Diffuse intrapulmonary hemorrhage, renal failure and a systemic vasculitis

Thomashow, Byron; Felton, Charles P.; Navarro, Carlos

doi:10.1016/0002-9343(80)90371-x

Cited by 30 publications

(3 citation statements)

References 15 publications

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“…Undoubtedly, our patient had PBC, but the cause of the renal and hemorrhagic pulmonary syndrome led to several hypotheses. Although the final diagnosis should include Goodpasture's syndrome, other possibilities, including systemic vasculitis, idiopathic pulmonary hemosiderosis and systemic lupus erythematosus, were considered (14)(15)(16). The coexistence of PBC and glomerulonephritis has been reported five times so far (171, but the association of PBC with lung hemorrhage has to our knowledge never been reported, except in one case during the course of a D-peniCillamine treatment (4).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis

Bissuel¹,

Bizollon²,

Dijoud

et al. 1992

Hepatology

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We observed life-threatening intrapulmonary hemorrhages and focal proliferative glomerulonephritis in a 41-yr-old woman with primary biliary cirrhosis. The severity of the symptoms necessitated blood transfusions and mechanical ventilation; the patient improved with the help of corticosteroid therapy. No formal evidence of either Goodpasture's syndrome or any other well-defined systemic vasculitis could be found. Neutrophil cytoplasmic antibodies were initially positive and became undetectable after 3 mo of immunosuppressive treatment without relapse. This association has not been described previously and may be added to the list of extrahepatic immune-mediated conditions associated with primary biliary cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Pulmonary hemorrhage and glomerulonephritis in primary biliary cirrhosis

Bissuel¹,

Bizollon²,

Dijoud

et al. 1992

Hepatology

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“…17 25 87 106-109 116 117 Up to 25% of patients will die during the first episode of diffuse alveolar haemorrhage. In those who survive the response to treatment is good but recurrent episodes are to be expected, as with other types of vasculitis.…”

Section: Selected Small Vessel Vasculitides Of the Lungmentioning

confidence: 99%

Rare diseases bullet 10: Small vessel vasculitis of the lung

Schwarz

Brown²

2000

Thorax

133

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“…The same combination may also coexist in other disease pro cesses, including Wegener's granulomatosis [2], systemic lupus erythematosus [3], systemic vasculitis [4], cryoglo bulinemia [5], immune complex-mediated glomerulone phritis [6] and idiopathic crescentic glomerulonephritis with negative immunofluorescence [7]. This report doc uments the previously unreported occurrence of massive intrapulmonary hemorrhage and renal failure in an adult post-streptococcal Henoch-Schonlein purpura who was successfully treated with oral prednisolone.…”

Section: Introductionmentioning

confidence: 59%