Diffusion-Tensor Imaging of Human Articular Cartilage Specimens with Early Signs of Cartilage Damage

Raya, José G.; Melkus, Gerd; Adam-Neumair, Silvia; Dietrich, Olaf; Mützel, Elisabeth; Reiser, Maximilian; Putz, Reinhard; Kirsch, Thorsten; Jakob, Peter M.; Gläser, Christian

doi:10.1148/radiol.12120954

Cited by 75 publications

(75 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Raya et al (26) investigated the value of DTI to detect early cartilage degeneration ex vivo in samples with early cartilage damage (Fig. 7).…”

Section: Diffusion Tensor Imaging: Diagnosis Of Early Cartilage Damagementioning

confidence: 99%

“…The key idea behind the use of DTI is that the various components of the cartilage matrix have different effects on the motion of water molecules (20). The collagen network favors the motion of water along the collagen fibers inducing anisotropy in the motion of water, which can be measured with fractional anisotropy (FA) (20)(21)(22)(23)(24)(25)(26)(27). PG molecules, on the other hand, do not show a preferred orientation and therefore restrict the motion of water molecules equally in all directions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Techniques and applications of in vivo diffusion imaging of articular cartilage

Raya

2015

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

Early in the process of osteoarthritis (OA) the composition (water, proteoglycan [PG], and collagen) and structure of articular cartilage is altered leading to changes in its mechanical properties. A technique that can assess the composition and structure of the cartilage in vivo can provide insight in the mechanical integrity of articular cartilage and become a powerful tool for the early diagnosis of OA. Diffusion tensor imaging (DTI) has been proposed as a biomarker for cartilage composition and structure. DTI is sensitive to the PG content through the mean diffusivity (MD) and to the collagen architecture through the fractional anisotropy (FA). However, the acquisition of DTI of articular cartilage in vivo is challenging due to the short T2 of articular cartilage (~40 ms at 3 T) and the high resolution needed (0.5-0.7 mm in plane) to depict the cartilage anatomy. We describe the pulse sequences used for in vivo DTI of articular cartilage and discus general strategies for protocol optimization. We provide a comprehensive review of measurements of DTI of articular cartilage from ex vivo validation experiments to its recent clinical applications.

show abstract

“…Raya et al (26) investigated the value of DTI to detect early cartilage degeneration ex vivo in samples with early cartilage damage (Fig. 7).…”

Section: Diffusion Tensor Imaging: Diagnosis Of Early Cartilage Damagementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Techniques and applications of in vivo diffusion imaging of articular cartilage

Raya

2015

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

show abstract

“…195 Fractional anisotropy has been found to correlate strongly with the orientation of the collagen fiber network assessed using polarized light microscopy and electron scanning microscopy. 194,197,198 Apparent diffusion coefficient and fractional anisotropy have also been shown to be highly sensitive for detecting early cartilage degeneration in both ex vivo 199 and in vivo 200 studies. Diffusor tensor imaging has the unique advantage of simultaneously assessing the proteoglycan and collagen components of articular cartilage in a single scan.…”

Section: Diffusion Imagingmentioning

confidence: 99%

Quantitative Magnetic Resonance Imaging of the Articular Cartilage of the Knee Joint

Kijowski

Chaudhary

2014

Magnetic Resonance Imaging Clinics of North America

View full text Add to dashboard Cite

“…Multiple techniques including gadolinium enhanced spin-lattice relaxation time (T 1 ) imaging [8, 9], sodium imaging [10, 11], spin-lattice relaxation time in the rotating frame (T 1rho ) imaging [12, 13], and chemical exchange-dependent saturation transfer (CEST) imaging [14, 15] have been shown to be sensitive for detecting changes in the proteoglycan content of cartilage. However, only a few MR techniques including spin-spin relaxation time (T 2 ) imaging [16–18] and diffusion tensor imaging [19–22] have been used to identify alterations in cartilage ultra-structure, and all currently used methods have limitations. T2 relaxation time is a nonspecific parameter which is influenced by multiple factors including organization of the collagen fiber network [16–18], water and macromolecular content [23–26], and orientation of cartilage relative to the main magnetic field [27].…”

Section: Introductionmentioning

confidence: 99%

Cross-relaxation imaging of human patellar cartilage in vivo at 3.0T

Sritanyaratana

Samsonov

Mossahebi

et al. 2014

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Objective To compare quantitative magnetization transfer (qMT) parameters of patellar cartilage measured using cross relaxation imaging (CRI) in asymptomatic volunteers and patients with osteoarthritis. Design The study was performed with Institutional Review Board approval and with all subjects signing informed consent. CRI of the knee joint was performed at 3.0T on 20 asymptomatic volunteers and 11 patients with osteoarthritis. The fraction of macromolecular bound protons (f), the exchange rate constant between macromolecular bound protons and free water protons (k), and the T2 relaxation time of macromolecular bound protons (T2B) of patellar cartilage were measured. Mann-Whitney-Wilcoxon rank-sum tests were used to compare qMT parameters between asymptomatic volunteers and patients with osteoarthritis. Results Average f, k, and T2B of patellar cartilage was 12.46%, 7.22 s−1, and 6.49 μs respectively for asymptomatic volunteers and 12.80%, 6.13 s−1, and 6.80 μs respectively for patients with osteoarthritis. There were statistically significant differences between groups of subjects for k (p<0.01) and T2B (p<0.0001) but not f (p=0.38) of patellar cartilage. Conclusion Patients with osteoarthritis had significantly lower k and significantly higher T2B of patellar cartilage than asymptomatic volunteers which suggests that qMT parameters can detect changes in the macromolecular matrix of degenerative cartilage. Key Words: Cartilage; MRI; Osteoarthritis; Magnetization Transfer

show abstract

Diffusion-Tensor Imaging of Human Articular Cartilage Specimens with Early Signs of Cartilage Damage

Abstract: DT imaging of articular cartilage can enable physicians to detect and grade early cartilage damage.

Cited by 75 publications

References 41 publications

Techniques and applications of in vivo diffusion imaging of articular cartilage

Techniques and applications of in vivo diffusion imaging of articular cartilage

Quantitative Magnetic Resonance Imaging of the Articular Cartilage of the Knee Joint

Cross-relaxation imaging of human patellar cartilage in vivo at 3.0T

Contact Info

Product

Resources

About