Differential impact of acute hypoxia on event related potentials: impaired task-irrelevant, but preserved task-relevant processing and response inhibition

Altbäcker, Anna; Takács, Endre; Barkaszi, Irén; Kormos, Tamás; Czigler, István; Balázs, László

doi:10.1016/j.physbeh.2019.03.022

Cited by 13 publications

(9 citation statements)

References 48 publications

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“…Previous work involving the P300 signal has shown that the P3b component, when actively elicited in response to a foreground target detection task, is sensitive to hypoxia exposure (32,43). Whereas these prior studies have examined the P3b subcomponent in response to correctly identified task-relevant target stimuli (and required an active response on the part of the participant), the present data represent the first report showing that even passively elicited P3a in response to background, task-irrelevant, sensory stimuli is also disrupted by hypoxia.…”

Section: Discussionmentioning

confidence: 99%

“…The results of one early study of an active auditory target detection task showed evidence of a delayed latency of the P3b component to target stimuli that corresponded to a lag in RT to those auditory stimuli (32). More recently, Altbäcker et al (43) assessed the sensitivity of three variants of the P300 component (i.e., Target P3, No Go P3, and Novelty P3) to hypoxia evoked in response to a modified continuous performance task. Similar to that found by Fowler and Lindeis (32), these components were elicited via an active target detection task while participants attended to a continuous stream of letters.…”

Section: Introductionmentioning

confidence: 99%

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Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States

Seech

Funke²,

Sharp

et al. 2020

Front. Psychiatry

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The ability to detect novelty in our environment is a critical sensory function. A reliable set of event-related potentials (ERP), known as the auditory deviance response (ADR), are elicited in the absence of directed attention and indexes functionally relevant networks. The ADR consists of three peaks: mismatch negativity (MMN), P3a, and reorienting negativity (RON) that are sequentially evoked in response to unattended changes in repetitive background stimulation. While previous studies have established the ADR's sensitivity to a range of pharmacologic and nonpharmacologic interventions and are leading candidate biomarkers of perturbations of the central nervous system (CNS), here we sought to determine if ADR peaks are sensitive to decreases in breathable oxygen. Participants performed a visuomotor tracking task while EEG was recorded during two 27-min sessions. The two sessions differed in the amount of environmental oxygen available: 10.6% O 2 (hypoxia) versus 20.4% O 2 (normoxia). ERPs were measured while a series of identical, or "standard," tones combined with occasional "oddball," tones, were presented. MMN, P3a, and RON were assessed in response to the oddball compared to the standard stimuli. Behavioral impairment during hypoxia was demonstrated by a deficit in tracking performance compared to the normoxia condition. Whereas no changes were detected in the MMN or RON, the amplitude of the P3a component was significantly reduced during hypoxia compared to normoxia, within the first 9 min of exposure. To our knowledge, this is the first study to demonstrate the effect of low oxygen exposure on passively elicited neural measures of early sensory processing. This study demonstrates that passively elicited EEG measures, reflecting preattentive auditory processing, are disrupted by acute hypoxia. Results have implications for the development of biomarkers for the noninvasive assessment of CNS perturbations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States

Seech

Funke²,

Sharp

et al. 2020

Front. Psychiatry

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“…Rather, under these circumstances, hypoxia may impair the metabolism of neurotransmitters ( Gibson et al, 1981 ), although impairment to other metabolic factors is likely. These derangements in cerebral metabolism can be detected by electrophysiological markers, such as EEG ( Kraaier et al, 1988 ; Malle et al, 2016 ; Altbäcker et al, 2019 ; Rice et al, 2019 ), particularly at a SaO 2 of ≤75% or PaO 2 of ≤40 mmHg ( Goodall et al, 2014 ). Nevertheless, simultaneous performance of cognitive tasks may negate reductions in EEG power ( Malle et al, 2016 ), which would make it difficult to evaluate the magnitude of impairment to hypoxia-induced cerebral metabolism in operational environments, such as when piloting an aircraft.…”

Section: Hypoxia Brain Function and Performancementioning

confidence: 99%

Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives

Shaw

Cabre²

2021

Front. Physiol.

