Differential Expression of Claudin-1, Claudin-3, and Claudin-4 in Bladder Lesions

Kokenek-Unal, Tuba Dilay; Çoban, İpek; Oguz-Erdogan, Ayse Selcen; Şeneldir, Hatice; Gürçay, Nesrin; Alper, Murat

doi:10.9734/jcti/2015/19336

Cited by 3 publications

(8 citation statements)

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“…However, most of the low-grade tumors were high Claudin-4 expression. Our findings were consistent with those reported by Boireau et al [ 29 ], Kokenek-Unal et al [ 6 ], Saad et al [ 19 ] and Abd El-Fattah et al [ 14 ] as they observed that Claudin-4 expression decreases with increasing histological grade, with a positive significant correlation (P-value= 0.029), (P-value = 0.003), (P-value <0.001) and (P-value 0.006) respectively.…”

Section: Discussionsupporting

confidence: 94%

“…Immunodetection was performed, using a labeled streptavidin-biotin (LSAB) system. A skin section with a histologically normal epidermis was used as a positive control for Claudin-1 and a section from colonic mucosa normal epithelium was used as a positive control for Claudin-4 [ 6 , 19 ]. For negative control of both Claudin-1 and Claudin-4, omitting the primary antibodies was done.…”

Section: Methodsmentioning

confidence: 99%

“…Accordingly, it is evaluated as follows: 0 indicated negative results, 1–2 represented weak expression, 3–6 denoted moderate expression, and 9 meant strong expression. Additionally and weak expressions were classified as low, while moderate and strong were considered as high expressions [ 6 , 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…On the other side, tumors with high histologic grade or muscle-invasive stages have significant mortality rates and are treated totally differently from non-invasive ones. Therefore, there is an emerging need for useful variables to help distinguish muscle-invasive from non-muscle-invasive carcinoma of the urinary bladder [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder

Elsayed,

Mahmoud,

Salem

et al. 2024

Asian Pac J Cancer Prev

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Background: In Egypt, bladder cancer occupies the second rankamong reported cancers in men. Claudins are tight junctions that have a critical role in tumor pathogenesis, invasion, progression, and metastasis and currentlyare a focus of interest for targeting therapies. Objectives: We aimed to evaluatethe immunohistochemical expression of Claudin-1 and Claudin-4 in urinary bladder urothelial carcinoma and investigate the relationshipbetweenthe expressed Claudins with differentclinicopathological parameters. Methods: Claudin-1 and Claudin-4 immunohistochemical expression was studied in 62 cases of urinary bladder urothelial carcinomas. The cases were classified into two categories; low and high Claudin-1 and Claudin-4 expression. Results: High Claudin-1 expression was detected in67.7% of the studied urothelial carcinomas while 32.3% showed low expression. Claudin-1 expression was reduced significantly with high tumor grade, non-papillary tumors, muscle invasion, schistosomal infestation, and perineural invasion (p-value < 0.05). Claudin-4 high expression was detected in 82.3% of our cases while low expression was detected in 17.7%. Claudin-4 reduced expression was significantly associated with non-papillary tumors, muscle invasion, advanced T stages, and associated lympho-vascular emboli (P-value < 0.05). Conclusion: According to the results ofthe present study, the reduced expressions of Claudin-1 and Claudin-4 provide clues concerning the progression of urothelial carcinoma. Consequently, it is thought that Claudin-1 and Claudin-4 could help to differentiatelow-grade from high-grade and muscle-invasive from non-muscle-invasive urothelial carcinomas. In addition, it can be introduced as a possible therapeutic target.

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Section: Discussionsupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder

Elsayed,

Mahmoud,

Salem

et al. 2024

Asian Pac J Cancer Prev

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“…Kokenek-Unal et al reported that most UCs with muscle invasion (80%) presented intense staining, and generally Claudin-1 had significantly lower expression in low-grade UCs compared with high-grade ones [30]. Nakanishi et al observed increases in Claudin-1, -3 and -4 expression in advanced stages of UCs in the upper urinary tract, associated with reduced survival, and in addition, the expression of Claudin-1 and -4 was significantly associated with tumor stage [14].…”

Section: Figure 5 -Distribution Of E-cadherin β-Catenin and Claudin-1...mentioning

confidence: 99%

The role of cell adhesion molecules in the progression of bladder urothelial carcinomas

SĂndulescu

Stepan²,

Mărgăritescu³

et al. 2022

Rom J Morphol Embryol

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Alteration of the intercellular adhesion system plays an essential role in the initiation and progression of bladder carcinomas. We followed the immunoexpression of adhesion molecules, E-cadherin, β-catenin and Claudin-1, in relation to the histopathological grade and the pT category in a number of 50 urothelial carcinomas of the bladder, based on a final staining score (FSS), calculated on the basis of reaction intensity and labeled cells number. E-cadherin immunoexpression was identified in the membrane of tumor cells, low FSS being associated with invasive high-grade carcinomas. β-catenin reactions were membranous in the case of low-grade noninvasive carcinomas and predominantly cytoplasmic and nuclear in the case of high-grade invasive ones, for which high FSS were associated. Claudin-1 was identified at the membrane level, the high FSS values being more frequent in the case of high-grade invasive carcinomas, although there were no significant statistical associations. Loss of E-cadherin expression and the associated positive linear relation of β-catenin and Claudin-1 indicate the usefulness of the analyzed markers in identifying the invasive aggressive phenotype of urothelial bladder carcinomas.

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Significance of silent mating type information regulation 2 homolog 1 and claudin 4 expression in gastric carcinoma and precursor lesions

Emara¹,

Amer²,

Attia³

et al. 2016

Egyptian Journal of Pathology

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Differential Expression of Claudin-1, Claudin-3, and Claudin-4 in Bladder Lesions

Cited by 3 publications

References 0 publications

Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder

Immunohistochemical Expression of Claudin-1 and Claudin-4 in Urothelial Carcinoma of the Urinary Bladder

The role of cell adhesion molecules in the progression of bladder urothelial carcinomas

Significance of silent mating type information regulation 2 homolog 1 and claudin 4 expression in gastric carcinoma and precursor lesions

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