Differential modulation of clock gene expression in the suprachiasmatic nucleus, liver and heart of aged mice

The aging clock: circadian rhythms and later life

“…These PER2 data conflict with other reports of no differences in SCN rhythms of expression of Period genes Per1 and Per2 between young and old animals (29,84,92). However, age-associated reductions were found in the overall expression of Clock and Bmal1 transcripts in the hamster (17-20 months) and mouse (22 months) SCN (30,93).…”

Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster

“…Expression of the per gene is robustly rhythmic in the heads of young flies but significantly declines in older flies (Krishnan et al, 2009). In Drosophila , per 01 mutations exhibit accelerated aging (Krishnan et al, 2009, Krishnan et al, 2012, Rakshit et al, 2012) and in mammals, disruption in clock gene expression results in faster aging (Bonaconsa et al, 2014, Kolker et al, 2003, Musiek et al, 2013) decreased lifespan (Davidson et al, 2006, Dubrovsky et al, 2010, Kondratov et al, 2006, Yu and Weaver, 2011). Disruption of the circadian clock through jet lag paradigms also increases mortality in aged mice (Davidson et al, 2006).…”

Aging and Circadian Rhythms

“…In a study of young and older mice, the amplitude of Per2 expression (but not expression of Per1, Clock, or Cry) was found to be reduced in the SCN of older mice [160]. A more comprehensive study of clock gene expression in young and older mice found age-related differences in expression of Per2, Bmal1, Rev-erbα, Dbp, and Dec1 expression in the SCN of the older mice [161]. Thus, even with the limited number of studies thus far, there is evidence that the molecular clockwork itself may be altered in aging, although much more research in this area remains to be done.…”