Differentialin vitroinhibition studies of some cerium vanadate derivatives on xanthine oxidase

Abstract

In this preliminary study, a new series of some cerium vanadate derivatives have been investigated as new type of inhibitors of xanthine oxidase (XO; E.C 1.17.3.2). XO is a superoxideproducing enzyme found normally in serum and the lungs, and its activity is concerned with several important health problems such as gout, severe liver damage, vascular dysfunction and injury, oxidative eye injury and renal failure. In this study, we present a critical overview of the effects of these novel type agents on XO with comparing the efficacy and safety profiles of allopurinol, the efficient classical inhibitor of XO.

Do CO2and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients

“…XO, an enzyme containing iron and molybdenum, catalyses the xanthine oxidation of hypoxanthine and the uric acid oxidation of xanthine 24 . XO is usually found in the liver, lung, kidney, heart, brain, and plasma 25 , 26 and causes the formation of reactive oxygen species by the production of superoxide anion radicals 27 .…”

Gebelikte Enzimler: Sitozolik Karbonik Anhidraz, Katalaz, Paraoksonaz 1 ve Ksantin Oksidaz Düzeyleri

“…xanthine, and xanthine to uric acid. [13][14][15] XO is commonly found in the liver, lung, kidney, heart, brain and in the plasma. 16,17 XO produces reactive oxygen species by producing superoxide anion radicals.…”

Optimization of doping process parameters of cerium vanadates doped with Be, Mg, Ca, Sr and Ba ions

“…Rao and Palanna synthesized cerium orthovanadate for the first time via conventional solid-state ceramic method, in 1995 (15), and investigated electrochemical properties of the material after four years (16). Our research group synthesized cerium vanadate by innovative microwave method using cerium sulfate and vanadium(V) oxide (17), and applied this compound and derivatives against xanthine oxidase as inhibitor (18). Since the 2000s, doping processes of cerium orthovanadate with rare earths, heavy metal, alkaline and alkaline earth metals have been studied (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”