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“…We extended our findings and confirmed the CR phenomenon in two other experimental human solid tumor models, Calu6 (lung anaplastic carcinoma) 11 and KB (nasopharyngeal carcinoma) 12 , 13 . As occurred with the PC model, Calu-6 and KB tumors clearly showed a significant reduction in the growth of the secondary implants that was proportional to the primary tumor volume at the time of the secondary tumor implant (Supplementary Fig.…”
Section: Resultssupporting
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“…We extended our findings and confirmed the CR phenomenon in two other experimental human solid tumor models, Calu6 (lung anaplastic carcinoma) 11 and KB (nasopharyngeal carcinoma) 12 , 13 . As occurred with the PC model, Calu-6 and KB tumors clearly showed a significant reduction in the growth of the secondary implants that was proportional to the primary tumor volume at the time of the secondary tumor implant (Supplementary Fig.…”
Section: Resultssupporting
“…The KB cell line was initiated in 1954 by biopsy of a human oral epidermoid carcinoma (Eagle, 1955) . It was shown to produce tumors, in common with other cell lines of neoplastic origin, upon injection into the cheek pouch of Syrian hamsters (Foley and Handler, 1957) . The KB cells used in our experiments were obtained from St .…”
Section: Methodsmentioning
“…I t is possible that the cheek pouch to which most investigators have transplanted heterologous malignant tissues may be an immunologically privileged environment, where the grafts either fail to elicit a maximal response or are to some extent exempt from its consequences. Some support for this view, which is a t present being investigated, may be derived from Foley and Handler's (1957) recent demonstration that cells from normal heterologous tissues will grow and proliferate for at least a short period in the cheek pouch, even without cortisone administration.…”
Section: Infeuence Of Cortisone On Skin Graft Survivalmentioning
“…Unlike all other common laboratory mammals, Syrian hamsters (Mesocricetus aurafus) appear to be unique in that they will often accept homografts of malignant tissues and, on occasion, even heterografts of both normal and malignant tissues (Toolan, 1955;Foley and Handler, 1957;Pierre, Verney, and Dixon, 1957). A detailed study has therefore been undertaken to determine whether the Syrian hamster's response to skin homografts also differs from that of other animals.…”
Section: Introductionmentioning