Differential Actions of Chlordiazepoxide and Oxazepam on Hostility

The effects of diazepam on human self-aggressive behavior

“…For example, some benzodiazepines have been shown to elicit other-directed aggression in human laboratory studies (Ben Porath and Taylor 2002;Berman and Taylor 1995;Gardos et al 1968;Weisman et al 1998;Wilkinson 1985), which is consistent with case reports (Bond 1998;Dietch and Jennings 1988;Hall and Zisook 1981). Laboratory paradigms provide a high degree of internal validity and allow cause-and-effect relationships to be examined, features not associated with case and archival studies.…”

Differential effects of oxazepam and lorazepam on aggressive responding

“…Chlordiazepoxide but not oxazepam has been shown to increase hostility in a group setting after a frustrating stimulus is introduced (Gardos et al 1968;Salzman et al 1974;Kochansky et al 1975Kochansky et al , 1977. Diazepam has been shown to increase hostility in a group of females (McDonald 1967) and to increase behavioural aggression on the competitive reaction time task utilising shocks (Wilkinson 1987).…”

Chlordiazepoxide (Librium

“…In humans, literally hundreds of reports have appeared documenting its clinical efficacy under all varieties of settings for combating mild to severe anxiety and related symptoms. Particularly suggestive of possible effects on social behavior are the results of an investigation (Gardos et al, 1968) corroborating through psychological tests its tendency as it reduces anxiety to bring on an irritability, an overreaction to minor annoyances, and a lashing out at others when such appears subjectively justified but would otherwise be restrained.…”