Differential down-regulation of delta opioid binding sites during physical dependence on methionine enkephalin in the rat

Steece, Kathy A.; Lee, John M.; Fields, Jeremy Z.; DeLeon-Jones, Frank A.; Ritzmann, Ronald F.

doi:10.1016/0024-3205(89)90323-8

Cited by 11 publications

(3 citation statements)

References 22 publications

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“…3 Further studies are necessary to elucidate if the smaller increases of opioid receptor binding in PHC represent an intrinsic characteristic of the patients susceptible to present anticonvulsant effects induced by HFS, or it is a consequence of the repetitive exposure to the endogenous opioids released by HFS. 28,29 In addition, the lower susceptibility to the HFS-induced antiepileptic effects of patients with higher opioid receptor binding in PHC (ESWAE group) supports the notion that the activation of mu, delta and nociceptin opioid receptors facilitates the seizure activity. [8][9][10][30][31][32][33][34] The enhanced activation or release of inhibitory neurotransmitters such as GABA has been proposed as a mechanism of HFS to induce inhibitory effects.…”

Section: Discussionmentioning

confidence: 87%

Opioid receptor binding in parahippocampus of patients with temporal lobe epilepsy: Its association with the antiepileptic effects of subacute electrical stimulation

Rocha¹,

Cuéllar-Herrera²,

Velasco³

et al. 2007

Seizure

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Opioid receptor binding was evaluated in parahippocampal cortex (PHC) obtained from patients with intractable mesial temporal lobe epilepsy (MTLE) with and without subacute high frequency electrical stimulation (HFS) in this brain area. Mu, delta and nociceptin receptor binding was determined by autoradiography in PHC of five patients (ESAE group) with MTLE history of 14.8 +/- 2.5 years and seizure frequency of 11 +/- 2.9 per month, two of them (40%) with mesial sclerosis. This group demonstrated antiepileptic effects following subacute HFS (130 Hz, 450 micros, 200-400 microA), applied continuously during 16-20 days in PHC. Values were compared with those obtained from patients with severe MTLE (history of 21.7 +/- 2.8 years and seizure frequency of 28.2 +/- 14 per month) in whom electrical stimulation did not induce antiepileptic effects (ESWAE group, n = 4), patients with MTLE in whom no electrical stimulation was applied (MTLE group, n = 4) and autopsy material acquired from subjects without epilepsy (n = 4 obtained from three subjects). Enhanced 3H-DAMGO (MTLE, 755%; ESAE, 375%; ESWAE, 693%), 3H-DPDPE (MTLE, 242%; ESAE, 80%; ESWAE, 346%) and 3H-nociceptin (MTLE, 424%; ESAE, 217%; ESWAE, 451%) binding was detected in the PHC of all epileptic groups. However, tissue obtained from ESAE group demonstrated lower opioid receptor binding (3H-DAMGO, 44.5%, p < 0.05; 3H-DPDPE, 47%, p < 0.05; 3H-nociceptin, 39.3%, p < 0.5) when compared with MTLE group. The present results indicate that a high effectiveness to the antiepileptic effects induced by HFS is associated with reduced opioid peptide binding.

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Section: Discussionmentioning

confidence: 87%

Opioid receptor binding in parahippocampus of patients with temporal lobe epilepsy: Its association with the antiepileptic effects of subacute electrical stimulation

Rocha¹,

Cuéllar-Herrera²,

Velasco³

et al. 2007

Seizure

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“…Since present data showed a decrease in ‰-opioid receptor density in hypothalamic lateral area of offsprings from female rats stressed on days 7-11 of gestation, we suggest that during the embryonal period methionine-enkephalin may mediate downregulation of ‰-opioid receptors as seen in rat brain exposed to exogenous opiates [25,26].…”

Section: Discussionmentioning

confidence: 89%

“…In addition, the administration of etorphine, which has a very high affinity for both Ì-and ‰-opioid receptors, to mature rat, produced a time-dependent decrease in [ 3 H]diprenorphine binding which was due to a downregulation of both Ì-and ‰-opioid receptors [25]. Furthermore, chronic methionine-enkephalin produced a regionally specific downregulation of ‰-opioid receptors [26].…”

Section: Discussionmentioning

confidence: 97%

Autoradiographic Evidence of Delta-Opioid Receptor Downregulation after Prenatal Stress in Offspring Rat Brain

Sánchez

Milanés²,

Pazos³

et al. 2000

Pharmacology

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In order to visualize neuroanatomical alterations in specific brain regions, light microscopy autoradiography was carried out on offsprings (postnatal day 10) from female rats stressed in different periods of gestation and controls. Group 1 was subjected to restraint stress from day 2 to 6; group 2, from day 7 to 11; group 3, from day 12 to 16; group 4 from day 2 to 16. Group 2 showed decreases in δ-opioid receptor density in different hypothalamic regions. The decrease in δ-opioid receptor density was less marked in groups 1 and 3 whereas there was no modification in group 4. Present data suggest that the prenatal stress induces a downregulation of δ-receptors in different hypothalamic regions.

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Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin

Beckman¹,

Llados-Eckman²,

Stanton³

1992

Brain Research

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Differential down-regulation of delta opioid binding sites during physical dependence on methionine enkephalin in the rat

Cited by 11 publications

References 22 publications

Opioid receptor binding in parahippocampus of patients with temporal lobe epilepsy: Its association with the antiepileptic effects of subacute electrical stimulation

Opioid receptor binding in parahippocampus of patients with temporal lobe epilepsy: Its association with the antiepileptic effects of subacute electrical stimulation

Autoradiographic Evidence of Delta-Opioid Receptor Downregulation after Prenatal Stress in Offspring Rat Brain

Reduction of hibernation bout duration by intraventricular infusion of met-enkephalin

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