Differential Responding for Brain Stimulation Reward and Sucrose in High–Alcohol‐Drinking (HAD) and Low–Alcohol‐Drinking (LAD) Rats

Woods, Jennifer; McKay, Peter F.; Masters, Jacob; Seyoum, Regat; Chen, Shen-Hsing Annabel; Duff, Lorie La; Lewis, Michael J.; June, Harry L.

doi:10.1111/j.1530-0277.2003.tb04417.x

Cited by 7 publications

(17 citation statements)

References 47 publications

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“…Previous studies have demonstrated a positive association between home cage ethanol (EtOH) consumption and preference for sweet solutions in rodents (Badia-Elder et al, 2000;Kampov-Polevoy et al, 1995Overstreet et al, 1997;Stewart et al, 1998). More recently, Woods et al (2003) have extended these findings by demonstrating that across a number of reinforcement schedules, the high-alcoholdrinking (HAD) rats continue to display this positive association with the reinforcing effects of sweet, palatable solutions. Similar to rodents, human alcoholics have also been reported to display a propensity to consume sweet, palatable solutions , 1999.…”

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confidence: 86%

“…The computer then recorded responses made by the animal in the operant chamber and triggered an A13-65 isolated physiological stimulator (Coulbourn Instruments), which, depending on the schedule of reinforcement, delivered an electrical pulse of a given current intensity into the commu-tator through the electrode wire into the MFB. The electrical stimulation for the current study was set at 0.2-sec train of 100-Hz biphasic rectangular pulses of 1.0 msec in duration, similar to that of previous research (Lewis and June, 1990;Woods et al, 2003). Responses and reinforcements were controlled and recorded during a 21-min operant session by the Dell computer using the operant software program similar to that of Li and Huston (2002).…”

Section: Brain Stimulation Reward Studymentioning

confidence: 99%

“…A recent study in our laboratory has demonstrated that genetic selection for EtOH preference in at least one set of selected lines does not correlate with enhanced sensitivity to BSR (Woods et al, 2003). Specifically, HAD and lowalcohol-drinking (LAD) rat lines exhibit a remarkably similar sensitivity to BSR across a number of frequencies, current levels, and reinforcement schedules using the simple rate-intensity paradigm.…”

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confidence: 98%

“…In addition, the current study also compared the reinforcing efficacy of BSR with operantmotivated responding for a highly palatable sucrose (10% w/v) solution. Previous research compared the reinforcing actions of saccharin/sucrose only in home cage studies in P and NP rats (for review, see Woods et al, 2003). However, more qualitative analyses of the relation in the operant chamber in P and NP rats have not been performed.…”

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confidence: 99%

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Brain Stimulation Reward Performance and Sucrose Maintained Behaviors in Alcohol-Preferring and -Nonpreferring Rats

Eiler

Woods

Masters

et al. 2005

Alcoholism: Clinical & Experimental Research

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The results demonstrate that responding for BSR is not associated with EtOH preference, insofar as alcohol-preferring and -nonpreferring rats respond similarly under an array of reinforcement schedules and current intensities. In contrast, genetic selection for EtOH preference is highly associated with responding for a palatable sucrose reward, and the relation increases as the reward cost for the sucrose increases. These findings suggest that similar/overlapping mechanisms of action regulate the reinforcing properties of EtOH and sucrose but that overlapping yet distinct neuronal mechanism may modulate the reward characteristics of BSR and EtOH preference.

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confidence: 86%

Section: Brain Stimulation Reward Studymentioning

confidence: 99%

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confidence: 98%

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confidence: 99%

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Brain Stimulation Reward Performance and Sucrose Maintained Behaviors in Alcohol-Preferring and -Nonpreferring Rats

Eiler

Woods

Masters

et al. 2005

Alcoholism: Clinical & Experimental Research

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“…Differences in sensitivity to or preference for salty taste have been reported in subjects with a paternal history of alcohol dependence relative to control subjects with no paternal history (Scinska et al 2001). A positive association exists between ethanol intake and sweet taste (Stewart et al 1994;Woods et al 2003) involving the gene for T1R3 (Bachmanov et al 2001(Bachmanov et al , 2002Blednov and Harris 2007;Blednov et al 2008;Blizard 2007;Brasser et al 2010;Inoue et al 2004;Lu et al 2005;Nelson et al 2001), a G protein-coupled receptor (GPCR) that combines with another GPCR (T1R2) to function as the broadly tuned, heterodimeric, sweet taste receptor T1R2ϩT1R3 Zhao et al 2003). Alcohol dependence and use also show significant association with the T2R38 gene, a marker for 6-n-propylthiouracil bitterness, and with hT2R16, a gene encoding a taste receptor for the bitter-tasting ␤-glucopyranosides (Duffy et al 2004;Hinrichs et al 2006).…”

