Differential Expression of Vascular Endothelial Growth Factor (Vascular Permeabilty Factor) Forms in Rat Tissues

Bacic, Mima; Edwards, Nancy A.; Merrill, Marsha J.

doi:10.3109/08977199509003209

Cited by 126 publications

(90 citation statements)

References 29 publications

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“…This is a novel finding because earlier studies had shown that VEGF 165 mRNA expression is higher than VEGF 189 in the brain and muscle of mice and rat, animals found at sea level (Bacic et al, 1995, Ng et al, 2001. The recent study (Zheng et al, 2011) found that the microvessel density is significantly increased in the pika brain compared with sea-level rat brain (602.…”

Section: Discussionmentioning

confidence: 69%

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VEGF₁₈₉Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

Guo

Ren

et al. 2013

High Altitude Medicine & Biology

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expression is highly related to adaptation of the plateau pika (Ochotona curzoniae) inhabiting high altitudes. High Alt Med Biol 14:395-404, 2013.-The plateau pika (Ochotona curzonia) has adapted to high-altitude hypoxia during evolution. Higher microvessel density in specific tissues and a blunted hypoxic pulmonary vasoconstriction response are the critical components of this adaptation. VEGF, vascular endothelial growth factor, has proved to be a key regulator of angiogenesis in response to tissue hypoxia and to play an important role in vascular vasodilation. However, the role of VEGF in adaptation to high-altitude hypoxia in the plateau pika remains unknown. In this study, we cloned cDNAs for VEGF 165 and VEGF 189 and examined their expression in pikas inhabiting altitudes of 3200 and 4750 m. Phylogenetic analysis reveals that pika VEGF 165 and VEGF 189 are evolutionarily conserved. Real-time PCR analysis demonstrates that VEGF 165 and VEGF 189 display tissue and altitude-specific expression patterns. Interestingly, we found that the levels of VEGF 189 mRNA are significantly higher than those of VEGF 165 in the brain and muscle tissues of the pika, which is different from what was previously observed in sea-level mammals. VEGF 189 mRNA levels in brain, muscle, and lung of the pika increased with increased habitat altitude, whereas VEGF 165 shows less change. Our study suggests an important role for VEGF 189 in adaptation to hypoxia by the plateau pika in the highaltitude environment.

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Section: Discussionmentioning

confidence: 69%

“…VEGF 188 is the most abundant isoform in lung and heart, whereas VEGF 164 is more highly expressed in murine muscle, brain, liver, spleen, and kidney (Bacic et al, 1995, Ng et al, 2001. Watkins et al (1999) reported that VEGF 189 is most highly expressed in rabbit lung, whereas VEGF 165 is most abundant in liver, spleen, and kidney.…”

Section: Discussionmentioning

confidence: 99%

VEGF₁₈₉Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

Guo

Ren

et al. 2013

High Altitude Medicine & Biology

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“…Not all VEGF isoforms are present in all cells; some cell types could produce several VEGF forms simultaneously (39,40). It has been reported that each form of VEGF offers advantages in different situations and, therefore, the simultaneous production of several different forms may ensure a balanced angiogenic response under diverse circumstances (37).…”

Section: Discussionmentioning

confidence: 99%

Angiogenic role for glycodelin in tumorigenesis

Song

Ramaswamy

Ramachandran

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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Angiogenesis plays an important role in neovascularization in tumors. Glycodelin, a hormone-responsive protein, has been detected in tumors of reproductive organs and is found in high levels in the plasma of subjects with gynecological malignancies. Glycodelin is also found in the endothelial cells of the umbilical cord and in the blood vessels of tumors. In this study, we tested whether glycodelin-rich amniotic fluid and a synthetic peptide derived from the sequence of glycodelin peptide (

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“…It is a homodimer ) that occurs in ®ve isoforms, speci®cally: VEGF 121 , VEGF 145 , VEGF 165 , VEGF 189 and VEGF 206 , as a result of alternative splicing from a single gene (Houck et al, 1991). Of these, VEGF 121 and VEGF 165 are the most abundant and potent isoforms (Bacic et al, 1995). While VEGF 121 lacks an ECM-binding domain and is secreted only in medium, VEGF 165 is found to be both cell-associated and secreted in medium (Park et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

et al. 2001

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Differential Expression of Vascular Endothelial Growth Factor (Vascular Permeabilty Factor) Forms in Rat Tissues

Cited by 126 publications

References 29 publications

VEGF₁₈₉Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

VEGF₁₈₉Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

Angiogenic role for glycodelin in tumorigenesis

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

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Differential Expression of Vascular Endothelial Growth Factor (Vascular Permeabilty Factor) Forms in Rat Tissues

Cited by 126 publications

References 29 publications

VEGF189Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

VEGF189Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

Angiogenic role for glycodelin in tumorigenesis

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

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Product

Resources

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VEGF₁₈₉Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes

VEGF₁₈₉Expression Is Highly Related to Adaptation of the Plateau Pika (Ochotona curzoniae) Inhabiting High Altitudes