J. Neurosci. Res. volume 86, issue 15, P3275-3284 2008 DOI: 10.1002/jnr.21778 View full text
Jacques Borg, Emmanuel Chereul

Abstract: Clinical magnetic resonance imaging (MRI) offers a noninvasive diagnostic tool for neurodegenerative diseases. MRI was performed on mice to investigate a relationship between brain atrophy and overexpression of two genes involved in such diseases, SOD1 (superoxide dismutase) and APP (amyloid precursor protein), which have been associated with pathogenesis of Alzheimer's disease or Down syndrome. Additionaly, we investigated how life span and growth rate were affected by genetic background. T2-weighted MRI made…

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