Biochemical Pharmacology volume 77, issue 4, P660-669 2009 DOI: 10.1016/j.bcp.2008.10.030 View full text
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Ryuta Ishimura, Takashige Kawakami, Seiichiroh Ohsako, Chiharu Tohyama

Abstract: Arylhydrocarbon receptor (AhR) activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) triggers its downstream signaling pathway to exert adverse effects on vasculature development, which can be initiated by vasculogenesis, followed by angiogenesis, or vascular remodeling, in a variety of animals including avians, piscines and mammals. The placenta, a mammalian organ rich in vasculature, consists of endothelial and trophoblast cells of fetal origin, which proliferate and differentiate under hypoxic condition i…

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