2005
DOI: 10.1007/s00280-005-0038-z View full text |Buy / Rent full text
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Abstract: Differential sensitivity was observed in human ESCC cell lines in response to paclitaxel treatment. G2/M arrest occurs with a prior to paclitaxel-induced apoptosis and might be mediated by the mitochondrial (intrinsic) apoptosis pathway in human ESCC cells.

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“…Although, there were different sensitivity effects of paclitaxel on esophageal squamous cell carcinoma cells versus esophageal adenocarcinoma cells, the tendency of paclitaxel to exhibit antiproliferative effects against esophageal cancer appeared to be consistent. In this study, cell cycle analysis revealed that paclitaxel induced the highest G 2 /M growth arrest in SKGT4 cells after exposure to 50 nM of the paclitaxel at 12 h. These observations are in agreement with earlier studies demonstrating paclitaxel induced G 2 /M phase cell cycle arrest in human breast, lung, gastric, and esophageal squamous carcinoma cells (16,17,24,25). Our results suggest that paclitaxel may induce cells to undergo apoptosis as result of the failure of the cell cycle checkpoint function by accumulation of cells in the G 2 /M phase in human esophageal adenocarcinoma cells.…”
Section: Discussionsupporting
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“…Although, there were different sensitivity effects of paclitaxel on esophageal squamous cell carcinoma cells versus esophageal adenocarcinoma cells, the tendency of paclitaxel to exhibit antiproliferative effects against esophageal cancer appeared to be consistent. In this study, cell cycle analysis revealed that paclitaxel induced the highest G 2 /M growth arrest in SKGT4 cells after exposure to 50 nM of the paclitaxel at 12 h. These observations are in agreement with earlier studies demonstrating paclitaxel induced G 2 /M phase cell cycle arrest in human breast, lung, gastric, and esophageal squamous carcinoma cells (16,17,24,25). Our results suggest that paclitaxel may induce cells to undergo apoptosis as result of the failure of the cell cycle checkpoint function by accumulation of cells in the G 2 /M phase in human esophageal adenocarcinoma cells.…”
Section: Discussionsupporting
“…Paclitaxel induced a time-and dose-dependent inhibition of cellular proliferation of SKGT4 cells. Previously published reports demonstrated similar effects of paclitaxel observed in human esophageal squamous cell carcinoma cells (16). Although, there were different sensitivity effects of paclitaxel on esophageal squamous cell carcinoma cells versus esophageal adenocarcinoma cells, the tendency of paclitaxel to exhibit antiproliferative effects against esophageal cancer appeared to be consistent.…”
Section: Discussionsupporting
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“…Our results indicate that paclitaxel is very efficient in the treatment of ovarian carcinoma cells inducing apoptosis. Paclitaxel is also a highly effective chemotherapeutic agent against adenocarcinomas and squamous cell carcinomas of the esophagus where it was also shown to induce apoptosis (30).…”
Section: Discussionmentioning