Diminished immune response in sun-damaged skin

O'Dell, B. L.

doi:10.1001/archderm.116.5.559

Cited by 23 publications

(5 citation statements)

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“…DTH measure antigen-specific responses following vaccination. In reported human studies, UV exposure was given after exposure or infection 139 , and like CHS, suppression of elicitation reactions occurs at both local and distant unirradiated sites 133,140 . Interestingly, UVB-mediated suppression of CHS positively correlates with a prior history of skin cancer 141 , and UV-induced immunosuppression is enhanced in males which may explain the increased incidence and risk of mortality in skin cancers in men 142 .…”

Section: Clinical Studies Linking Immunosuppression With Skin Cancermentioning

confidence: 99%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

164

147

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Over the past several decades, there has been increasing interest in understanding the roles of the immune system in the development and progression of cancer. The importance of the immune system in human skin cancer has been long recognised based primarily upon the increased incidence of skin cancers in organ transplant recipients and mechanisms of ultraviolet light-mediated immunomodulation. In this review, we integrate multiple lines of evidence highlighting the roles of the immune system in skin cancer. First, we discuss the concepts of cancer immunosurveillance and immunoediting as they might relate to human skin cancers. We then describe the clinical and molecular mechanisms of skin cancer development and progression in the contexts of therapeutic immunosuppression in organ transplant recipients, viral oncogenesis, and ultraviolet light-induced immunomodulation with a primary focus on basal cell carcinoma and squamous cell carcinoma. The clinical evidence supporting expanding roles for immunotherapy is also described. Finally, we discuss recent research examining the functions of particular immune cell subsets in skin cancer and how they might contribute to both anti-tumour and pro-tumour effects. A better understanding of the biological mechanisms of cancer immunosurveillance holds the promise of enabling better therapies.

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Section: Clinical Studies Linking Immunosuppression With Skin Cancermentioning

confidence: 99%

Roles of the immune system in skin cancer

Rangwala

Tsai

2011

British Journal of Dermatology

164

147

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“…In 2009, a total of 68,720 new cases of melanoma were reported in the United States alone, with about 8,650 people expected to die from this disease (1, 2). As yet, there are no effective treatments of metastatic melanoma.…”

Section: Introductionmentioning

confidence: 99%

β-Blockers and Survival among Danish Patients with Malignant Melanoma: A Population-Based Cohort Study

Lemeshow

Sørensen

Phillips

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

194

141

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Background To study whether use of β-blockers increases survival in patients with malignant melanoma because experimental data suggest that catecholamine hormones may be involved in stimulating the aggressiveness of malignant melanoma. Methods A total of 4,179 patients diagnosed with malignant melanoma in Denmark with a median follow-up of 4.9 years and identified in the Danish Cancer Registry participated. Data on β-blocker use, comorbidity, and survival were obtained from medical and administrative databases. Cox proportional hazards models were used to estimate HRs for all-cause mortality with 95% CIs with adjustment for prognostic factors. Results A total of 372 (8.9%) patients with malignant melanoma were treated with β-blockers within 90 days of melanoma diagnosis. The median β-blocker duration for exposure within 90 days of melanoma diagnosis, more than 90 days, and no prior exposure was 7.6, 1.4, and 0 years, respectively. The patients receiving β-blockers were older, had more comorbidities, and more cardiovascular and psychotropic drug user than the patients receiving no β-blockers prior to melanoma diagnosis. After adjustment for age and comorbidity index, the HR for melanoma death was 0.87 (95% CI: 0.64–1.20) and for all-cause mortality was 0.81 (95% CI: 0.67–0.97). Conclusion Increased survival time of patients with melanoma receiving β-blockers suggests that this class of drugs may hold promise in treatment strategy for these patients. Impact The observations described here suggest that catecholamines may retard melanoma progression and that β-blockers may have unrecognized potential as a therapeutic intervention for melanoma.

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“…In a human study, O'Dell et al (1980) sensitized volunteers to 2,4 dinitrochlorobenzene (DNCB). Higher concentrations of DNCB were needed to elicit positive patch test reactions on the sundamaged skin of the neck than on the protected skin of the upper back.…”

Section: Resultsmentioning

confidence: 99%

“…In either event, it has been shown that u.v. light exposure inhibits contact sensitivities in mice (Noonan, Pederson & Kripke, 1980), guinea-pigs (Morison & Parrish, 1980) and humans (O'Dell et al, 1980). It seems probable that the effect of the u.v.…”

mentioning

confidence: 99%

Ultraviolet light treatment delays contact sensitization to nitrogen mustard

et al. 1981

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Contact sensitivity to nitrogen mustard was delayed after first treating patients with u.v. light. While the number of patients becoming sensitive to nitrogen mustard after ultraviolet light exposure was not significantly different from the control, the number of patients who became sensitive in the first 30 days was significantly less than the control group. It is postulated than this delay in sensitization is due to an alteration of the patients' epidermal Langerhans cells, produced by the u.v. light exposure.

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Diminished immune response in sun-damaged skin

Cited by 23 publications

References 0 publications

Roles of the immune system in skin cancer

Roles of the immune system in skin cancer

β-Blockers and Survival among Danish Patients with Malignant Melanoma: A Population-Based Cohort Study

Ultraviolet light treatment delays contact sensitization to nitrogen mustard

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