Differential in Vitro Suppressive Effects of Steroids on Leukocyte Phagocytosis in Two Teleosts, Tilapia and Common Carp

Law, Wan-Yu; Chen, Wen‐Hsiung; Song, Yen-Ling; Dufour, Sophie; Chang, Ching‐Fong

doi:10.1006/gcen.2000.7593

Cited by 109 publications

(68 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The possibility exists that this response can be abolished by a more prolonged treatment or higher HC doses. DiVerent eVects of cortisol phisiological or pharmacological in vitro doses on phagocytes, as reported by other authors (Esteban et al, 2004;Law et al, 2001), could depend on the used Wsh species, tissue or organ examined, and assays used for revealing modulation of the phagocyte activity.…”

Section: Discussionmentioning

confidence: 73%

“…In Wsh, cortisol (hydrocortisone) is the major corticosteroid with both GC and MC activities. In vivo and in vitro experiments have shown immunosuppressive property of cortisol in reducing the normal ability of striped bass phagocytes to generate a respiratory burst response, assayed as chemiluminescence (CL) reaction when exposed to bacteria or phorbolester (Stave and Roberson, 1985), in modulating apoptosis and proliferation of carp B lymphocytes (Verburg-Van Kemenade et al, 1999), in putting down mitogen-induced proliferation of rainbow trout lymphocytes (Tripp et al, 1987), and in suppressing tilapia leukocyte phagocytosis (Law et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the in vitro chemiluminescence response to zymosan

Vizzini

Vazzana

Cammarata

et al. 2007

General and Comparative Endocrinology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the in vitro chemiluminescence response to zymosan

Vizzini

Vazzana

Cammarata

et al. 2007

General and Comparative Endocrinology

View full text Add to dashboard Cite

“…17b-oestradiol (E 2 ) and NP (Madsen et al 1997, Vijayan et al 2001, Arsenault et al 2004, Madsen et al 2004, McCormick et al 2005), immune function (e.g. E 2 (Wang & Belosevic 1994, Hou et al 1999, Law et al 2001, EE 2 (Law et al 2001)), the stress response (e.g. E 2 (Pottinger et al 1996), NP (Magliulo et al 2002), methoxychlor (Magliulo et al 2002)) and embryonic development (e.g.…”

Section: Introductionmentioning

confidence: 99%

Multiple molecular effect pathways of an environmental oestrogen in fish

Filby¹,

Thorpe²,

Tyler³

2006

Journal of Molecular Endocrinology

129

View full text Add to dashboard Cite

Complex interrelationships in the signalling of oestrogenic effects mean that environmental oestrogens present in the aquatic environment have the potential to disrupt physiological function in fish in a more complex manner than portrayed in the present literature. Taking a broader approach to investigate the possible effect pathways and the likely consequences of environmental oestrogen exposure in fish, the effects of 17b-oestradiol (E 2 ) were studied on the expression of a suite of genes which interact to mediate growth, development and thyroid and interrenal function (growth hormone GH (gh), GH receptor (ghr ), insulin-like growth factor (IGF-I) (igf1), IGF-I receptor (igf1r ), thyroid hormone receptors-a (thra) and -b (thrb) and glucocorticoid receptor (gr )) together with the expression analyses of sex-steroid receptors and ten other genes centrally involved in sexual development and reproduction in fathead minnow (fhm; Pimephales promelas). Exposure of adult fhm to 35 ng E 2 /l for 14 days induced classic oestrogen biomarker responses (hepatic oestrogen receptor 1 and plasma vitellogenin), and impacted on the reproductive axis, feminising 'male' steroidogenic enzyme expression profiles and suppressing genes involved in testis differentiation. However, E 2 also triggered a cascade of responses for gh, ghr, igf1, igf1r, thra, thrb and gr in the pituitary, brain, liver, gonad and gill, with potential consequences for the functioning of many physiological processes, not just reproduction. Molecular responses to E 2 were complex, with most genes showing differential responses between tissues and sexes. For example, igf1 expression increased in brain but decreased in gill on exposure to E 2 , and responded in an opposite way in males compared with females in liver, gonad and pituitary. These findings demonstrate the importance of developing a deeper understanding of the endocrine interactions for unravelling the mechanisms of environmental oestrogen action and predicting the likely health consequences.

show abstract

“…However, measures of immunocompetence have been found to be suppressed to a similar extend by both T and KT (Slater and Schreck, '93;Slater et al, '95a;Slater and Schreck, '97;Hou et al, '99;Law et al, 2001;Yamaguchi et al, 2001;Watanuki et al, 2002;Saha et al, 2003). Moreover, receptor activity in the cytosol seemed to be more specific for T, while KT and T bound with similar affinity to whole leukocytes (Slater et al,'95b;Slater and Schreck,'98).…”

mentioning

confidence: 98%

Regulation of immunocompetence by different androgen metabolites in a blenny with alternative reproductive tactics

et al. 2006

View full text Add to dashboard Cite

In Parablennius parvicornis, small reproductive males with relatively low expression of secondary sexual characters (MÀ morphotype) parasite on the parental investment of the larger nest-holder males which have fully developed secondary sexual characters (M1 morphotype). In comparison with M1 males, MÀ males have relatively low levels of androgens while having high blood cell percentages of lymphocytes and antigen responsiveness. Here we test the hypothesis that androgens are a causal factor for these differences in immunocompetence between morphotypes. After drawing an initial blood sample, males received a silastic implant containing either oil only (C), or oil with testosterone (T) or 11-ketotestosterone (KT). Males were re-caught 2 weeks later for drawing of the final blood sample. KT but not T induced the development of secondary sexual characters in MÀ males. MÀ males treated with KT showed lower swimming activity than the males treated with T or C implants, suggesting that KT also mediates behavioral changes in MÀ males. As expected, blood cell percentages of lymphocytes, but not of granulocytes, were higher in MÀ males than in M1 males. Overall, lymphocyte percentages increased in the C group which might have been a response to the surgery/treatment. In concordance with the hypothesis, lymphocyte percentages were suppressed in males treated with T in comparison with controls. However, no significant change was found in KT-treated males. This suggests that androgens modulate central, morphological and immunological traits by partly independent androgen mechanisms in P. parvicornis. J. Exp. Zool. 305A:986-994, 2006.

show abstract

Differential in Vitro Suppressive Effects of Steroids on Leukocyte Phagocytosis in Two Teleosts, Tilapia and Common Carp

Cited by 109 publications

References 43 publications

Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the in vitro chemiluminescence response to zymosan

Peritoneal cavity phagocytes from the teleost sea bass express a glucocorticoid receptor (cloned and sequenced) involved in genomic modulation of the in vitro chemiluminescence response to zymosan

Multiple molecular effect pathways of an environmental oestrogen in fish

Regulation of immunocompetence by different androgen metabolites in a blenny with alternative reproductive tactics

Contact Info

Product

Resources

About