Differential effects of nandrolone decanoate in fast and slow rat skeletal muscles

Joumaa, Wissam H.; Léoty, Claude

doi:10.1097/00005768-200103000-00011

Cited by 24 publications

(39 citation statements)

References 28 publications

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“…This section of our finding is accordance with those of Lindqvist and Fahlke which reported that ND-treated rats water consumption was significantly higher than those of control group [20]. Higher food and water intake in test groups may be due to ND cause alter metabolism in skeletal muscle and alteration in the excitation-contraction coupling mechanism [21]. Lindblom et al reported that ND treatment affected on proopiomelanocorthin (POMC) production and affected food intake in rats [22].…”

Section: Discussionsupporting

confidence: 91%

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Shahraki

Rafeei

2015

Zahedan J Res Med Sci

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Background: Nandrolone decanoate (ND) is a doping agent which is used by athletes and has a lot of adverse effects on the body. Objectives: This survey was carried out to evaluate the effects of subacute supraphysiological dose of ND administration on liver enzymes and lipid profiles in male and female rats. Materials and Methods: This experimental study was performed on 40 Wistar-Albino rats, which after weighing divided into 4 groups as control (female and male) and test (female and male) groups (N = 10). The test groups received 15 mg/kg nandrolone decanoate by intra muscular (im) injection for 2 weeks, but control groups received the same volum of oil vehicle. At the end, animals were deeply anesthetized by diethyl ether, scarified and their blood samples were collected. Liver enzymes and lipoproteins were measured by usual methods. Obtained data were analyzed by SPSS-15, applying ANOVA and Tukey tests. Results were expressed as mean ± SD. Statistical difference was recognized significant by P ≤ 0.05. Results: Results showed that AST value in the test groups were significantly increased compared to those of the control groups. In addition, HDL and cholesterol values in female test group were significantly increased compared to those of male test group. Moreover, final weight, food, and water intake in all test groups were significantly increased compared to those of control groups. Conclusions: These results indicated that subacute administration of nandrolone decanoate alters liver enzymes, lipoprotein profile, final weight, food, and water intake in rats. The exact mechanism needs future studies.

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Section: Discussionsupporting

confidence: 91%

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Shahraki

Rafeei

2015

Zahedan J Res Med Sci

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“…This chamber, with an open-topped channel 1.3 ϫ 1.3 ϫ 25.0 mm, has at one end a four-way tap that opens directly into the channel, allowing rapid change of the perfusion solution (Ͻ0.2 s), or into a drain so that perfusion by stagnant solutions is avoided. The preparation was mounted as described by Joumaa and Léoty (2001). Briefly, one tendon of the preparation was snared under a fine silver loop and fixed in the open-topped channel.…”

Section: Methodsmentioning

confidence: 99%

Methyl Jasmonate-Induced Stimulation of Sarcoplasmic Reticulum Ca²⁺-ATPase Affects Contractile Responses in Rat Slow-Twitch Skeletal Muscle

Joumaa

Bouhlel²,

Même³

et al. 2002

J Pharmacol Exp Ther

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The purpose of this study was to determine whether methyl jasmonate, a stimulator of Ca 2ϩ -adenosine triphosphatase (ATPase) activity of the purified ATPase from fast-twitch skeletal muscle, could affect contractile responses in small bundles of rat isolated slow-twitch (soleus) fibers. In saponin-skinned fibers, sarcoplasmic reticulum (SR) Ca 2ϩ loading was performed in pCa 7.0 solution. The amount of Ca 2ϩ taken up was monitored by use of the amplitude of contraction following application of 10 mM caffeine. Results indicate that the increased loading rate in the presence of methyl jasmonate is likely due to stimulation of the SR Ca 2ϩ -ATPase. In Triton-skinned fibers, the myofibrillar Ca 2ϩ sensitivity was not changed by methyl jasmonate (50 -200 M). In intact fibers, the amplitude and the time constant of relaxation of twitch and potassium contracture were reversibly reduced after 2 min of application of methyl jasmonate at a concentration of up to 125 M. At higher concentrations (Ͼ150 M), effects were not reversible. In the presence of methyl jasmonate (100 M), the relationship between the amplitude of potassium contractures and the membrane potential shifted to more positive potentials, whereas the steady-state inactivation curve was unchanged. These observations suggest that methyl jasmonate has no effect on voltage sensors. Taken together, our results show that methyl jasmonate is a potent, reversible, and specific stimulator of the SR Ca 2ϩ pump in slow-twitch skeletal muscle and is an extremely valuable pharmacological tool for improving relaxation and studying calcium-signaling questions.

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“…AAS cause both the increased synthesis and decreased catabolism of muscle proteins [34]. They trigger muscle hypertrophy and protein synthesis, resulting in greater muscle mass and strength, and reduce recovery time by blocking the catabolic effects of cortisol [4,5,[47][48][49]. As a result, AAS are useful in treating chronic wasting conditions such as cancer and AIDS [50,51].…”

Section: Therapeutic Use Of Aasmentioning

confidence: 99%

Anabolic androgenic steroids effects on the immune system: a review

et al. 2009

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Androgenic anabolic steroids (AAS) are synthetic derivatives of the male hormone testosterone. AAS are used by athletes and recreational users of all ages to enhance their athletic performance and/or physical appearance. While several adverse effects of AAS abuse have been described, their effect on the immune system has not been clearly elucidated. The literature generally indicates that supraphysiologic doses of AAS with an intact steroid nucleus are immunosuppressive, that is they reduce immune cell number and function. While those with alterations to the steroid nucleus are immunostimulatory as they induce the proliferation of T cells and other immune cells. Specifically, several common AAS have been shown to adversely influence lymphocyte differentiation and proliferation, antibody production, Natural Killer Cytotoxic activity and the production of certain cytokines, thereby altering the immune reaction. These effects may be profound and long lasting depending on the dosing regime, types or combinations of AAS used and the extent and duration of AAS abuse. Nevertheless, the effects of long term use of supraphysiologic doses of AAS on the immune system remain uncertain.

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Differential effects of nandrolone decanoate in fast and slow rat skeletal muscles

Cited by 24 publications

References 28 publications

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Methyl Jasmonate-Induced Stimulation of Sarcoplasmic Reticulum Ca²⁺-ATPase Affects Contractile Responses in Rat Slow-Twitch Skeletal Muscle

Anabolic androgenic steroids effects on the immune system: a review

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Differential effects of nandrolone decanoate in fast and slow rat skeletal muscles

Cited by 24 publications

References 28 publications

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

The Effects of Subacute Supraphysiological Dose of Nandrolone Decanoate on Liver Enzymes and Lipid Pofiles in Rats

Methyl Jasmonate-Induced Stimulation of Sarcoplasmic Reticulum Ca2+-ATPase Affects Contractile Responses in Rat Slow-Twitch Skeletal Muscle

Anabolic androgenic steroids effects on the immune system: a review

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Methyl Jasmonate-Induced Stimulation of Sarcoplasmic Reticulum Ca²⁺-ATPase Affects Contractile Responses in Rat Slow-Twitch Skeletal Muscle