2005
DOI: 10.1111/j.1478-3231.2005.01005.x
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Abstract: While the present findings demonstrate the anti-inflammatory role of IL-4 in preventing the expression of IL-8 by Ac, the regulation of chemokines by anti-inflammatory cytokines is complex and depends on the cellular lineage.

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Cited by 12 publications
(12 citation statements)
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“…Inflammation has been previously connected to the hepatic IDR-causing potential of TVX in vivo in the rat Waring et al, 2006). IL-8 is an important response factor in hepatic injury, and its expression is typically stimulated upon insult (Gómez-Quiroz et al, 2005). For the PHH donors evaluated here, IL-8 expression was down-regulated almost 2-fold, on average, in response to TVX.…”
Section: Genomic Comparison Of Human Hepatocytes and Hepg2 Cellsmentioning
confidence: 74%
See 1 more Smart Citation
“…Inflammation has been previously connected to the hepatic IDR-causing potential of TVX in vivo in the rat Waring et al, 2006). IL-8 is an important response factor in hepatic injury, and its expression is typically stimulated upon insult (Gómez-Quiroz et al, 2005). For the PHH donors evaluated here, IL-8 expression was down-regulated almost 2-fold, on average, in response to TVX.…”
Section: Genomic Comparison Of Human Hepatocytes and Hepg2 Cellsmentioning
confidence: 74%
“…GADD45B (growth arrest and DNA damage-inducible), a stress response factor and cell death regulator (Major and Jones, 2004), was induced, on average, Ͼ12.6-fold in HepG2 cells versus 2.5-fold in PHH. The proinflammatory cytokine, IL-8, a critical factor of hepatocyte repair subsequent to injury (Gómez-Quiroz et al, 2005), was induced 9.4-fold by TVX in HepG2 cells. However, its expression was repressed in TVX-treated PHH.…”
Section: Anova Methods To Discern Similarities and Differences In Expmentioning
confidence: 99%
“…The HepG2 cell line was chosen as a suitable model, due to its intact NF-kB system and its ability to synthesize pro-inflammatory cytokines like IL-8 in response to pro-inflammatory stimuli [26]. To our knowledge there are no inborn errors or mutations in the canonical NF-kB pathway in HepG2 cells [27].…”
Section: Introductionmentioning
confidence: 99%
“…Several reports have been showed that ethanol and its metabolite, Ac, activate NF-κB in HepG2 cells. (Roman et al 1999;Gómez Quiroz 2005).…”
Section: Discussionmentioning
confidence: 98%