2009
DOI: 10.1097/aln.0b013e3181ba3c11 View full text |Buy / Rent full text
|
|

Abstract: Both hypercapnic acidosis and buffered hypercapnia attenuate the hemodynamic consequences of systemic sepsis. In contrast, hypercapnic acidosis, but not buffered hypercapnia, reduced the severity of sepsis-induced lung injury.

Help me understand this report

Search citation statements

Order By: Relevance
Select...
2
1
1
1
0
38
1
1

Year Published

2011
2011
2015
2015

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

0
38
1
1
Order By: Relevance
“…Acute hypercapnic acidosis has been suggested to attenuate lung injury in ischemic reperfusion (Laffey et al, 2000a), sepsis Higgins et al, 2009), and endotoxin (Norozian et al, 2011) models, raising the possibility of a potential therapeutic application of hypercapnia in acute lung injury (ALI) (therapeutic hypercapnia).…”
Section: Introductionmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Acute hypercapnic acidosis has been suggested to attenuate lung injury in ischemic reperfusion (Laffey et al, 2000a), sepsis Higgins et al, 2009), and endotoxin (Norozian et al, 2011) models, raising the possibility of a potential therapeutic application of hypercapnia in acute lung injury (ALI) (therapeutic hypercapnia).…”
Section: Introductionmentioning
“…A tracheostomy was performed, and static lung compliance assessment and arterial blood gas analysis performed as previously described. 21,22 After 20 min, Fi O2 was increased to 1.0 for 15 min, and arterial PO 2 measured. After heparin (400 U·kg −1 ; CP Pharmaceuticals, Wrexham, United Kingdom) administration, animals were euthanized by exsanguination under anesthesia.…”
Section: Lung Injury and Repair Assessmentmentioning
“…Both buff ered hypercapnia and hypercapnic acidosis reduced the severity of early shock and attenuated the increase in serum lactate compared with normocapnia. In contrast, buff ered hypercapnia did not attenuate physiologic or histologic indices of lung injury in these studies [45]. Reassuringly, there was no evidence to suggest that buff ered hypercapnia worsened the degree of lung injury compared to normocapnia, and buff ered hypercapnia did not increase the bacterial load in the lungs or the bloodstream [45].…”
Section: Systemic Sepsismentioning
“…In a study designed to assess the contribution of acidosis versus hypercapnia to the eff ects of hypercapnic acidosis on the lung and hemodynamic profi le in systemic sepsis, Higgins et al exposed rats to environmental hypercapnia until renal buff ering had restored pH to the normal range [45]. Both buff ered hypercapnia and hypercapnic acidosis reduced the severity of early shock and attenuated the increase in serum lactate compared with normocapnia.…”
Section: Systemic Sepsismentioning