Diindolylmethane, 2. Mitt. 4‐Nitrophenyl‐substituiertes 2,2′‐Diindolylmethan

Abstract

Bei der chlorwasserstoff-katalysierten Kondensation von Tryptophanmethylester rnit arornatischen Aldehyden lassen sich durch praparative DC 2,2'-Diindolylmethane sowie 1,2,3,4-Tetrahydro-P-carboline isolierenl). Q Verlag Chemie. Gmhtl. Weinheim 1979

Bis- and Trisindolylmethanes (BIMs and TIMs)

“…He also investigated the stereoisomers of the prepared compounds 224 (Scheme 80). [451][452][453][454][455] In the presence of catalytic amounts of cyanuric chloride or trichloro-1,3,5-triazine (TCT) indole-3-acetic acid 225 reacts with 4-methoxybenzaldehyde to yield the corresponding BIM 226 (87%, Scheme 81). 456 Noland et al reported that indoles and acetone in acidic media yield the 2,2-BIM 227 (Figure 12).…”

“…Pindur prepared 2,2′-BIM 224 from tryptophan 223 and arylaldehydes. He also investigated the stereoisomers of the prepared compounds 224 (Scheme ). – …”