Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioral despair test; antidepressants facilitate nifedipine action

Mogilnicka, E; Czyrak, A; J, Maj

doi:10.1016/0014-2999(87)90480-8

Cited by 77 publications

(36 citation statements)

References 7 publications

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“…The present results are in line with previous reports (Mogilnicka et al, 1987) that nifedipine possess antidepressant actions in rodents. Results also demonstrate that furosemide has antidepressant-like effects in mice and that the combinations of furosemide + nifedipine, furosemide + imipramine and furosemide + sertraline enhanced the antidepressant-like effects of furosemide in the FST and TST models of depression in mice on days 15 and 31 significantly different from acute values (P < O.01).…”

Section: Discussionsupporting

confidence: 94%

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Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

S.¹,

E.²

2012

Afr. J. Biotechnol.

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Section: Discussionsupporting

confidence: 94%

“…The mice were injected intraperitoneally (i.p.). The doses of drugs were chosen from previous studies (Eraly et al, 2006;Luszczki et al, 2003;Cryan et al, 2004;Kosuda et al, 1997;Hesdorfffer et al, 2001;Mogilnicka et al, 1987).…”

Section: Methodsmentioning

confidence: 99%

Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

S.¹,

E.²

2012

Afr. J. Biotechnol.

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“…Thus, an absence of effect in rodents could arise from poor brain penetration which may be the case for a compound which would otherwise exert CNS effects. However, voltage-dependent calcium-channel antagonists, especially DHP compounds, have been demonstrated to produce antidepressant-like effects in mouse behavioral despair models and their actions were facilitated by antidepressants [Mogilnicka et al, 1987;Nowak et al, 1993;Cohen et al, 1997;Biala, 1998;Galeotti et al, 2006]. Similarly, it has been suggested that BayK 8644, an LTCC activator, causes a depressant-like effect in the same animal models [Sinnegger-Brauns et al, 2004].…”

Section: Mood and Anxiety Disordersmentioning

confidence: 94%

L‐type calcium channels and psychiatric disorders: A brief review

Casamassima

Hay

Benedetti

et al. 2010

American J of Med Genetics Pt B

116

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Emerging evidence from genome-wide association studies (GWAS) support the association of polymorphisms in the alpha 1C subunit of the L-type voltage-gated calcium channel gene (CACNA1C) with bipolar disorder. These studies extend a rich prior literature implicating dysfunction of L-type calcium channels (LTCCs) in the pathophysiology of neuropsychiatric disorders. Moreover, calcium channel blockers reduce Ca(2+) flux by binding to the α1 subunit of the LTCC and are used extensively for treating hypertension, preventing angina, cardiac arrhythmias and stroke. Calcium channel blockers have also been studied clinically in psychiatric conditions such as mood disorders and substance abuse/dependence, yielding conflicting results. In this review, we begin with a summary of LTCC pharmacology. For each category of disorder, this article then provides a review of animal and human data. In particular, we extensively focus on animal models of depression and clinical trials in mood disorders and substance abuse/dependence. Through examining rationale and study design of published clinical trials, we provide some of the possible reasons why we still do not have definitive evidence of efficacy of calcium-channel antagonists for mood disorders. Refinement of genetic results and target phenotypes, enrollment of adequate sample sizes in clinical trials and progress in physiologic and pharmacologic studies to synthesize tissue and isoform specific calcium channel antagonists, are all future challenges of research in this promising field. © 2010 Wiley-Liss, Inc.

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“…Nifedipine reduces immobility in the behavioral despair test, which is felt to be an animal model of antidepressant activity [33]. Verapamil has pre vented antidepressant-induced hypomania in several pa tients [29,[34][35][36] and flunarizine was thought to reduce depressive recurrences in one patient [37], Verapamil may have acute antidepressant properties in some bipolar [1, 38; J. Berlant, unpubl.…”

mentioning

confidence: 99%

Calcium Antagonists in Manic-Depressive Illness

Dubovsky

1993

Neuropsychobiology

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Increased free intracellular calcium ion concentration ([Ca²⁺]_¡) has been found in lymphocytes and blood platelets of patients with bipolar affective disorders when they are acutely ill, but not after recovery. Because lithium alters intracellular calcium ion dynamics and lowers platelet [Ca²⁺]_¡ in affectively ill patients but not controls, drugs whose primary action is to modulate [Ca²⁺]_¡ in hyperactive cells have been used as antimanic agents. The best studied of these is verapamil, a calcium channel blocking agent (CCB) that appears most effective for lithium-responsive patients. Because they interact with different central CCB receptors, second-generation CCBs may have a different spectrum of action. CCBs are usually well tolerated and may be useful for a number of other psychiatric, neurological and medical conditions.

show abstract

Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioral despair test; antidepressants facilitate nifedipine action

Cited by 77 publications

References 7 publications

Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

Effect of nifedipine, imipramine and sertraline on the antidepressant-like actions of furosemide in forced swim (FST) and tail suspension (TST) tests models of depression in mice

L‐type calcium channels and psychiatric disorders: A brief review

Calcium Antagonists in Manic-Depressive Illness

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