Archives of Dermatology
 1988
DOI: 10.1001/archderm.124.3.396
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Dinitrochlorobenzene is inherently mutagenic in the presence of trace mutagenic contaminants

Michael G. Wilkerson1
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Cited by 11 publications

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“…9 Although topical DNCB has also been used for cutaneous metastatic melanoma, 10 DPCP is thought to carry less risk of mutagenicity. 11 We now report our findings in seven melanoma patients treated with topical DPCP alone.…”
Section: Introductionmentioning
confidence: 79%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…9 Although topical DNCB has also been used for cutaneous metastatic melanoma, 10 DPCP is thought to carry less risk of mutagenicity. 11 We now report our findings in seven melanoma patients treated with topical DPCP alone.…”
Section: Introductionmentioning
confidence: 79%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…1 Diphenylcyclopropenone and squaric acid dibutyl ester have been commonly used as contact allergens for treatment, whereas dinitrochlorobenzene is no longer used because of its mutagenicity. 6 As potent contact allergens, these agents exert their therapeutic effects by inducing allergic contact dermatitis on the scalp. 4 As a result, adverse effects, such as erythema, pruritus, eczema, and lymphadenopathy, frequently accompany the treatment, and careful monitoring of patients is needed throughout treatment.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…They all had an almost full head of hair when I saw them and none of them had ever wanted to stop DNCB even though we reminded them yearly of the risk for lymphoma. This potential of a cancer was brought about by a test called the Ames test where DNCB was found to be mutagenic in bacteria . Most of these patients had been with Dr. Muller for about 20–25 years or more.…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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