Diffusion Tensor Imaging Shows Different Topographic Involvement of the Thalamus in Progressive Supranuclear Palsy and Corticobasal Degeneration

Erbetta, Alessandra; Mandelli, ML; Savoiardo, M.; Grisoli, Marina; Bizzi, Alberto; Soliveri, Paola; Chiapparini, Luisa; Prioni, Sara; Bruzzone, Maria Grazia; Girotti, F.

doi:10.3174/ajnr.a1615

Cited by 98 publications

(76 citation statements)

References 43 publications

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“…Three studies 17,28,40 compared participants with corticobasal syndrome and controls (table e-1). A VBA study 40 showed primarily cortical reduction of FA.…”

Section: Resultsmentioning

confidence: 99%

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Diffusion tensor imaging in parkinsonian syndromes

2013

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Objectives: We performed a systematic review to assess alterations in measures of diffusion tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in diagnosis and as a candidate biomarker. Methods:We searched EMBASE and Medline databases for DTI studies comparing parkinsonian syndromes or related dementias with controls or another defined parkinsonian syndrome. Key details for each study regarding participants, imaging methods, and results were extracted. Estimates were pooled, where appropriate, by random-effects meta-analysis. Results:Of 333 results, we identified 43 studies suitable for inclusion (958 patients, 764 controls). DTI measures detected alterations in all parkinsonian syndromes, with distribution varying differentially with disease type. Nine studies were included in a meta-analysis of the substantia nigra in Parkinson disease. A notable effect size was found for lowered fractional anisotropy in the substantia nigra for patients with Parkinson disease vs controls (20.639, 95% confidence interval 20.860 to 20.417, p , 0.0001).Conclusion: DTI may be a promising biomarker in parkinsonian syndromes and have a future role in differential diagnosis. Larger cohort studies are required to investigate some encouraging preliminary findings. Given the complexity of the parkinsonian syndromes, it is likely that any potential DTI biomarker would be used in combination with other relevant biomarkers. Differences in natural history and therapy options make early and accurate diagnosis of parkinsonian syndromes important. 1 Emission tomography (SPECT or PET) has a role but it can be expensive, with limited availability, and requires radioactive tracers. 2 There is particular interest in the potential of advanced structural MRI techniques to differentiate among parkinsonian syndromes and to offer candidate biomarkers, facilitating early or premanifest diagnosis and monitoring of disease progression.Diffusion tensor imaging (DTI) is an MRI technique assessing the orientation and integrity of white matter tracts in vivo by measuring the diffusion of water molecules in neural fibers 3 and it also shows promise for studying gray matter areas. It estimates both the degree of directionality using anisotropy (frequently fractional anisotropy [FA]) and the overall movement of molecules (mean diffusivity [MD]; trace; apparent diffusion coefficient [ADC]). These measurements can either be extracted locally in predefined regions using region of interest (ROI) analysis or tractography or, alternatively, globally using voxel-based analysis (VBA) or tract-based spatial statistics (TBSS). Disruptions to microstructural tissue integrity, such as those found in the neurodegeneration of parkinsonian syndromes can be associated with alterations in anisotropy and diffusivity measures. 3 We therefore performed a systematic review of the literature to assess

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“…Three studies 17,28,40 compared participants with corticobasal syndrome and controls (table e-1). A VBA study 40 showed primarily cortical reduction of FA.…”

Section: Resultsmentioning

confidence: 99%

“…Progressive supranuclear palsy. Frontal white matter FA was investigated in 2 ROI studies 6,28 ; both detected reductions in patients vs controls (table e-1). One VBA study 30 also detected significant frontal FA reductions but another TBSS study 29 did not.…”

Section: Resultsmentioning

confidence: 99%

Diffusion tensor imaging in parkinsonian syndromes

2013

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“…5 The presence of AOS is associated with corticobasal degeneration pathology 5 and previous studies of corticobasal syndrome have similarly reported diffusivity changes in the supplemental motor area and frontoparietal fibers, which likely coincide with the superior SLF. 38,39 Detailed speech and language assessments were not available for the subjects in this study, however, and therefore the contribution of these motor problems is presently unclear.…”

