Differential Effects of Oral Estrogen Versus Oral Estrogen-Androgen Replacement Therapy on Body Composition in Postmenopausal Women

Dobs, Adrian S.; Nguyen, T. T. T.; Pace, Cindy; Roberts, Carla P.

doi:10.1097/00006254-200209000-00019

Cited by 16 publications

(37 citation statements)

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“…However, in healthy women, no β‐cell dysfunction is observed as a consequence of excessive androgens stimulation . Androgens administration in women seem not dangerous, and favourable effects on body composition have been reported , suggesting that an androgen therapy can be safely used also in women.…”

Section: Androgens and Type‐2 Diabetesmentioning

confidence: 99%

Testosterone a key factor in gender related metabolic syndrome

Bianchi

Locatelli

2018

Obesity Reviews

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Metabolic syndrome (MetS) is highly correlated with cardiovascular diseases. Although an excess of body fat is a determinant factor for MetS development, a reduced level of testosterone plays a fundamental role in its regulation. Low testosterone level is highly related to insulin resistance, visceral obesity and MetS. We have searched in Pubmed clinical trial with the password: testosterone and insulin resistance, and testosterone and MetS. We found 19 studies on the correlation between testosterone level with insulin resistance and 18 on the effect of testosterone therapy on MetS. A high correlation between low testosterone and insulin resistance has been found in men, but not in women. Testosterone administration in hypogonadal men improved MetS and reduced the mortality risk. Androgen and oestrogen receptors are expressed in adipocytes, muscle and liver tissue, and their activation is necessary to improve metabolic control. Normalization of testosterone level should be the primary treatment in men, along with caloric restriction and physical exercise. These findings come mainly from correlative data, and there remains a need for randomized trials to strengthen this evidence. This review will consider the effects of testosterone on the regulation and development of MetS in men and women.

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Section: Androgens and Type‐2 Diabetesmentioning

confidence: 99%

Testosterone a key factor in gender related metabolic syndrome

Bianchi

Locatelli

2018

Obesity Reviews

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“…Topically applied androgen is capable of reducing total body weight and abdominal fat accumulation in postmenopausal women [Gruber et al, 1998]. Women treated with androgen and estrogen co‐therapy, compared with estrogen treatment alone, showed increased total lean body mass and a reduction in the percentage fat for all tissues examined [Dobs et al, 2002; Floter et al, 2005]. Furthermore, low‐dose treatment improves functional capacity, insulin resistance, and muscle strength in women (as in men) with chronic heart failure [Iellamo et al, 2010].…”

Section: Discussionmentioning

confidence: 99%

Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes

Wiren¹,

Hashimoto

Zhang

2011

J. Cell. Biochem.

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Detrimental changes in body composition are often associated with declining levels of testosterone. Here we evaluated the notion that multipotent mesenchymal stem cells (MSC), that give rise to both fat and muscle tissue, can play a significant role to alter existing body composition in the adult. Transgenic mice with targeted androgen receptor (AR) overexpression in stem cells were employed. Wild-type littermate and AR-transgenic male and female mice were gonadectomized and left untreated for 2 months. After the hypogonadal period, mice were then treated with 5α-dihydrotestosterone (DHT) for 6 weeks. After orchidectomy (ORX), wild-type males have reduced lean mass and increased fat mass compared to shams. DHT treatment was beneficial to partially restore body composition. In wild-type females, ovariectomy (OVX) produced a similar change but there was no improvement with DHT. In targeted AR transgenic mice, DHT treatment increased lean and reduced fat mass to sham levels. In contrast to wild-type females, DHT treatment in female transgenic mice significantly ameliorated the increased fat and decreased lean mass changes that result after OVX. Our results indicate that DHT administration reduces fat mass and increases lean mass in wild-type males but not females, indicating that wild-type females are not as sensitive to androgen treatment. Because both male and female transgenic mice are more responsive than wild-type, results suggest that body composition remains linked to stem cell fate in the adult and that targeted androgen signaling in stem cells can play a significant role to reverse detrimental changes in body composition in both sexes.

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“…Dose‐dependent improvements in several domains of sexual function, lean body mass, chest‐press power and loaded stair‐climb power were observed, with the greatest improvements at the highest dose. Furthermore, a double‐blind randomized study by Dobs and colleagues, with 40 naturally and surgically menopausal women, observed significant increases in upper and lower body strength with testosterone compared to placebo . Whilst the majority of studies observed testosterone significantly increased sexual arousal/interest, frequency of orgasms and frequency of sexual activity when compared to placebo, some suggest no significant difference between the treatment groups .…”

Section: Effects Of Testosterone Supplementation On Sexual Functionmentioning

confidence: 99%

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

Jayasena

Alkaabi

Liebers

et al. 2019

Clinical Endocrinology

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Summary The clinical sequelae of oestrogen deficiency during menopause are undoubted. However, the pathophysiological role of testosterone during the menopause is less clear. Several randomized, placebo‐controlled clinical trials suggest that testosterone therapy improves sexual function in postmenopausal women. Some studies suggest that testosterone therapy has additional effects, which include increased bone mineral density and decreased serum high‐density lipoprotein (HDL) cholesterol. Furthermore, the long‐term safety profile of testosterone therapy in postmenopausal women is not clear. This article will provide a concise and critical summary of the literature, to guide clinicians treating postmenopausal women.

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Differential Effects of Oral Estrogen Versus Oral Estrogen-Androgen Replacement Therapy on Body Composition in Postmenopausal Women

Cited by 16 publications

References 0 publications

Testosterone a key factor in gender related metabolic syndrome

Testosterone a key factor in gender related metabolic syndrome

Stem cell activation in adults can reverse detrimental changes in body composition to reduce fat and increase lean mass in both sexes

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

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