Differential effect of anterior cingulate cortex lesion on mechanical hypersensitivity and escape/avoidance behavior in an animal model of neuropathic pain

LaGraize, Stacey C.; LaBuda, Christopher J.; Rutledge, Margaret A.; Jackson, Raymond L.; Fuchs, Perry N.

doi:10.1016/j.expneurol.2004.04.003

Cited by 145 publications

(96 citation statements)

References 56 publications

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“…In patients with epilepsy undergoing stereoencephalographic mapping, painful somatic sensations have been reported during electrical stimulation of the insula [25,26] . ACC lesions selectively reduce the affective component of neuropathic pain [27] , whereas ACC stimulation in rodents inhibits mechanical allodynia [28] . In addition to affective and emotional components of pain, the ACC has also been suggested to induce analgesia through its influence over descending PAG and spinal cord projections.…”

Section: Discussionmentioning

confidence: 99%

Pain Relief and Functional Recovery in Patients with Complex Regional Pain Syndrome after Motor Cortex Stimulation

Fonoff

Hamani²,

Andrade

et al. 2011

Stereotact Funct Neurosurg

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In addition to pain and neurovegetative symptoms, patients with severe forms of complex regional pain syndrome (CRPS) develop a broad range of symptoms, including sensory disturbances, motor impairment and dystonic posturing. While most patients respond to medical therapy, some are considered refractory and become surgical candidates. To date, the most commonly used surgical procedure for CRPS has been spinal cord stimulation. This therapy often leads to important analgesic effects, but no sensory or motor improvements. We report on 2 patients with pain related to CRPS and severe functional deficits treated with motor cortex stimulation (MCS) who not only had significant analgesic effects, but also improvements in sensory and motor symptoms. In the long term (27 and 36 months after surgery), visual analog scale pain scores were improved by 60–70% as compared to baseline. There was also a significant increase in the range of motion in the joints of the affected limbs and an improvement in allodynia, hyperpathia and hypoesthesia. Positron emission tomography scan in both subjects revealed that MCS influenced regions involved in the circuitry of pain.

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Section: Discussionmentioning

confidence: 99%

Pain Relief and Functional Recovery in Patients with Complex Regional Pain Syndrome after Motor Cortex Stimulation

Fonoff

Hamani²,

Andrade

et al. 2011

Stereotact Funct Neurosurg

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show abstract

“…Previous studies have suggested that common biological pathways and neurotransmitters including serotonin and norepinephrine may be involved in the mechanisms of pain and depression (Schatzberg, 2004;Fishbain,1997) and that certain brain regions such as the anterior cingular cortex (ACC) play a critical role in the integration of mood and nociception (Johansen et al, 2001;Gao et al, 2004;Stacey C. LaGraize, et al, 2004;Frankland and Teixeira, 2005). In addition, melatonin (5-methoxy-N-acetyltryptamine), a pineal neurohormone and a derivative of serotonin, may be critically involved in the regulation of both mood and pain (Sugden, 1983;El-Shenawy et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Exacerbated mechanical allodynia in rats with depression-like behavior

et al. 2008

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Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depressionlike behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melotoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression.

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“…Moreover, ACC lesions attenuated pain avoidance to electrical stimulation in macaque monkeys [53]. Interestingly, ACC lesions were not shown to affect pain hypersensitivities in animal models of neuropathic pain [48,51,54], but did reduce escape/avoidance behavior Fig. 1 Cartoon of sagittal brain sections illustrating the networks involved in pain and addiction.…”

Section: What Can We Learn From Operant and Behavioral Paradigms Typimentioning

confidence: 99%

“…Note that many brain structures of the sensory and affective pain circuitry overlap with reward/ aversion circuitry implicated in addiction. ACC (anterior cingulate cortex), AMY (amygdala), CC (corpus collosum), DS (dorsal striatum), HYP (hypothalamus), NAc (nucleus accumbens), OFC (orbitofrontal cortex), PAG (periaqueductal grey), PB (parabrachial nucleus), PFC (prefrontal cortex), S1 (primary somatosensory cortex), S2 (secondary somatosensory cortex), VTA (ventral tegmental area) induced by mechanical stimulation of the hindpaw ipsilateral to nerve injury [54]. In an animal model of migraine pain, intracerebral injection of lidocaine into the rostral ventral medulla produced a CPP that was significantly attenuated by lesions of the rostral ACC [38•], demonstrating that this brain structure may also be important in the aversive component of migraine pain.…”

Section: What Can We Learn From Operant and Behavioral Paradigms Typimentioning

confidence: 99%

Migraine and Reward System—Or Is It Aversive?

Cahill¹,

Cook

Pickens

2014

Curr Pain Headache Rep

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Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain regions within pain and reward circuitry that contribute to negative affect and subjective experience of pain. The emotional component of pain has been argued to be a greater metric of quality of life than its sensory component, and thus understanding the processes that influence this pain characteristic is essential to developing novel treatment strategies for mitigating migraine pain. We emphasize and provide evidence that abnormalities within the mesolimbic cortical reward pathways contribute to migraine pain and that there are structural and functional neuroplasticity within the overlapping brain regions common to both pain and reward.

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Differential effect of anterior cingulate cortex lesion on mechanical hypersensitivity and escape/avoidance behavior in an animal model of neuropathic pain

Cited by 145 publications

References 56 publications

Pain Relief and Functional Recovery in Patients with Complex Regional Pain Syndrome after Motor Cortex Stimulation

Pain Relief and Functional Recovery in Patients with Complex Regional Pain Syndrome after Motor Cortex Stimulation

Exacerbated mechanical allodynia in rats with depression-like behavior

Migraine and Reward System—Or Is It Aversive?

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