Differential expression of heparin-binding epidermal growth factor-like growth factor in the rat ovary

Pan, Bochen; Sengoku, Kazuo; Takuma, Naoyuki; Goishi, Katsutoshi; Horikawa, Michiharu; Tamate, Kenichi; Ishikawa, Mutsuo

doi:10.1016/j.mce.2003.12.003

Cited by 15 publications

(9 citation statements)

References 29 publications

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“…It has been shown in rats that HB-EGF is expressed in most granulosa cells of early follicles and all the developing follicles, but not in preovulatory follicles. Furthermore, a strong staining pattern of HB-EGF in corpora lutea was also found in a immunohistochemical study [32]. These results suggest that HB-EGF expression during estrus might be related to the initiation of luteinization.…”

Section: Expression Of the Mrna Of The Egf Superfamily Of Genes As Wsupporting

confidence: 66%

Expression Patterns of the Implantation-associated Genes in the Uterus during the Estrous Cycle in Mice

Lee

Ueta

Xuan

et al. 2005

Journal of Reproduction and Development

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Abstract. The mRNA expression patterns of EGF, HB-EGF, Amphiregulin, EGF receptor, IGF-1, CSF-1, IL-1 alpha, IL-1 beta, IL-1 receptor type 1, IL-1 receptor antagonist, LIF, COX-1, COX-2, Mucin-1, calcitonin, and rat USAG-1 mouse homologue, all of which are involved in the process of conceptus implantation to the endometrium, were examined during the estrous cycle by means of real-time quantitative PCR. COX-2, HB-EGF, LIF, Mucin-1, CSF-1, IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist were temporally regulated during the estrous cycle and highly expressed during the estrous stage. In the case of COX-1, EGF, IGF-1, and EGF receptor, the highest mRNA expression was during the diestrous stage. In contrast, the rat USAG-1 mouse homologue mRNA expression did not change during the estrous cycle. These results indicate that rat USAG-1 mouse homologue expression at implantation might be specifically regulated by embryonic factors rather than the maternal environment.

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Section: Expression Of the Mrna Of The Egf Superfamily Of Genes As Wsupporting

confidence: 66%

Expression Patterns of the Implantation-associated Genes in the Uterus during the Estrous Cycle in Mice

Lee

Ueta

Xuan

et al. 2005

Journal of Reproduction and Development

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“…Interestingly, Conti et al (45) showed that HBEGF levels in the preovulatory follicle were reduced, and this reduction was critical for ovulation. Intriguingly, previous studies showed that down-regulation of HBEGF expression was necessary for the final maturation of follicles (52,53). Therefore, YAP1 activity is associated with HBEGF expression and function during follicle development and ovulation.…”

Section: Discussionmentioning

confidence: 91%

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Huang

et al. 2019

FASEB j.

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Although the role of the Hippo signaling pathway in development and tumorigenesis has been extensively studied in multiple organs, its role in ovarian follicle development remains largely unknown. Here, we report that Yes‐Associated Protein 1 (YAP1), the major effector of Hippo signaling, is spatiotemporally expressed in ovarian granulosa cells and plays a critical role in the regulation of follicle development. We found that the active form of YAP1 (nuclear YAP1) was predominantly expressed in proliferative granulosa cells, whereas the inactive form of YAP1 (cytoplasmic YAP1) was mainly detected in luteal cells (terminally differentiated granulosa cells). Pharmacological inhibition of YAP1 activity disrupted mouse ovarian follicle development in vitro and in vivo. Foxl2 promoter–driven knockout of Yap1 in ovarian granulosa cells resulted in increased apoptosis of granulosa cells, decreased number of corpora lutea, reduced ovarian size, and subfertility in transgenic mice. However, Cyp19a1 promoter–driven knockout of Yap1 in differentiated granulosa cells of preovulatory follicles and luteal cells of corpora lutea had no effect on ovarian morphology and fertility. Mechanistic studies demonstrated that YAP1 interacted with epidermal growth factor receptor and TGF‐β signaling pathways to regulate granulosa cell proliferation, differentiation, and survival. Results from this study identify YAP1 as a critical regulator of granulosa cell proliferation and differentiation. Balanced expression and activation of YAP1 is essential for follicle development and successful reproduction. YAP1 is a promising target for treatment of subfertility associated with abnormal granulosa cell function.—Lv, X., He, C., Huang, C., Wang, H., Hua, G., Wang, Z., Zhou, J., Chen, X., Ma, B., Timm, B. K., Maclin, V., Dong, J., Rueda, B. R., Davis, J. S., Wang, C. Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development. FASEB J. 33, 10049–10064 (2019). http://www.fasebj.org

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“…We have found that in vivo hCG injection or exposure of mouse follicles to LH in vitro produces a rapid increase in mRNAs coding for EREG, AREG, and BTC, three members of the EGF-like growth factor family (62). Conversely, HB-EGF mRNA levels decrease after LH/hCG, suggesting a switch in the pattern of growth factor expression after the LH surge (62,63). Detailed time course studies using microarray analysis indicate that the maximum levels of EREG and AREG mRNAs are attained 2 h after hCG administration in vivo with the mRNAs rapidly declining afterward, therefore preceding COX-2 mRNA maximal expression by 1 h (Fig.…”

Section: Lh Stimulates Egf-like Growth Factor Mrna Expressionmentioning

confidence: 98%

Role of the Epidermal Growth Factor Network in Ovarian Follicles

Conti

Hsieh

Park

et al. 2006

Molecular Endocrinology

327

218

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The LH surge causes major remodeling of the ovarian follicle in preparation for the ovulatory process. These changes include reprogramming of granulosa cells to differentiate into luteal cells, changes in cumulus cell secretory properties, and oocyte maturation. This review summarizes published data in support of the concept that LH stimulation of ovarian follicles involves activation of a local epidermal growth factor (EGF) network. A model describing this property of LH signaling and its branching to other signaling modules is discussed. According to this model, LH activation of mural granulosa cells stimulates cAMP signaling, which, in turn, induces the expression of the EGF-like growth factors epiregulin, amphiregulin, and betacellulin. These growth factors function by activating EGF receptors in either an autocrine/juxtacrine fashion within the mural layer, or they diffuse to act on cumulus cells. Activation of EGF receptor signaling in cumulus cells, together with cAMP priming, triggers oocyte nuclear maturation and acquisition of developmental competence as well as cumulus expansion. This model has important implications for ovarian physiology and for the development of new strategies for the pharmacological control of ovulation and for gamete maturation in vitro.

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Differential expression of heparin-binding epidermal growth factor-like growth factor in the rat ovary

Cited by 15 publications

References 29 publications

Expression Patterns of the Implantation-associated Genes in the Uterus during the Estrous Cycle in Mice

Expression Patterns of the Implantation-associated Genes in the Uterus during the Estrous Cycle in Mice

Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development

Role of the Epidermal Growth Factor Network in Ovarian Follicles

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