Differential influences of dietary sodium on blood pressure regulation based on race and sex

Robinson, Austin T.; Wenner, Megan M.; Charkoudian, Nisha

doi:10.1016/j.autneu.2021.102873

Cited by 12 publications

(10 citation statements)

References 140 publications

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“…To test this hypothesis, we used telemetry to measure 24-hour blood pressure. It is well-established that males have higher blood pressure than premenopausal females by ∼10mmHg in both humans 2-14 and mice 1 . In agreement with this, we find that Olfr558 WT males exhibit significantly higher blood pressure than WT females, including mean arterial pressure (MAP) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Sex differences in blood pressure in normotensive subjects are well-documented in both animal models 1 and humans [1][2][3][4][5][6][7][8][9][10][11][12][13][14]55 . In humans, 24 hr ambulatory blood pressure measurements show that men have higher systolic blood pressure (~10 mmHg) than women from the ages of 20-70; this difference is absent in those above the age of 70 55 .…”

Section: Sex Differences In Blood Pressurementioning

confidence: 99%

“…Sex differences in blood pressure are well-established, with premenopausal women having lower blood pressure than men by ~10mmHg [1][2][3][4][5][6][7][8][9][10][11][12][13][14] . These sex differences are modeled well in C57BL/6 mice, where females have mean arterial pressure ~10 mmHg lower than males by telemetry 1 .…”

Section: Introductionmentioning

confidence: 99%

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An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure

Choi

Gupta

et al. 2022

Preprint

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Sex differences in blood pressure are well-established, with premenopausal women having lower blood pressure than men by ~10mmHg; however, the underlying mechanisms are not fully understood. We report here that olfactory receptor 558 (Olfr558), which has not previously been studied in non-olfactory tissues, localizes to vascular smooth muscle cells in numerous tissues including the kidney and heart. In the kidney, Olfr558 colocalizes with renin (a hormone that plays a key role in blood pressure regulation) in the renal afferent arteriole. Based on the localization of Olfr558, we hypothesized that Olfr558 plays a role in blood pressure regulation. We find that sex differences in blood pressure are intact in Olfr558 wildtype (WT) mice, but, are absent in Olfr558 knockout (KO) mice. We find that male KO mice have lowered diastolic blood pressure, decreased renin expression and activity, and altered vascular reactivity. Female KO mice exhibit increased blood pressure and increased pulse wave velocity, indicating increased vascular stiffness. The human ortholog of Olfr558, OR51E1, was previously identified as a locus associated with diastolic blood pressure. We report here that a rare OR51E1 missense variant has a statistically significant sex interaction effect with diastolic blood pressure, increasing diastolic blood pressure in women but decreasing it in men. In addition, we characterize how two different clinically relevant OR51E1 variants influence OR51E1 signaling in vitro. In sum, our findings demonstrate an evolutionarily conserved role for Olfr558/OR51E1 to mediate sex differences in blood pressure by altering renin, vascular reactivity, and arterial stiffness.

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Section: Resultsmentioning

confidence: 99%

Section: Sex Differences In Blood Pressurementioning

confidence: 99%

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An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure

Choi

Gupta

et al. 2022

Preprint

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“…The prevalence of hypertension was higher among boys and lower among girls compared with a study in Suzhou, China, where the prevalence of hypertension in 13–18-year-old adolescents was 25.5% in boys and 24.2% in girls ( 41 ). This was attributed to the different races and dietary habits ( 42 ). Goulding et al ( 43 ) found that elevated BP was most prevalent among US non-Latino Black children than those among US non-Latino White children based on the National Health and Nutrition Examination Survey 2011–2018 data.…”

Section: Discussionmentioning

confidence: 99%

The associations between problematic smartphone use and blood pressure among 2,573 aged 9–17 years students in Shanghai, China

Lan

et al. 2022

Front. Public Health

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ObjectivesThis study aimed to (1) examine the cross-sectional association between problematic smartphone use (PSU) and blood pressure (BP) in children and adolescents and (2) determine whether the association between PSU and BP differs by the grade of students.MethodsWe recruited a total of 2,573 participants from 14 schools in Shanghai by a two-stage sampling method. We derived BP data from the participant's most recent medical examination data, including systolic blood pressure (SBP) and diastolic blood pressure (DBP). We measured PSU by a modified PSU Classification Scale. We also assessed demographic characteristics, body mass index, behavioral variables, and physiological characteristics.ResultsHigh school students had higher BP and PSU scores than primary and middle school students. PSU on the dimension of information collection was associated positively with both SBP and DBP among primary and middle school students, with the β (95% CI) values of 0.282 (0.018, 0.546) and 0.229 (0.031, 0.427). Meanwhile, the dimension of the relationship of social network was associated positively with SBP among primary and middle school students, with a β (95% CI) value of 0.390 (0.062, 0.717). PSU on the dimension of information collection was positively associated with the development of high BP, with a OR (95% CI) value of 1.072 (1.011, 1.137) among primary and middle school students.ConclusionsPSU might be a potential correlate of high BP among school-age children and adolescents. The associations between PSU and BP differed by the grade of students as well as according to the four dimensions of PSU.

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“…Furthermore, other models of salt sensitivity show that males have a more severe phenotype to high salt diets and so this highlights the complexity and wider array of mechanisms that contribute to the mechanisms of sodium homeostasis. 9 , 10 …”

Section: A Perspective On 'Endothelial Cullin3 Mutation Impairs Nitri...mentioning

confidence: 99%

Uncovering the Complexities of Salt Sensitivity

Pollock

2022

Function

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Differential influences of dietary sodium on blood pressure regulation based on race and sex

Cited by 12 publications

References 140 publications

An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure

An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure

The associations between problematic smartphone use and blood pressure among 2,573 aged 9–17 years students in Shanghai, China

Uncovering the Complexities of Salt Sensitivity

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