1970
DOI: 10.1136/jcp.23.6.464
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Differentiating neoplasms of hair germ

Abstract: This report describes a small group of unusual cutaneous neoplasms, probably derived from hair germ, which (1) recapitulate the development of the hair follicle; (2) illustrate an inductive relationship between epithelial and mesenchymal components analogous to that between hair bulb and dermal papilla; (3) demonstrate a topographical organization similar to that seen in the skin; and (4) do not correspond to neoplasms previously described. MaterialTwo of the three neoplasms (cases 1 and 2) were obtained from … Show more

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Cited by 72 publications
(38 citation statements)
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References 10 publications
(10 reference statements)
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“… 10,11 These tumours showed an inductive relationship between epithelial and mesenchymal components analogous to hair bulb and dermal papilla, with a topographical organization similar to that seen in the skin. Depending on the combination of epithelial and mesenchymal components and the amount of ‘stromal induction’, he classified these neoplasms into two groups: epithelial and mesenchymal 10–12 . However, most benign trichogenic tumours consist of varying portions of both components, often with the mesenchymal component being quite scant.…”
Section: Discussionmentioning
confidence: 87%
“… 10,11 These tumours showed an inductive relationship between epithelial and mesenchymal components analogous to hair bulb and dermal papilla, with a topographical organization similar to that seen in the skin. Depending on the combination of epithelial and mesenchymal components and the amount of ‘stromal induction’, he classified these neoplasms into two groups: epithelial and mesenchymal 10–12 . However, most benign trichogenic tumours consist of varying portions of both components, often with the mesenchymal component being quite scant.…”
Section: Discussionmentioning
confidence: 87%
“…During recent decades it has been shown that most tumors previously diagnosed as BCC were actually a benign neoplasm with follicular germinative differentiation referred to as trichoblastoma . The term trichoblastoma was first introduced by Headington in 1970 to describe a group of hair germ neoplasms with epithelial–mesenchymal differentiation, simulating various degrees of hair bulb differentiation . In 1988, Alessi et al .…”
Section: Discussionmentioning
confidence: 99%
“…[12][13][14] Characteristically, trichogenic tumors show an inductive relationship between epithelial and mesenchymal components. [12][13][14] Characteristically, trichogenic tumors show an inductive relationship between epithelial and mesenchymal components.…”
Section: Discussionmentioning
confidence: 99%
“…[12][13][14] The clinical presentation of trichogenic tumors includes superficial plaques, papules, and nodules. [12][13][14] The clinical presentation of trichogenic tumors includes superficial plaques, papules, and nodules.…”
mentioning
confidence: 99%