Section: Gray Matter Voxel-level Analysesmentioning

confidence: 99%

Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia

Whitwell¹,

Avula²,

Senjem³

et al. 2010

Neurology

228

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Objective: To use diffusion tensor imaging (DTI) to assess gray matter and white matter tract diffusion in behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SMD), and progressive nonfluent aphasia (PNFA). Methods:This was a case-control study where 16 subjects with bvFTD, 7 with PNFA, and 4 with SMD were identified and matched by age and gender to 19 controls. All subjects had 3-T head MRI with a DTI sequence with diffusion encoding in 21 directions. Gray matter mean diffusivity (MD) was assessed using a region-of-interest (ROI) and voxel-level approach, and voxel-based morphometry was used to assess patterns of gray matter loss. White matter tract diffusivity (fractional anisotropy and radial diffusivity) was assessed by placing ROIs on tracts of interest. Results:In bvFTD, increased gray matter MD and gray matter loss were identified bilaterally throughout frontal and temporal lobes, with abnormal diffusivity observed in white matter tracts that connect to these regions. In SMD, gray matter loss and increased MD were identified predominantly in the left temporal lobe, with tract abnormalities observed in the inferior longitudinal fasciculus and uncinate fasciculus. In PNFA, gray matter loss and increased MD were observed in left inferior frontal lobe, insula, and supplemental motor area, with tract abnormalities observed in the superior longitudinal fasciculus. Conclusions:The diffusivity of gray matter is increased in regions that are atrophic in frontotemporal dementia, suggesting disruption of the cytoarchitecture of remaining tissue. Furthermore, damage was identified in white matter tracts that interconnect these regions, supporting the hypothesis that these diseases involve different and specific brain networks. Neurology ® 2010;74:1279 -1287 GLOSSARY AAL ϭ automated anatomic labeling; AC ϭ anterior cingulate; ADRC ϭ Alzheimer's Disease Research Center; ADPR ϭ Alzheimer's Disease Patient Registry; AOS ϭ apraxia of speech; bvFTD ϭ behavioral variant frontotemporal dementia; CV ϭ coefficient of variation; DA ϭ axial diffusivity; DR ϭ radial diffusivity; DTI ϭ diffusion tensor imaging; FA ϭ fractional anisotropy; FDR ϭ false discovery rate; FOV ϭ field of view; FTD ϭ frontotemporal dementia; FWHM ϭ full-width at half-maximum; GCC ϭ genu of the corpus callosum; HDW ϭ high-dimensional warping; ILF ϭ inferior longitudinal fasciculus; MD ϭ mean diffusivity; MPRAGE ϭ magnetization prepared rapid acquisition gradient echo; PC ϭ posterior cingulate; PNFA ϭ progressive nonfluent aphasia; PVC ϭ partial volume correction; ROI ϭ region of interest; SLF ϭ superior longitudinal fasciculus; SMD ϭ semantic dementia; UNC ϭ uncinate fasciculus.Diffusion tensor imaging (DTI) has recently emerged as a valuable technique for assessing structural changes in the brain.1-3 It can provide information on microstructural tissue integrity by measuring changes in water diffusion through tissue. This is particularly useful for assessing the integrity of white matter tracts because DTI can provide a measure ...

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“…Previous studies of PD and atypical parkinsonisms demonstrated thalamic abnormalities by using region-of-interest or voxelwise approaches. [9][10][11][12][13] MR imaging-based analysis of the shape of the subcortical structures provides useful pieces of information about the location and pattern of structural abnormalities associated with these pathologic conditions. Using such an approach, several studies reported regional thalamic damage in patients with schizophrenia, obsessive-compulsive disorders, Alzheimer disease, and Tourette syndrome.…”

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confidence: 99%