volume 93, issue 0, P3-P-288 2020
DOI: 10.1254/jpssuppl.93.0_3-p-288
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Rei Yokoyama,
Yukio Ago,
Momoko Higuchi
et al.

Abstract: Clinical and preclinical studies have shown that the NMDA receptor antagonist ketamine exerts rapid and longlasting antidepressant effects. Although ketamine metabolites might also have potential antidepressant properties, controversial results have been reported on (2R,6R)-hydroxynorketamine ((2R,6R)-HNK) in particular and there is little information on the effects of other ketamine metabolites. Here we aimed to compare the effects of (R)norketamine ((R)-NK), (S)-NK, (2R,6R)-HNK and (2S,6S)-HNK in a mouse mod…

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