Diminished circulating concentration of interleukin‐35 in <i>Helicobacter pylori</i>‐infected patients with peptic ulcer: Its association with <scp>FOXP</scp>3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

Bassagh, Arezoo; Abasi, Mehdi Hayatbakhsh; Larussa, Tiziana; Ghazizadeh, Motahareh; Nemati, Maryam; Mirkamandar, Ehsan; Jafarzadeh, Abdollah

doi:10.1111/hel.12501

Cited by 6 publications

(3 citation statements)

References 42 publications

(124 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems logical that IL-35 acts as a part of post-CPB anti-inflammatory phase and represents an attempt of the host to counteract the postoperative inflammatory responses, characterized by IL-1, IL-6, TNF [ 24 , 25 ] , and chemokines release, and of inflammatory cells, specially neutrophils activation [ 24 , 26 ] and the subsequent microcirculation and organ dysfunction [ 27 ] . Regarding this, we did not find any association between rs3761548, rs3761547 FoxP3 promoter polymorphisms and the IL-35 serum levels increase after CPB, but our findings about the association between IL-35 levels and preoperative (age, BMI) and intraoperative (CPB time and MAP) variables in carriers of the rs3761548 AA genotype are somehow consistent with Bassagh et al [ 28 ] study in peptic ulcer patients, Jafarzadeh et al [ 29 ] study in multiple sclerosis, and Chatrabnous et al [ 30 ] study in prostate cancer patients which showed that the IL-35 levels were significantly different in subjects with AA genotype.…”

Section: Discussionsupporting

confidence: 91%

The Relationship Between Serum Concentration of Interleukin-35 and FoxP3 Polymorphism in Patients Undergoing Coronary Artery Bypass Graft Surgery

Dasturian

Naderi

Farshidfar

et al. 2020

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Objective To investigate the association between interleukin-35 (IL-35) levels and single nucleotide polymorphisms (rs3761548, rs3761547) of the FoxP3 gene in coronary artery bypass grafting (CABG) patients. Methods We conducted a prospective study including 140 patients, who were scheduled for elective isolated on-pump CABG with cardiopulmonary bypass (CPB) from January 2017 to September 2018 in the Jorjani heart center. Blood samples were collected before and 12 hours after the operation. Serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the pattern of genetic variations was assessed using single specific primer-polymerase chain reaction. Results The serum concentrations of IL-35 after surgery were significantly higher than pre-surgery levels (18.4±8.3 vs . 9.89±3.2, respectively, P =0.002). There was no significant association between genotype frequencies of rs3761548 and rs3761547 and elevated IL-35 levels ( P >0.05). There were significant associations between IL-35 levels and preoperative variables, including age (r=-0.34, P =0.047) and body mass index (r=-0.41, P =0.045), and intraoperative variables, including CPB time (r=0.4, P =0.02) and mean arterial pressure (r=-0.38, P =0.046), in carriers of the rs3761548 AA genotype. Conclusion Serum IL-35 concentrations were significantly increased in CPB patients, which may contribute to the post-CPB compensatory anti-inflammatory response syndrome. IL-35 increased levels were not influenced by FoxP3 promoter polymorphisms (rs3761548, rs3761547).

show abstract

Section: Discussionsupporting

confidence: 91%

The Relationship Between Serum Concentration of Interleukin-35 and FoxP3 Polymorphism in Patients Undergoing Coronary Artery Bypass Graft Surgery

Dasturian

Naderi

Farshidfar

et al. 2020

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

show abstract

“…Consistently, diminished IL-35 is primarily associated with chronic infection [41] and type 1 diabetes mellitus [42]. Also, a low concentration of IL-35 was influenced in the progression of peptic ulcer of patients infected with H. pylori [43]. However, IL-35-mediated downregulation is effective to inhibit developed β-cell autoimmunity and encourage the use of IL-35 in T1DM treatment and other T-cell-mediated autoimmune diseases [44].…”

Section: Discussionmentioning

confidence: 93%

Effect of antidiabetic therapy on TNF-α, IL-18, IL-23 and IL-35 levels in T2DM patients with coincidental Helicobacter pylori infection

