2015
DOI: 10.1097/wnr.0000000000000366
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Abstract: Peripheral nerve functional recovery after injuries relies on both axon regeneration and remyelination. Both axon regeneration and remyelination require intimate interactions between regenerating neurons and their accompanying Schwann cells. Previous studies have shown that motor and sensory neurons are intrinsically different in their regeneration potentials. Moreover, denervated Schwann cells accompanying myelinated motor and sensory axons have distinct gene expression profiles for regeneration-associated gr… Show more

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Cited by 17 publications
(13 citation statements)
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“…The few existing studies of sex differences in nerve regeneration suggest that regeneration of myelinated neurons occurs more rapidly in females than males (Kovacic et al 2003;Kovacic et al 2004;Kovacic et al 2009). However, Tong and colleagues recently found no sex differences in axon regeneration of axotomized neurons (Tong et al 2015). Our findings support the latter study since after CCI no significant sex-specific transcriptional differences exist in genes known to be involved in axon regeneration and neuron projection development.…”
Section: Similar Gene Expression Changes After Peripheral Nerve Injursupporting
confidence: 91%
“…The few existing studies of sex differences in nerve regeneration suggest that regeneration of myelinated neurons occurs more rapidly in females than males (Kovacic et al 2003;Kovacic et al 2004;Kovacic et al 2009). However, Tong and colleagues recently found no sex differences in axon regeneration of axotomized neurons (Tong et al 2015). Our findings support the latter study since after CCI no significant sex-specific transcriptional differences exist in genes known to be involved in axon regeneration and neuron projection development.…”
Section: Similar Gene Expression Changes After Peripheral Nerve Injursupporting
confidence: 91%
“…The absolute absences of global axonal reinnervation in the lateral plantar skin areas at the early days after sciatic nerve crush (Fig. 2) proved the completeness of axotomy for our sciatic nerve crush surgery as previously reported [8].…”
Section: Discussionsupporting
confidence: 71%
“…Myelin sheaths are critical for the physiological function of peripheral nerves, and enhancing remyelination improves functional recovery (Stassart et al, 2013). Tong et al (2015) found that remyelination is diverse among myelinated motor and sensory nerve fibers. In our study, the mean thickness of the myelin sheath of the medullated fibers in the muscular branch of the femoral nerve was greater than that of the cutaneous branch, indicating that there should be a different standard of the thickness of the myelin sheath to evaluate remyelination of sensory and motor nerve fibers.…”
Section: Discussionmentioning
confidence: 99%