Dilated Fourth Ventricle in Fetuses with Trisomy 18, Trisomy 13 and Triploidy at 11–13 Weeks’ Gestation

Loureiro, T.; Ferreira, Ana Fatima A.; Ushakov, F.; Montenegro, Nuno; Nicolaides, Kypros H.

doi:10.1159/000338113

Cited by 22 publications

(22 citation statements)

References 35 publications

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“…It was found that, in the diandric type, fetal NT is increased as well as maternal serum total human chorionic gonadotropin (hCG), free β ‐hCG, and AFP with mildly decreased PAPP‐A, while the digynic type is characterized by a normal fetal NT with markedly decreased maternal serum total hCG, free β ‐hCG, and PAPP‐A . However, the sonographic characteristics described in these studies in the first trimester are sparse and non‐specific, such as severe asymmetrical fetal growth restriction . Another disadvantage of the FTS for triploidy is that FTS identifies mostly the diandric type that is less common.…”

Section: Discussionmentioning

confidence: 99%

Prenatal sonographic features of triploidy at 12–16 weeks

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Prenatal sonographic features of triploidy at 12–16 weeks

et al. 2016

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“…In future studies it could also be interesting to compare data from fetuses with increased CSF as observed in Trisomy 18, 13 or others [16] or in the group at high risk for a Dandy-Walker malformation [17] or Blake's pouch cyst.…”

Section: Discussionmentioning

confidence: 99%

Fluid Area Measurements in the Posterior Fossa at 11-13 Weeks in Normal Fetuses and Fetuses with Open Spina Bifida

Karl

Chaoui²

2015

Fetal Diagn Ther

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Objectives: To measure the area of the intracranial translucency (IT) (syn: 4th ventricle) and the future cisterna magna (CM) in normal fetuses and to compare with fetuses with open spina bifida. Patients: In the midsagittal plane of the face of 220 fetuses between 11 and 13 weeks' gestation, the areas of the IT and CM were measured and the sum, defined as the posterior fossa fluid (PFF) area was calculated. Reference ranges were constructed in relation to the crown-rump length. The study group consisted of 21 fetuses with open spina bifida and showed in all cases a single pocket of fluid in the posterior fossa. Fetuses with no fluid in the fossa were excluded. This PFF-area was measured and compared with the reference range of the IT-area and the PFF-area of normal fetuses and Z-scores were calculated. Results: In normal fetuses, a significant increase of the IT-, the CM- and the PFF-area was found as a sign of the expanding posterior fossa. The mean PFF-area increased from 8.55 to 29.72 mm² in the observation period. Fetuses with open spina bifida had reduced fluid in the posterior fossa with values ranging between 2.39 and 5.08 mm² and significantly lower Z-scores. Conclusions: Fetuses with open spina bifida have an abnormally small posterior fossa at 11-13 weeks' and in cases where the cerebrospinal fluid is still present, the fluid area in the midsagittal plane is reduced when compared to normal fetuses. Area fluid assessment can be an additional useful measurement in suspicious cases for open spina bifida in early gestation.

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“…Other studies had demonstrated that the posterior fossa BSOB diameter and the anteroposterior diameter of the fourth ventricle of the trisomy 18, trisomy 13, and triploid fetuses were significantly longer than the normal fetuses [11]. It was also reported that the BS diameter and BS/BSOB ratio were decreased in axial view of the trisomy 18 and trisomy 13 [21]. In consistent with the previous reports, our study confirmed that the BS and BS/BSOB ratio were significantly lower in trisomy 13, trisomy 18 and monosomy X in comparison with normal fetuses (fig.…”

Section: Discussionmentioning

confidence: 99%

The BS/BSOB Ratio in Aneuploidy Fetuses at 11-13 Weeks Gestation

et al. 2015

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Objective: The posterior fossa of normal fetuses was evaluated and compared with those having chromosomal abnormalities at 11-13+6 weeks' gestation in Chinese population. Methods: In 518 normal fetuses referred to first trimester screening, fetal brain stem (BS) and brain stem to occipital bone distance (BSOB) were measured prospectively. The BS and BSOB were also measured on stored images in fetuses with confirmed trisomy 21 (n = 38), Trisomy 18 (n = 26), Trisomy 13 (n = 8), and monosomy X (n = 8). Results: The BS diameter and BSOB distance correlated linearly with fetal crown-rump length (CRL) by regression analysis. The BS to BSOB ratio was below the 5th percentile in 2 (5.26%), 11 (44%), 4 (50%) and 4 (50%) fetuses with trisomy 21, trisomy 18, trisomy 13 and monosomy X, respectively. Thus, both BS and BS/BSOB ratio were significantly lower in trisomy 18, trisomy 13 and monosomy X fetuses when compared to the reference range but not in fetuses with Trisomy 21. Conclusion: In ultrasound scans performed at the 11-13⁺⁶ gestation weeks, fetuses with trisomy 18, 13, and monosomy X had lower BS/BSOB ratios. But trisomy 21 fetuses did not show significant differences in posterior fossa compared to the normal population.

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Dilated Fourth Ventricle in Fetuses with Trisomy 18, Trisomy 13 and Triploidy at 11–13 Weeks’ Gestation

Cited by 22 publications

References 35 publications

Prenatal sonographic features of triploidy at 12–16 weeks

Prenatal sonographic features of triploidy at 12–16 weeks

Fluid Area Measurements in the Posterior Fossa at 11-13 Weeks in Normal Fetuses and Fetuses with Open Spina Bifida

The BS/BSOB Ratio in Aneuploidy Fetuses at 11-13 Weeks Gestation

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