volume 66, issue 6, P3966-3970 1992
DOI: 10.1128/jvi.66.6.3966-3970.1992
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A Chapel, A Bensussan, E Vilmer, D Dormont

Abstract: By using cloning methodology, 13 CD4+, CD8-, CD45RO+, and CD29+ clones, isolated from human immunodeficiency virus (HIV)-negative donors, have been characterized and tested regarding their susceptibility to two strains of HIV type 1 (HIV-1). Infected clones possess integrated provirus. Only six are able to replicate HIV-1, while seven may normally grow without cytopathic effect and without viral replication. These results argue that all CD4+ lymphocyte clones may be infectable but that a heterogeneity exists r…

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