Differential expression of canonical and non‐canonical Wnt ligands in ameloblastoma

Siar, Chong Huat; Nagatsuka, Hitoshi; Han, Phuu Pwint; Buery, Rosario Rivera; Tsujigiwa, Hidetsugu; Nakano, Keisuke; Ng, Kok Han; Kawakami, Toshiyuki

doi:10.1111/j.1600-0714.2011.01104.x

Cited by 42 publications

(53 citation statements)

References 43 publications

(93 reference statements)

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“…Additionally, it has been reported that WNT7A expression is frequently reduced or absent in lung cancers when compared with normal lung and mortal, short-term bronchial epithelial cultures [32]. By Immunohistochemical examination in 72 cases of ameloblastoma, an odontogenic epithelial neoplasm, WNT7A was also found absent [33]. On taking advantage of the free database containing in the cBioPortal for Cancer Genomics, WNT7A mRNA expression (z-score) was also analyzed in the provisional TCAG database from 190 patients with Cervical squamous cell carcinoma (CSCC).…”

Section: Discussionmentioning

confidence: 93%

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Ramos-Solano

Meza-Canales

Torres-Reyes

et al. 2015

Experimental Cell Research

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Section: Discussionmentioning

confidence: 93%

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Ramos-Solano

Meza-Canales

Torres-Reyes

et al. 2015

Experimental Cell Research

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“…Wnt/β‐catenin signalling is involved in ameloblastoma tumorigenesis and progression . Furthermore, it is widely accepted that Wnt/β‐catenin signalling can mediate mechanotransduction in cells .…”

Section: Discussionmentioning

confidence: 99%

“…Wnt/β-catenin signalling is involved in ameloblastoma tumorigenesis and progression. 6 Furthermore, it is widely accepted that Wnt/βcatenin signalling can mediate mechanotransduction in cells. 9 An immunofluorescence assay showed MMP-2, MMP-9 and RANKL were expressed in hTERT + -AM cells, which presented punctate cytoplasmic staining.…”

Section: Discussionmentioning

confidence: 99%

Elevated hydrostatic pressure promotes ameloblastoma cell invasion through upregulation of MMP‐2 and MMP‐9 expression via Wnt/β‐catenin signalling

Yang

Liang

et al. 2018

J Oral Pathology Medicine

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This study indicates that elevated hydrostatic pressure promotes the migration and invasion of ameloblastoma cells by activating the Wnt/β-catenin pathway, thereby increasing expression of MMP-2, MMP-9 and other Wnt signalling downstream targets. This suggests that marsupialization may reduce invasiveness and reverse the bone resorption process by lowering intracystic hydrostatic pressure in cystic ameloblastoma.

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“…Consequently, the ghost cells showed strong positive reaction to antibodies against hair proteins. Moreover, Wnt signaling is believed to be responsible for the increase β-catenin expression in the cytoplasm and nucleus of epithelial cells in close proximity as well as the nuclear localization of Lef-1 13.…”

Section: Discussionmentioning

confidence: 99%

Wnt Signaling as a Possible Promoting Factor of Cell Differentiation in Pleomorphic Adenomas

et al. 2014

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There are well known that Wnt signaling was some roles of cell differentiation at the development tissues, especially the oral and maxillofacial regions of some developmental stages. Therefore, to determine Wnt signaling in the pleomorphic adenoma tissues, we examined. The expression of Wnt1 and β-catenin as well as the distribution of various cytoskeletal proteins CK7 and CK13 was examined in 30 cases of pleomorphic adenoma by immunohistochemistry. Wnt1 was detected in almost all tumor cells. The peripheral columnar cells in squamous metaplasia and small cuboidal cells in duct-like structures were strongly positive to Wnt1. Although β-catenin was clearly localized on the cell membrane of tumor cells, nuclear translocation was observed in small cuboidal cells and in some basaloid cells. The immunofluorescent staining pattern of Wnt1 and CK7 as well as Wnt1 and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt is involved in tumor cell differentiation of peripheral columnar cells forming solid nests and small peripheral columnar cells forming duct-like structures. Moreover, among the three currently known Wnt pathways, β-catenin is the suggested pathway working during cell differentiation. Furthermore, peripheral columnar cells in solid tumor nests and in squamous metaplasia are governed by another Wnt pathway other than β-catenin. Therefore, Wnt signaling through β-catenin pathway may be involved in the 'mixed' differentiation characteristic of pleomorphic adenoma although another pathway may also be possibly working in other parts of the tumor tissue.

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Differential expression of canonical and non‐canonical Wnt ligands in ameloblastoma

Cited by 42 publications

References 43 publications

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration

Elevated hydrostatic pressure promotes ameloblastoma cell invasion through upregulation of MMP‐2 and MMP‐9 expression via Wnt/β‐catenin signalling

Wnt Signaling as a Possible Promoting Factor of Cell Differentiation in Pleomorphic Adenomas

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