Differential expression analysis identifies candidate synaptogenic molecules for wiring direction-selective circuits in the retina
J. Tworig,
R. Morrie,
K. Bistrong
et al.
Abstract:An organizational feature of neural circuits is the specificity of synaptic connections. A striking example is the direction-selective (DS) circuit of the retina. There are multiple subtypes of DS retinal ganglion cells (DSGCs) that prefer motion along one of 4 preferred directions. This computation is mediated by selective wiring of a single inhibitory interneuron, the starburst amacrine cell (SAC), with each DSGC subtype preferentially receiving input from a subset of SAC processes. We hypothesize that the m… Show more
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