Differential expression profile of long non‐coding RNAs in human thoracic aortic aneurysm

Li, Yang; Liu, Yang; Liu, Suxuan; Wu, Feng; Li, Songhua; Yang, Fan; Gu, Ying; Xu, Zhiyun; Wang, Guokun

doi:10.1002/jcb.26670

Cited by 17 publications

(14 citation statements)

References 25 publications

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“…LncRNA-related VSMC dysfunction and ECM degradation were suggested as potential mechanisms according to recent data. Microarray profile analysis revealed that hundreds and thousands of lncRNAs are involved in human thoracic aortic aneurysm (TAA) development, such as Lnc-HLTF-5 [44], HIF1A-AS1, RP11-465L10.10, and CTD-2184D3.5 [45], which might play roles in regulating the expression of MMP-9 in aortic tissue and then facilitate the expansionary remodeling. HIF1alpha-antisense RNA 1 (HIF1A-AS1) was the first reported lncRNA participating in TAA pathogenesis [46].…”

Section: The Regulatory Role Of Lncrna In Cardiac Remodelingmentioning

confidence: 99%

Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature

Zhou

Wang

Yang

et al. 2019

BioMed Research International

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Cardiac remodeling is a self-regulatory response of the myocardium and vasculature under the stressful condition. Cardiomyocytes (CMs), vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and cardiac fibroblasts (CFs) are all involved in this process, characterized by change of morphological structures and mechanical/chemical activities as well as metabolic patterns. Despite current development of consciousness, the control of cardiac remodeling remains unsatisfactory, and to further explore the underlying mechanism and seek the optimal therapeutic targets is still the urgent need in clinical practice. It is now emerging that long noncoding RNAs (lncRNAs) play key regulatory roles in these adverse responses: lncRNA TUG1, AK098656, TRPV1, GAS5, Giver, and Lnc-Ang362 have been indicated in hypertension-related vascular remodeling, H19, TUG1, UCA1, MEG3, APPAT, and lincRNA-p21 in atherosclerosis (AS), and HIF1A-AS1 and Lnc-HLTF-5 in aortic aneurysm (AA). In addition, Neat1, AK139328, APF, CAIF, AK088388, CARL, MALAT1, HOTAIR, XIST, and NRF are involved in postischemia myocardial remodeling, while Mhrt, Chast, CHRF, ROR, H19, Plscr4, and MIAT are involved in myocardial hypertrophy, and MALAT1, wisper, MEG3, and H19 are involved in extracellular matrix (ECM) reconstitution. Signaling to specific miRNAs by acting as endogenous sponge (ceRNA) was the main form that regulates the target gene expression during cardiac remodeling. This review will underline the updates of lncRNAs and lncRNA-miRNA interactions in maladaptive remodeling and also cast light on their potential roles as therapeutic targets, hoping to provide supportive background for following research.

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Section: The Regulatory Role Of Lncrna In Cardiac Remodelingmentioning

confidence: 99%

Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature

Zhou

Wang

Yang

et al. 2019

BioMed Research International

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“…An increasing number of studies have demonstrated the direct role of lncRNAs in the pathogenesis of various human diseases including tumors, inflammatory, cardiovascular, and immunological diseases [ 3 , 5 ]. In many studies, the regulatory mechanism of lncRNAs in aortic aneurysms was also shown, which was directly associated with the formation, growth and dissection of the aorta ( Table 1 ) [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. In recent years, increasing studies have focused on role lncRNAs in the pathogenesis of IAs.…”

Section: Lncrnas and Iasmentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Intracranial Aneurysms and Subarachnoid Hemorrhage

Gareev

Beylerli

Aliev

et al. 2020

Life

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Intracranial aneurysms (IAs) represent the most complex and relevant problem of modern neurology and neurosurgery. They serve as one of the main causes of non-traumatic subarachnoid hemorrhage (SAH), causing up to 85% of all cases of intracranial hemorrhage, which is associated with frequent disability and high mortality among patients. Unfortunately, the molecular mechanisms of the development and rupture of IAs are still under study. Long non-coding RNAs (lncRNAs) are non-coding RNAs that typically have a length of more than 200 nucleotides. It is known that lncRNAs regulate many processes, such as transcription, translation, cell differentiation, regulation of gene expression, and regulation of the cell cycle. In recent years, a lot of evidence has established their role in human diseases from oncology to cardiovascular disease. Recent studies have shown that lncRNAs may be involved in the pathogenesis of IAs. The study of lncRNAs and its targets in various pathological conditions of a person is a rapidly developing field, and it is likely that the knowledge obtained from these studies regarding the pathogenesis of intracranial aneurysms will have the potential to use lncRNAs in therapy, as well as in the diagnosis and prediction of high aneurysms risk of rupture.

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“…So far, H19 is the only lncRNA found to be involved in AAA formation (71). Although involvement in vascular disease has been demonstrated for a number of other lncRNAs (5,70,73), distinctive functional roles in AAA formation have not been proven. Knockdown of H19 using antisense oligonucleotides led to a significant reduction of aneurysm formation in two different murine AAA models.…”

Section: Long Noncoding Rnamentioning

confidence: 99%

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease

Knappich

Spin

Eckstein

et al. 2020

Antioxidants & Redox Signaling

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Significance: Abdominal aortic aneurysm (AAA) is a potentially fatal condition, featuring the possibility of high-mortality rupture. To date, prophylactic surgery by means of open surgical repair or endovascular aortic repair at specific thresholds is considered standard therapy. Both surgical options hold different risk profiles of short-and long-term morbidity and mortality. Targeting early stages of AAA development to decelerate disease progression is desirable. Recent Advances: Understanding the pathomechanisms that initiate formation, maintain growth, and promote rupture of AAA is crucial to developing new medical therapeutic options. Inflammatory cells, in particular macrophages, have been investigated for their contribution to AAA disease for decades, whereas evidence on lymphocytes, mast cells, and neutrophils is sparse. Recently, there has been increasing interest in noncoding RNAs (ncRNAs) and their involvement in disease development, including AAA. Critical Issues: The current evidence on myeloid cells and ncRNAs in AAA largely originates from small animal models, making clinical extrapolation difficult. Although it is feasible to collect surgical human AAA samples, these tissues reflect end-stage disease, preventing examination of critical mechanisms behind early AAA formation. Future Directions: Gaining more insight into how myeloid cells and ncRNAs contribute to AAA disease, particularly in early stages, might suggest nonsurgical AAA treatment options. The utilization of large animal models might be helpful in this context to help bridge translational results to humans. Antioxid. Redox Signal. 00, 000-000.

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Differential expression profile of long non‐coding RNAs in human thoracic aortic aneurysm

Cited by 17 publications

References 25 publications

Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature

Long Noncoding RNAs in Pathological Cardiac Remodeling: A Review of the Update Literature

The Role of Long Non-Coding RNAs in Intracranial Aneurysms and Subarachnoid Hemorrhage

Involvement of Myeloid Cells and Noncoding RNA in Abdominal Aortic Aneurysm Disease

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