Differential diagnosis of microcytic anemia: the role of microcytic and hypochromic erythrocytes

Urrechaga, Eloísa; Hoffmann, J. J. M. L.; Edo, Sílvia; Escanero, Jesús F.

doi:10.1111/ijlh.12290

Cited by 28 publications

(26 citation statements)

References 22 publications

(37 reference statements)

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“…Thus, CHr seems to be influenced by haemoglobinisation and especially by the size of RBCs. These results are similar to those reported previously by Vicinanza et al ,7 Chouliaras et al ,13 Urrechaga et al 18 and Ceylan et al 19 using the same analytical platform. However, some of them reported insufficient sensitivity and/or specificity of CHr for discriminating both entities 13 19.…”

Section: Discussionsupporting

confidence: 92%

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Reticulocyte parameters of delta beta thalassaemia trait, beta thalassaemia trait and iron deficiency anaemia

et al. 2015

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Section: Discussionsupporting

confidence: 92%

“…IDA subjects had more immature reticulocytes than β-TT, suggesting a more enhanced erythropoietic activity, similar to the results reported by Noronha and Grotto11 and Urrechaga et al 14 18. However, consistent with previous reports,11 12 14 the absolute number of reticulocytes was lower in patients with IDA.…”

Section: Discussionsupporting

confidence: 89%

Reticulocyte parameters of delta beta thalassaemia trait, beta thalassaemia trait and iron deficiency anaemia

et al. 2015

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“…Few studies comprised only carriers of α-thalassemia [78,87,123] or α-and δβ-thalassemia [124]. The overall picture that emerges from these studies is that all discriminant indices perform better in β-than in α-thalassemia, even if only microcytic α-thalassemia carriers were included [35,38,61,71,98].…”

Section: Thalassemia Typesmentioning

confidence: 99%

Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a meta-analysis

Hoffmann

Urrechaga

Aguirre

2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: More than 40 mathematical indices have been proposed in the hematological literature for discriminating between iron deficiency anemia and thalassemia trait in subjects with microcytic red blood cells (RBCs). None of these discriminant indices is 100% sensitive and specific and also the ranking of the discriminant indices is not consistent. Therefore, we decided to conduct the first meta-analysis of the most frequently used discriminant indices. Methods: An extensive literature search yielded 99 articles dealing with 12 indices that were investigated five or more times. For each discriminant index we calculated the diagnostic odds ratio (DOR) and summary ROC analysis was done for comparing the performance of the indices. Results:The ratio of microcytic to hypochromic RBCs (M/H ratio) showed the best performance, DOR = 100.8. This was significantly higher than that of all other indices investigated. The RBC index scored second (DOR = 47.0), closely followed by the Sirdah index (DOR = 46.7) and the Ehsani index (DOR = 44.7). Subsequently, there was a group of four indices with intermediate and three with lower DOR. The lowest performance (DOR = 6.8) was found for the RDW (Bessman index). Overall, the indices performed better for adults than for children.

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“…18 Selain karena defisiensi besi, hal yang menyebabkan sel darah merah menjadi mikrositik hipokrom adalah talasemia dan anemia sideroblastik. 20 Remaja obesitas berisiko mengalami anemia defisiensi besi karena kurangnya asupan besi 5 dan meningkatnya kebutuhan besi. 9 Obesitas juga berkaitandengan low-grade inflammation.…”

Section: Diskusiunclassified

Iron Intake, Hemoglobin Level, and Red Blood Cell Indices in Adolescents with Obesity

Aviyani¹,

Megawati²,

Susannah³

2018

Journal of Medicine and Health

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Obesity is a condition of excess and abnormal fat accumulation. Obese adolescents are at greater risk of developing iron deficiency anemia with microcytic hypochromic red blood cells (RBC). Iron deficiency in obesity relates to low iron intake, abnormal iron absorption, and increased iron utilization. The aim of this study was to determine iron intake, hemoglobin level, and RBC indices in faculty of medicine students with obesity. We used descriptive crosssectional method, involving year of 2016 students in Faculty of Medicine PadjadjaranUniversity with obesity. Pregnant women and students with previous history of thallasemia or anemia were excluded. Iron intake was assessed using Food Frequency Questionnaire. Hemoglobin level and RBC indices were measured in Hasan Sadikin General Hospital. Iron intake of male subjects were adequate in 62,5% subjects and low in 37,5% subjects. Iron intake in female subjects were adequate in 20% subjects and low in 80% subjects. Male hemoglobin level were normal and 20% of female subjects had anemia. All male subjects were normochrom normocytic, 40% female subjects were hypochrom microcytic.

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Differential diagnosis of microcytic anemia: the role of microcytic and hypochromic erythrocytes

Abstract: Overall, the microcytic to hypochromic ratio as measured in CELL-DYN Sapphire performed equally well as the Green-King index in identifying thalassemia carriers, but with higher sensitivity, making it a quick and inexpensive screening tool.

Cited by 28 publications

References 22 publications

Reticulocyte parameters of delta beta thalassaemia trait, beta thalassaemia trait and iron deficiency anaemia

Reticulocyte parameters of delta beta thalassaemia trait, beta thalassaemia trait and iron deficiency anaemia

Discriminant indices for distinguishing thalassemia and iron deficiency in patients with microcytic anemia: a meta-analysis

Iron Intake, Hemoglobin Level, and Red Blood Cell Indices in Adolescents with Obesity

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