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Acute hypobaric hypoxia (HH) is a major physiological threat during high-altitude flight and operations. In military aviation, although hypoxia-related fatalities are rare, incidences are common and are likely underreported. Hypoxia is a reduction in oxygen availability, which can impair brain function and performance of operational and safety-critical tasks. HH occurs at high altitude, due to the reduction in atmospheric oxygen pressure. This physiological state is also partially simulated in normobaric environments for training and research, by reducing the fraction of inspired oxygen to achieve comparable tissue oxygen saturation [normobaric hypoxia (NH)]. Hypoxia can occur in susceptible individuals below 10,000 ft (3,048 m) in unpressurised aircrafts and at higher altitudes in pressurised environments when life support systems malfunction or due to improper equipment use. Between 10,000 ft and 15,000 ft (4,572 m), brain function is mildly impaired and hypoxic symptoms are common, although both are often difficult to accurately quantify, which may partly be due to the effects of hypocapnia. Above 15,000 ft, brain function exponentially deteriorates with increasing altitude until loss of consciousness. The period of effective and safe performance of operational tasks following exposure to hypoxia is termed the time-of-useful-consciousness (TUC). Recovery of brain function following hypoxia may also lag beyond arterial reoxygenation and could be exacerbated by repeated hypoxic exposures or hyperoxic recovery. This review provides an overview of the basic physiology and implications of hypoxia for military aviation and discusses the utility of hypoxia recognition training.

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“…High-altitude environments can affect human cognitive function even at 1500 m [ 3 , 4 , 5 , 6 ]. The effects of high-altitude exposure, especially at very high altitudes (>4000 m), on human cognitive function have been relatively well investigated in previous studies, with many reported executive function impairments [ 7 , 8 , 9 ]. However, very few studies have examined the effects of exposure to moderate altitudes (2000 m–3000 m) on cognitive function and brain activity, even though the majority of people living at high altitudes live in this altitude range.…”

Section: Introductionmentioning

confidence: 99%

Effects of Long-Term Exposure to 2260 m Altitude on Working Memory and Resting-State Activity in the Prefrontal Cortex: A Large-Sample Cross-Sectional Study

Chen

Zhou

et al. 2022

Brain Sciences

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It has been well established that very-high-altitude (>4000 m) environments can affect human cognitive function and brain activity. However, the effects of long-term exposure to moderate altitudes (2000–3000 m) on cognitive function and brain activity are not well understood. In the present cross-sectional study, we utilized an N-back working memory task and resting-state functional near-infrared spectroscopy to examine the effects of two years of exposure to 2260 m altitude on working memory and resting-state brain activity in 208 college students, compared with a control group at the sea level. The results showed that there was no significant change in spatial working memory performance after two years of exposure to 2260 m altitude. In contrast, the analysis of resting-state brain activity revealed changes in functional connectivity patterns in the prefrontal cortex (PFC), with the global efficiency increased and the local efficiency decreased after two years of exposure to 2260 m altitude. These results suggest that long-term exposure to moderate altitudes has no observable effect on spatial working memory performance, while significant changes in functional connectivity and brain network properties could possibly occur to compensate for the effects of mild hypoxic environments. To our knowledge, this study is the first to examine the resting state activity in the PFC associated with working memory in people exposed to moderate altitudes.

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Differential impact of acute hypoxia on event related potentials: impaired task-irrelevant, but preserved task-relevant processing and response inhibition

Cited by 13 publications

References 48 publications

Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States

Impaired Sensory Processing During Low-Oxygen Exposure: A Noninvasive Approach to Detecting Changes in Cognitive States

Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives

Effects of Long-Term Exposure to 2260 m Altitude on Working Memory and Resting-State Activity in the Prefrontal Cortex: A Large-Sample Cross-Sectional Study

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