2022
DOI: 10.1371/journal.pgen.1010298
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: During meiosis, DNA double-strand breaks (DSBs) occur throughout the genome, a subset of which are repaired to form reciprocal crossovers between chromosomes. Crossovers are essential to ensure balanced chromosome segregation and to create new combinations of genetic variation. Meiotic DSBs are formed by a topoisomerase-VI-like complex, containing catalytic (e.g. SPO11) proteins and auxiliary (e.g. PRD3) proteins. Meiotic DSBs are formed in chromatin loops tethered to a linear chromosome axis, but the interrel… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
16
0

Year Published

2022
2022
2023
2023

Publication Types

Select...
3
2

Relationship

0
5

Authors

Journals

citations
Cited by 9 publications
(18 citation statements)
references
References 85 publications
(199 reference statements)
2
16
0
Order By: Relevance
“…1A). In line with a recent report, these findings revealed that in Arabidopsis, SPO11 increasingly accumulates until pachytene, when DSB number is significantly decreased and homologs have synapsed (Lambing et al, 2022).…”
Section: Extreme High Temperature Reduces Chromosome-localization Of ...supporting
confidence: 92%
See 4 more Smart Citations
“…1A). In line with a recent report, these findings revealed that in Arabidopsis, SPO11 increasingly accumulates until pachytene, when DSB number is significantly decreased and homologs have synapsed (Lambing et al, 2022).…”
Section: Extreme High Temperature Reduces Chromosome-localization Of ...supporting
confidence: 92%
“…In Arabidopsis, the chromosome axis plays multiple roles during HR, including roles in DSB formation, homolog synapsis and CO formation (Lambing et al, 2022; Lambing et al, 2020). To explore the potential role of the chromosome axis in ATM-mediated DSB repair at high temperature, we performed chromosome spread analysis and counted the chromosome fragments in metaphase I and anaphase I meiocytes in the single syn1 and double syn1 atm mutants at 20 and 37°C (Fig.…”
Section: Resultsmentioning
confidence: 99%
See 3 more Smart Citations