Abdel-Moneim

El‐Twab

Nabil

et al. 2020

Journal of Taibah University for Science

View full text Add to dashboard Cite

This study aimed to evaluate the relationship between tumour-necrosis factor-alpha (TNF-α), interleukin (IL)-18, IL-23, IL-35 and Heilcobacter (H) pylori infection with T2DM. A total of 25 healthy subjects and 102 confirmed T2DM patients were enrolled in this study. Diabetic patients were subdivided into six groups according to antidiabetic therapy. Diabetic non-treated patients exhibited a significant elevation in H. Pylori-Ig-G, TNF-α, IL-18, and IL-23 levels, but a noticeable decrease in IL-35 expression was observed compared to healthy controls. Antidiabetic therapy induced a significant decrease in the level of glycosylated hemoglobin (HbA1c), TNF-α, IL-18 and IL-23, while IL-35 expression was upregulated compared to diabetic controls. The results exhibited a positive correlation between H. pylori and HbA1c%, TNF-α, IL-18, and IL-23 values, and also between HbA1c% and TNF-α, IL-18 and IL-23 levels. Therefore, antidiabetic therapy decreases significantly the hyperglycemic state and circulating level of inflammatory cytokines which reflects their potential anti-inflammatory effects.

show abstract

“…Moreover, the following polymorphisms in various cytokines have been linked with an increased risk of PUD: TNF-a À1031 and À863 single nucleotide polymorphisms (SNPs) [11], low levels of interleukin-35 and interleukin-33,high levels of interleukin-37 with genetic variation at SNP rs3761548 (AA genotype and A allele) in the forkhead box p3 (FOXP3) gene, rs1929992 (GG genotype and G allele) in the intron 3 region of the IL-33 gene, and the rs3811047 and rs2723176 SNPs (genotype GG and allele G, genotypes CC and allele C, respectively) on chromosome 2q13 respectively with CagA-positive HP infection [12][13][14]. In these studies, certain limitations in the expression of a genetic region, determinations of regulatory T (Treg) cell frequency and the measurements of other cytokines were not investigated.…”

Section: Introductionmentioning

confidence: 99%

The role of toll-like receptors in peptic ulcer disease

Jin

Nepal

Gao

2021

Immunological Medicine

View full text Add to dashboard Cite

Helicobacter pylori (HP) is the primary etiologic factor that induces events in the immune system that lead to peptic ulcers. Toll-like receptors (TLRs) are an important part of the innate immune system, as they play pivotal roles in pathogen-associated molecular pattern (PAMP) recognition of HP as well host-associated damage-associated molecular patterns (DAMPs). Recent advancements such as COX-2 production, LPS recognition through TLR2, CagL, and CagY protein of HP activating TLR5, TLR9 activation via type IV secretion system (T4SS) using DNA transfer, TLR polymorphisms, their adaptor molecules, cytokines, and other factors play a significant role in PUD. Thus, some novel PUD treatments including Chuyou Yuyang granules, function by TLR4/NF-jB signaling pathway suppression and TNF-a and IL-18 inhibition also rely on TLR signaling. Similarly glycyrrhetinic acid (GA) treatment activates TLR-4 in Ana-1 cells not via TRIF, but via MYD88 expression, which is significantly upregulated to cure PUD. Therefore, understanding TLR signaling complexity and its resultant immune modulation after host-pathogen interactions is pivotal to drug and vaccine development for other diseases as well including cancer and recent pandemic COVID-19. In this review, we summarize the TLRs and HP interaction; its pathophysiology-related signaling pathways, polymorphisms, and pharmaceutical approaches toward PUD.

show abstract

Diminished circulating concentration of interleukin‐35 in Helicobacter pylori‐infected patients with peptic ulcer: Its association with FOXP3 gene polymorphism, bacterial virulence factor CagA, and gender of patients

Cited by 6 publications

References 42 publications

The Relationship Between Serum Concentration of Interleukin-35 and FoxP3 Polymorphism in Patients Undergoing Coronary Artery Bypass Graft Surgery

The Relationship Between Serum Concentration of Interleukin-35 and FoxP3 Polymorphism in Patients Undergoing Coronary Artery Bypass Graft Surgery

Effect of antidiabetic therapy on TNF-α, IL-18, IL-23 and IL-35 levels in T2DM patients with coincidental Helicobacter pylori infection

The role of toll-like receptors in peptic ulcer disease

Contact Info

Product

Resources

About