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confidence: 99%

Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats

Coleman¹,

Williams²,

Phan³

et al. 2011

Journal of Neurophysiology

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Strain differences between naive, sucrose- and ethanol-exposed alcohol-preferring (P) and alcohol-nonpreferring (NP) rats were investigated in their consumption of ethanol, sucrose, and NaCl; chorda tympani (CT) nerve responses to sweet and salty stimuli; and gene expression in the anterior tongue of T1R3 and TRPV1/TRPV1t. Preference for 5% ethanol and 10% sucrose, CT responses to sweet stimuli, and T1R3 expression were greater in naive P rats than NP rats. The enhancement of the CT response to 0.5 M sucrose in the presence of varying ethanol concentrations (0.5-40%) in naive P rats was higher and shifted to lower ethanol concentrations than NP rats. Chronic ingestion of 5% sucrose or 5% ethanol decreased T1R3 mRNA in NP and P rats. Naive P rats also demonstrated bigger CT responses to NaCl+benzamil and greater TRPV1/TRPV1t expression. TRPV1t agonists produced biphasic effects on NaCl+benzamil CT responses, enhancing the response at low concentrations and inhibiting it at high concentrations. The concentration of a TRPV1/TRPV1t agonist (Maillard reacted peptides conjugated with galacturonic acid) that produced a maximum enhancement in the NaCl+benzamil CT response induced a decrease in NaCl intake and preference in P rats. In naive P rats and NP rats exposed to 5% ethanol in a no-choice paradigm, the biphasic TRPV1t agonist vs. NaCl+benzamil CT response profiles were higher and shifted to lower agonist concentrations than in naive NP rats. TRPV1/TRPV1t mRNA expression increased in NP rats but not in P rats exposed to 5% ethanol in a no-choice paradigm. We conclude that P and NP rats differ in T1R3 and TRPV1/TRPV1t expression and neural and behavioral responses to sweet and salty stimuli and to chronic sucrose and ethanol exposure.

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Amphetamine lowers brain stimulation reward (BSR) threshold in alcohol-preferring (P) and non-preferring (NP) rats: Regulation by D₁ and D₂ receptors in the nucleus accumbens.

Eiler

Masters²,

McKay³

et al. 2006

Experimental and Clinical Psychopharmacology

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Differences in the mesolimbic dopamine (DA) pathway that regulates alcohol preference may also increase sensitivity to the reinforcing effects of other drugs of abuse. In the present study, the curve-shift (rate-frequency) paradigm was used to quantify the interaction of amphetamine with the rewarding effects of lateral hypothalamic brain stimulation reward (BSR) in alcohol-preferring (P) and -nonpreferring (NP) rats. The role of D-sub-1 and D-sub-2 DA receptors of the nucleus accumbens (NAcc) in mediating the reward-potentiating effects of amphetamine was also determined. Animals were tested with randomly administered amphetamine (0.25, 0.75, 1.25 mg/kg ip), DA-receptor antagonists (SCH 23390 [2.0 microg, 5.0 microg]; eticlopride [2.0 microg, 5.0 microg]), or a combination of the 2 (SCH 23390 [2.0 microg, 5.0 microg] + 0.75 mg/kg amphetamine; eticlopride [2.0 microg, 5.0 microg] + 0.75 mg/kg amphetamine). Amphetamine produced comparable dose-related leftward shifts in the rate-frequency function for both P and NP rats, with a greater than 60% reduction observed in BSR threshold. On intervening days, baseline threshold was unaltered between tests and similar between rat lines. Unilateral infusion in the NAcc of either the D-sub-1 or D-sub-2 receptor antagonist produced rightward shifts in the rate-frequency function of amphetamine, completely reversing-attenuating its reward-enhancing effects. The results demonstrate that amphetamine produces similar threshold-lowering effects in both P and NP rats and that the reward-potentiating effects of amphetamine do not correlate with alcohol preference under the conditions of the present study.

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Differential Responding for Brain Stimulation Reward and Sucrose in High–Alcohol‐Drinking (HAD) and Low–Alcohol‐Drinking (LAD) Rats

Cited by 7 publications

References 47 publications

Brain Stimulation Reward Performance and Sucrose Maintained Behaviors in Alcohol-Preferring and -Nonpreferring Rats

Brain Stimulation Reward Performance and Sucrose Maintained Behaviors in Alcohol-Preferring and -Nonpreferring Rats

Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats

Amphetamine lowers brain stimulation reward (BSR) threshold in alcohol-preferring (P) and non-preferring (NP) rats: Regulation by D₁ and D₂ receptors in the nucleus accumbens.

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