Differentiation of human urine-derived stem cells into interstitial cells of Cajal-like cells by exogenous gene modification: A preliminary study

Sun, Bishao; Dong, Xingyou; Zhao, Jiang; Yang, Zhenxing; Zhang, Yuanyuan; Li, Longkun

doi:10.1016/j.bbrc.2019.09.121

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…They also noted that USCs may possess indirect neurogenic and neuron rescue properties[ 35 ]. These results are in agreement with Sun et al[ 82 ] who demonstrated that gene modification of USCs could induce a large-scale capacity of differentiation into several lineage cells for tissue repair.…”

Section: Uscs: Applicationssupporting

confidence: 93%

Urine-derived stem/progenitor cells: A focus on their characterization and potential

Burdeyron

Giraud

Hauet

et al. 2020

WJSC

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Cell therapy, i.e ., the use of cells to repair an affected tissue or organ, is at the forefront of regenerative and personalized medicine. Among the multiple cell types that have been used for this purpose [including adult stem cells such as mesenchymal stem cells or pluripotent stem cells], urine-derived stem cells (USCs) have aroused interest in the past years. USCs display classical features of mesenchymal stem cells such as differentiation capacity and immunomodulation. Importantly, they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure, which is broadly applicable, whereas most adult stem cell types require invasive procedure. Moreover, USCs can be differentiated into renal cell types. This is of high interest for renal cell therapy-based regenerative approaches. This review will firstly describe the isolation and characterization of USCs. We will specifically present USC phenotype, which is not an object of consensus in the literature, as well as detail their differentiation capacity. In the second part of this review, we will present and discuss the main applications of USCs. These include use as a substrate to generate human induced pluripotent stem cells, but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or system. Importantly, we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes, which is a strategy being increasingly employed. In the last section, we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine.

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Section: Uscs: Applicationssupporting

confidence: 93%

Urine-derived stem/progenitor cells: A focus on their characterization and potential

Burdeyron

Giraud

Hauet

et al. 2020

WJSC

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“…CYP treatment for eight days resulted in a more significant up-regulation of Piezo1 in chronic bladder inflammation. ICC-LCs plays a vital role in regulating bladder activity, The abnormal number and function of bladder ICC-LCs are related to bladder inflammation ( 106 – 108 ). In terms of mechanism, Piezo1 and NCX reversely cooperate to trigger an increase in the continuous influx of Ca 2+ into the bladder ICC-LCs.…”

Section: Piezo1 Channel-mediated Chronic Inflammationmentioning

confidence: 99%

Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation

Liu

Zheng

et al. 2022

Front. Immunol.

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Mechanical damage is one of the predisposing factors of inflammation, and it runs through the entire inflammatory pathological process. Repeated or persistent damaging mechanical irritation leads to chronic inflammatory diseases. The mechanism of how mechanical forces induce inflammation is not fully understood. Piezo1 is a newly discovered mechanically sensitive ion channel. The Piezo1 channel opens in response to mechanical stimuli, transducing mechanical signals into an inflammatory cascade in the cell leading to tissue inflammation. A large amount of evidence shows that Piezo1 plays a vital role in the occurrence and progression of chronic inflammatory diseases. This mini-review briefly presents new evidence that Piezo1 responds to different mechanical stresses to trigger inflammation in various tissues. The discovery of Piezo1 provides new insights for the treatment of chronic inflammatory diseases related to mechanical stress. Inhibiting the transduction of damaging mechanical signals into inflammatory signals can inhibit inflammation and improve the outcome of inflammation at an early stage. The pharmacology of Piezo1 has shown bright prospects. The development of tissue-specific Piezo1 drugs for clinical use may be a new target for treating chronic inflammation.

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“…Thus, the overexpression of HCN4 produced a preliminary ICC-LC-like phenotype in USCs. Additional studies could reveal the function of successful USC differentiation in the treatment of UAB ( Sun et al, 2020 ).…”

Section: Applications Of Uscsmentioning

confidence: 99%

A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

et al. 2022

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Stem cells possess regenerative powers and multidirectional differentiation potential and play an important role in disease treatment and basic medical research. Urine-derived stem cells (USCs) represent a newly discovered type of stem cell with biological characteristics similar to those of mesenchymal stromal cells (MSCs), including their doubling time and immunophenotype. USCs are noninvasive and can be readily obtained from voided urine and steadily cultured. Based on advances in this field, USCs and their secretions have increasingly emerged as ideal sources. USCs may play regulatory roles in the cellular immune system, oxidative stress, revascularization, apoptosis and autophagy. This review summarizes the applications of USCs in tissue regeneration and various disease treatments. Furthermore, by analysing their limitations, we anticipate the development of more feasible therapeutic strategies to promote USC-based individualized treatment.

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Differentiation of human urine-derived stem cells into interstitial cells of Cajal-like cells by exogenous gene modification: A preliminary study

Cited by 9 publications

References 34 publications

Urine-derived stem/progenitor cells: A focus on their characterization and potential

Urine-derived stem/progenitor cells: A focus on their characterization and potential

Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation

A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

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