Differential Effects of Photoaging vs Intrinsic Aging on the Vascularization of Human Skin

Decline of lymphatic vessel density and function in murine skin during aging

“…Using whole mount stainings of ears for the lymphatic marker LYVE-1 to assess the density and morphology of initial lymphatic vessels, we found a significant reduction in lymphatic density in the skin of aged mice compared to young controls. These changes are similar to those reported in blood vessels and lymphatic vessels in the photoaged skin of humans [29,30]. While there was no difference in the diameter of the initial lymphatic vessels, a reduction of branching points was found in aged mice, indicating a reduced complexity of the network.…”

Changes in Human Skin Composition Due to Intrinsic Aging: A Histologic and Morphometric Study

“…These results are in line with a previous study demonstrating that a decrease in dermal vascular density is related to downregulation of the vascular endothelial growth factor signaling cascade and lower levels of Von Willebrand Factor (Gunin et al, 2014). Despite several studies agree on the reduction of cutaneous blood ow (Waller and Maibach, 2005), this nding is a bit controversial as other studies support just the opposite (Chung et al, 2002). Nonetheless, this reduction could explain numerous skin changes attributed to intrinsic aging; being partly a cause and consequence of atrophy, for example, of the annexes.…”

Diameter-dependent classification of dermal vasculature using optical coherence tomography angiography

“…Regarding photoaging alteration, this study shows that the VVD in the cheek area decreased with age. A similar aging trend was observed in the histological section images ( 37 ) and the MIP images of OCTA ( 16 ). As the VVD retains non-invasive 3D information, it represents a more accurate vessel structure of the organism.…”