Differential effect of baclofen on cortical and spinal inhibitory circuits

̌Sťetkářová, Ivana; Kofler, Markus

doi:10.1016/j.clinph.2012.07.005

Cited by 70 publications

(48 citation statements)

References 72 publications

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“…One longitudinal study in a patient with generalized dystonia demonstrated CSP lengthening at high doses (P1.000 lg/d) of intrathecal baclofen (Siebner et al, 1998). This was recently confirmed in patients with spinal cord injury or progressive multiple sclerosis in whom an intrathecal bolus application of baclofen lengthened the CSP but not the cutaneous silent period, an inhibition selectively mediated by spinal circuits (Stetkarova and Kofler, 2013).…”

Section: Cortical Silent Period (Csp) Durationmentioning

confidence: 93%

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TMS and drugs revisited 2014

Ziemann

Reis

Schwenkreis

et al. 2015

Clinical Neurophysiology

558

583

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Section: Cortical Silent Period (Csp) Durationmentioning

confidence: 93%

“…[9] (Stetkarova and Kofler, 2013); [10] (Werhahn et al, 1999); [11] (Pierantozzi et al, 2004); [12] (Inghilleri et al, 1996); [13] ; [14] (Priori et al, 1994). (C) Short-interval intracortical inhibition (SICI).…”

Section: Mg C Short-interval Intracortical Inhibitionmentioning

confidence: 99%

TMS and drugs revisited 2014

Ziemann

Reis

Schwenkreis

et al. 2015

Clinical Neurophysiology

558

583

View full text Add to dashboard Cite

“…Baclofen is known to act at the spinal, brainstem and cortical level. [41][42][43] Nevertheless, all the selected patients were taking a similar dose of baclofen, ranging from 25 to 30 mg/day. Thus, the cortical and spinal excitability are likely to be influenced in a similar manner in all subjects by the chronic intake of the antispastic drug.…”

Section: Discussionmentioning

confidence: 99%

Assessment of corticospinal excitability after traumatic spinal cord injury using MEP recruitment curves: a preliminary TMS study

et al. 2015

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Study design: Transcranial magnetic stimulation study. Objectives: To further investigate the corticospinal excitability changes after spinal cord injury (SCI), as assessed by means of transcranial magnetic stimulation (TMS). Setting: Merano (Italy) and Salzburg (Austria). Methods: We studied resting motor threshold (RMT), motor evoked potential (MEP) amplitude and recruitment curve in five subjects with good recovery after traumatic incomplete cervical SCI. Results: RMT did not differ significantly between patients and controls, whereas the slope of MEP recruitment curve was significantly increased in the patients. Conclusion: This abnormal finding may represent an adaptive response after SCI. The impaired ability of the motor cortex to generate proper voluntary movement may be compensated by increasing spinal excitability. The easily performed measurement of MEP recruitment curve may provide a useful additional tool to improve the assessment and monitoring of motor cortical function in subjects with SCI. Increasing our knowledge of the corticospinal excitability changes in the functional recovery after SCI may also support the development of effective therapeutic strategies.

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“…40 ), or GABA B agonists (baclofen) (ref. 38,41,42 ). Recently, increased CSP duration following tramadol application has been attributed to its monoaminergic action leading to inhibition of serotonin and noradrenaline reuptake 43 .…”

Section: Msa Patientmentioning

confidence: 99%

Cutaneous silent periods in multiple system atrophy

̌Sťetkářová¹,

Kofler²,

Majerová³

2015

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Aim. The cutaneous silent period (CSP) is a spinal inhibitory reflex primarily mediated by A-delta fibers. Prolonged CSPs have been reported in patients with restless legs syndrome (RLS) and idiopathic Parkinson's disease (IPD). Dopaminergic medication normalizes the CSP, concurring with the effect of levodopa on CSPs. To date, CSPs have not been extensively studied in patients with multiple system atrophy (MSA). The purpose of this study was to confirm abnormal CSP findings in a group of MSA patients and to affirm the lack of influence of levodopa on CSPs during long-term treatment. Methods. We investigated 15 patients (4 males, 11 females, age 58-71 years) who fulfilled the diagnostic criteria for possible MSA. Thirteen patients had predominant parkinsonian symptoms (MSA-P), 2 had predominant cerebellar signs (MSA-C). We recorded CSPs in thenar muscles following noxious digit II stimulation. Sixteen healthy volunteers (6 males, 10 females, range 24-56 years) served as control subjects for CSP recordings. Results. Group average CSP onset was mildly delayed (P<0.01), whereas CSP end latency (P<0.001) were markedly delayed and CSP duration prolonged (P<0.001) in MSA patients compared to healthy controls. MSA patients on levodopa treatment did not differ in their CSPs from those without levodopa. The dose of levodopa did not correlate to any CSP parameter. Conclusion. The observed CSP prolongation corroborates previous findings in a limited number of MSA patients. The ineffectiveness of long-term levodopa on CSP abnormalities is consistent with its poor clinical effect in MSA.

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Differential effect of baclofen on cortical and spinal inhibitory circuits

Cited by 70 publications

References 72 publications

TMS and drugs revisited 2014

TMS and drugs revisited 2014

Assessment of corticospinal excitability after traumatic spinal cord injury using MEP recruitment curves: a preliminary TMS study

Cutaneous silent periods in multiple system atrophy

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