoms of toxicity such as stereotypical behavior, ataxia, diarrhea, increased dieresis or abdominal writings. However, after 96 hours, the group treated with (PhTe)2 presented diarrhea, low level of motor activity and a decrease in body weight (data not shown); which is in accordance with previous finding from our laboratory (Maciel et al 2000).…”

δ‐Aminolevulinate Dehydratase Inhibition by Phenyl Selenoacetylene: Effect of Reaction with Hydrogen Peroxide

“…Present results corroborate previous findings from our group indicating that due to its sulfhydrylic nature δ‐aminolevulinate dehydratase may be a potential molecular target for selenium intoxication (Barbosa et al 1998; Maciel et al 2000, Farina et al 2001; Jacques‐Silva et al 2001). δ‐Aminolevulinate dehydratase inhibition by selenium compounds would be expected to cause impairment in haem biosynthesis.…”

Acute administration of the organochalcogen 3‐methyl‐1‐phenyl‐2‐(phenylseleno)oct‐2‐en‐1‐one induces biochemical and hematological disorders in male rats

“…In fact, reduced cysteinyl residues from proteins also can react with these compounds, which may cause, in the case of the enzymes, the loss of their catalytic activity 16,22 . The impairment of the activity of sulfhydryl enzymes, such as δ ‐aminolevulinate‐dehydratase ( δ ‐ALA‐D), may impair heme biosynthesis and possibly cause an unbalance of cellular heme‐dependent metabolic pathways, decreasing the production of hemoglobin 17,29,30 . Because Se have a high affinity for SH groups on proteins and other endogenous biomolecules, we may infer that this organoselenium compound decreased hemoglobin in our treated rats by interference on this route.…”

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

“…The selected dose of both chalcogens was based on our previous report (Maciel et al, 2000), where we tested different doses for acute and chronic exposure. Similarly, in the same dose range, diphenyl diselenide has been reported to have interesting pharmacological effects, such as antinoception and antiinflammatory effects, among others, (see, for instance : Savegnago et al, 2008;Savegnago et al, 2007a;Savegnago et al,2007b andSavegnago et al,2006).…”

“…The nanoenzyme showed higher efficiency and provided a platform for the synthesis and designing of polymeric nanoparticles as excellent model of enzyme mimics (Huang et al, 2008). Organotellurium vitro models of animal pathologies (Maciel et al, 2000;Taylor, 1996;Stangherlin et al, 2009;Moretto et al, 2007;Heimfarth et al, 2011;Heimfarth et al, 2012 b;Comparsi et al, 2012).…”

“…After 48 hours of diselenide or ditelluride treatment, mice did not show symptoms of toxicity such as stereotypical behavior, ataxia, diarrhea, increased dieresis or abdominal writings. However, after 96 hours, the group treated with (PhTe)2 presented diarrhea, low level of motor activity and a decrease in body weight (data not shown); which is in accordance with previous finding from our laboratory (Maciel et al 2000).…”

δ‐Aminolevulinate Dehydratase Inhibition by Phenyl Selenoacetylene: Effect of Reaction with Hydrogen Peroxide

“…Present results corroborate previous findings from our group indicating that due to its sulfhydrylic nature δ‐aminolevulinate dehydratase may be a potential molecular target for selenium intoxication (Barbosa et al 1998; Maciel et al 2000, Farina et al 2001; Jacques‐Silva et al 2001). δ‐Aminolevulinate dehydratase inhibition by selenium compounds would be expected to cause impairment in haem biosynthesis.…”

Acute administration of the organochalcogen 3‐methyl‐1‐phenyl‐2‐(phenylseleno)oct‐2‐en‐1‐one induces biochemical and hematological disorders in male rats

“…In fact, reduced cysteinyl residues from proteins also can react with these compounds, which may cause, in the case of the enzymes, the loss of their catalytic activity 16,22 . The impairment of the activity of sulfhydryl enzymes, such as δ ‐aminolevulinate‐dehydratase ( δ ‐ALA‐D), may impair heme biosynthesis and possibly cause an unbalance of cellular heme‐dependent metabolic pathways, decreasing the production of hemoglobin 17,29,30 . Because Se have a high affinity for SH groups on proteins and other endogenous biomolecules, we may infer that this organoselenium compound decreased hemoglobin in our treated rats by interference on this route.…”

Differential genotoxicity of diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2

“…The selected dose of both chalcogens was based on our previous report (Maciel et al, 2000), where we tested different doses for acute and chronic exposure. Similarly, in the same dose range, diphenyl diselenide has been reported to have interesting pharmacological effects, such as antinoception and antiinflammatory effects, among others, (see, for instance : Savegnago et al, 2008;Savegnago et al, 2007a;Savegnago et al,2007b andSavegnago et al,2006).…”

“…The nanoenzyme showed higher efficiency and provided a platform for the synthesis and designing of polymeric nanoparticles as excellent model of enzyme mimics (Huang et al, 2008). Organotellurium vitro models of animal pathologies (Maciel et al, 2000;Taylor, 1996;Stangherlin et al, 2009;Moretto et al, 2007;Heimfarth et al, 2011;Heimfarth et al, 2012 b;Comparsi et al, 2012).…”

“…After 48 hours of diselenide or ditelluride treatment, mice did not show symptoms of toxicity such as stereotypical behavior, ataxia, diarrhea, increased dieresis or abdominal writings. However, after 96 hours, the group treated with (PhTe)2 presented diarrhea, low level of motor activity and a decrease in body weight (data not shown); which is in accordance with previous finding from our laboratory (Maciel et al 2000).…”

δ‐Aminolevulinate Dehydratase Inhibition by Phenyl Selenoacetylene: Effect of Reaction with Hydrogen Peroxide

“…Present results corroborate previous findings from our group indicating that due to its sulfhydrylic nature δ‐aminolevulinate dehydratase may be a potential molecular target for selenium intoxication (Barbosa et al 1998; Maciel et al 2000, Farina et al 2001; Jacques‐Silva et al 2001). δ‐Aminolevulinate dehydratase inhibition by selenium compounds would be expected to cause impairment in haem biosynthesis.…”

Acute administration of the organochalcogen 3‐methyl‐1‐phenyl‐2‐(phenylseleno)oct‐2‐en‐1‐one induces biochemical and hematological disorders in male rats

“…In fact, reduced cysteinyl residues from proteins also can react with these compounds, which may cause, in the case of the enzymes, the loss of their catalytic activity 16,22 . The impairment of the activity of sulfhydryl enzymes, such as δ ‐aminolevulinate‐dehydratase ( δ ‐ALA‐D), may impair heme biosynthesis and possibly cause an unbalance of cellular heme‐dependent metabolic pathways, decreasing the production of hemoglobin 17,29,30 . Because Se have a high affinity for SH groups on proteins and other endogenous biomolecules, we may infer that this organoselenium compound decreased hemoglobin in our treated rats by interference on this route.…”