Differential associations of age and Alzheimer's disease with sleep and rest-activity rhythms across the adult lifespan

Park, Jee Eun; Lee, Yu Jin; Byun, Min Soo; Yi, Dahyun; Lee, Jun Ho; Jeon, So Yeon; Hwang, Jeong Yeon; Yoon, Heenam; Choe, Young Min; Kim, Yu Kyeong; Shin, Seong A.; Suk, Hye Won; Lee, Dong Hoon

doi:10.1016/j.neurobiolaging.2021.01.006

Cited by 14 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding the sex difference, Nebel et al suggested that the increased risk of AD in women may be attributed to a relative lack of some protective factors, such as estrogen deficiency of post-menopausal women, with increased vulnerability to AD pathology [ 81 ]. Regarding age, AD pathology including intracellular neurofibrillary tangles and extracellular senile plaques is worse with advanced age in AD patients [ 1 , 82 ]. Regarding education, neuroimaging studies revealed that education level is positively associated with brain reserves including regional cortical thickness [ 83 ] and white and gray matter volume [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings

et al. 2022

View full text Add to dashboard Cite

Polysomnography (PSG) studies of sleep changes in Alzheimer’s disease (AD) have reported but not fully established the relationship between sleep disturbances and AD. To better detail this relationship, we conducted a systematic review and meta-analysis of reported PSG differences between AD patients and healthy controls. An electronic literature search was conducted in EMBASE, MEDLINE, All EBM databases, CINAHL, and PsycINFO inception to Mar 2021. Twenty-eight studies were identified for systematic review, 24 of which were used for meta-analysis. Meta-analyses revealed significant reductions in total sleep time, sleep efficiency, and percentage of slow-wave sleep (SWS) and rapid eye movement (REM) sleep, and increases in sleep latency, wake time after sleep onset, number of awakenings, and REM latency in AD compared to controls. Importantly, both decreased SWS and REM were significantly associated with the severity of cognitive impairment in AD patients. Alterations in electroencephalogram (EEG) frequency components and sleep spindles were also observed in AD, although the supporting evidence for these changes was limited. Sleep in AD is compromised with increased measures of wake and decreased TST, SWS, and REM sleep relative to controls. AD-related reductions in SWS and REM sleep correlate with the degree of cognitive impairment. Alterations in sleep EEG frequency components such as sleep spindles may be possible biomarkers with relevance for diagnosing AD although their sensitivity and specificity remain to be clearly delineated. AD-related sleep changes are potential targets for early therapeutic intervention aimed at improving sleep and slowing cognitive decline.

show abstract

Section: Discussionmentioning

confidence: 99%

Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Our results show that 8 hours of sleep is associated with smaller relative regional brain volumes and thinner cortex throughout adult life. Previous research has established associations between long sleep and poorer brain 36 , cognitive 26,27,35,39,63 and somatic health 64 , which often are ascribed to underlying comorbidities 3,15,64 . In the present analyses we attempted to address this by controlling for somatic (BMI), mental (symptoms of depression) and social (SES) factors.…”

Section: Sleep Duration and The Brain Through Adult Lifementioning

confidence: 99%

Sleep duration and brain structure – phenotypic associations and genotypic covariance

Fjell

Sørensen

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

The question of how much sleep is best for the brain attracts scientific and public interest, and there is concern that insuficient sleep leads to poorer brain health. However, it is unknown how much sleep is sufficient and how much is too much. We analyzed 51,295 brain magnetic resonnance images from 47,039 participants, and calculated the self-reported sleep duration associated with the largest regional volumes and smallest ventricles relative to intracranial volume (ICV) and thickest cortex. 6.8 hours of sleep was associated with the most favorable brain outcome overall. Critical values, defined by 95% confidence intervals, were 5.7 and 7.9 hours. There was regional variation, with for instance the hippocampus showing largest volume at 6.3 hours. Moderately long sleep (> 8 hours) was more strongly associated with smaller relative volumes, thinner cortex and larger ventricles than even very short sleep (< 5 hours), but effect sizes were modest. People with larger ICV reported longer sleep (7.5 hours), so not correcting for ICV yielded longer durations associated with maximal volume. Controlling for socioeconomic status, body mass index and depression symptoms did not alter the associations. Genetic analyses showed that genes related to longer sleep in short sleepers were related to shorter sleep in long sleepers. This may indicate a genetically controlled homeostatic regulation of sleep duration. Mendelian randomization analyses did not suggest sleep duration to have a causal impact on brain structure in the analyzed datasets. The findings challenge the notion that habitual short sleep is negatively related to brain structure.

show abstract

“…Additionally, the researchers found that aging was associated with several circadian rest-activity parameters independent of preclinical Alzheimer's disease pathology, especially in men. Another study performed in the Republic of Korea demonstrated that participants with preclinical Alzheimer's disease present with an earlier circadian phase upon actigraphy [26]. In this study, the researchers suggested that preclinical Alzheimer's disease made the effects of age-associated phase advance more prominent.…”

Section: Rest-activity Pattern and Circadian Phase Alterations In Preclinical Alzheimer's Disease Or Mild Cognitive Impairmentmentioning

confidence: 64%

Rest-Activity Pattern and Circadian Phase Alterations Across the Alzheimer’s Disease Clinical Spectrum

Roh

Son

2021

Chronobiol Med

View full text Add to dashboard Cite

Actigraphy-derived locomotor activity recordings are novel and critical tools for evaluating rest-activity pattern and circadian phase in humans. We conducted a narrative review assessing rest-activity pattern and circadian phase alterations within various stages of Alzheimer’s disease, in consideration of the reciprocal associations between neurodegeneration and circadian rhythm disruption in patients with Alzheimer’s disease. The goal of this review was to characterize possible associations between circadian rhythm disruption and neurodegeneration in Alzheimer’s disease. To the best of our knowledge, only two studies have assessed rest-activity pattern and circadian phase alterations in the preclinical Alzheimer’s disease stage and the results of the studies were inconsistent. Several studies have evaluated rest-activity pattern and circadian phase alterations in patients with Alzheimer’s dementia. The most replicated findings were delayed phase and increased activity fragmentation, represented as increased intra-daily variability. Unfortunately, many studies performed in dementia patients have not examined neuroimaging biomarkers or structured neuropsychological tests, thus limiting the specification of dementia clinical diagnoses. Future studies should consider a more comprehensive evaluation of various clinical and biomarker characteristics in patients with dementia or Alzheimer’s disease.

show abstract

Differential associations of age and Alzheimer's disease with sleep and rest-activity rhythms across the adult lifespan

Cited by 14 publications

References 39 publications

Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings

Sleep in Alzheimer’s disease: a systematic review and meta-analysis of polysomnographic findings

Sleep duration and brain structure – phenotypic associations and genotypic covariance

Rest-Activity Pattern and Circadian Phase Alterations Across the Alzheimer’s Disease Clinical Spectrum

Contact Info

Product

Resources

About