Different roles of catecholaminergic and serotoninergic neurons of the medial forebrain bundle on male rat sexual behavior

Rodrı́guez, Manuel; Castro, Rafael; Hernández, Guadalberto; Mas, Manuel

doi:10.1016/0031-9384(84)90005-2

Cited by 44 publications

(5 citation statements)

References 66 publications

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“…The current investigation also supports previous suggestions that serotonin and catecholamines interact antagonistically in the mediation of some behaviors (Brodie and Shore 1957;Dickinson and Curzon 1983;Nishikawa et al 1983 ;Green 1984;Rodriquez et al 1984;Trulson and Crisp 1984;Yamamoto and Freed 1984). While many other transmitter systems besides the monoamines are likely to influence these behaviors, their contributions cannot be assessed with the present data.…”

Section: Discussionsupporting

confidence: 86%

Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems

Raleigh

1987

Psychopharmacology

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In previous studies tryptophan and 5-hydroxy-tryptophan (5-HTP) treatments produced opposite effects on aggression and vigilance and differing effects on eating and locomoting in vervet monkeys. This study examined the effects of the serotonin reuptake inhibitor fluoxetine, and the catecholamine reuptake inhibitor desmethylimipramine (DMI) on tryptophan and 5-HTP induced behavioral changes. Thirty-two adult males from 16 different social groups were studied. Tryptophan (10, 20, and 40 mg/kg/day) produced dose-dependent reductions in aggression, vigilance, and locomotion and increases in eating. In contrast, 5-HTP (20, 40, and 80 mg/kg/day) increased aggression and vigilance and did not affect locomotion or eating. Fluoxetine (0.5, 1.0, and 2.0 mg/kg/day) produced effects identical to tryptophan while DMI (1.5, 3.0, and 6.0 mg/kg/day) resulted in dose-dependent increases in aggression, vigilance, and locomotion, and decrements in eating. When combined with tryptophan, fluoxetine augmented and DMI diminished the effects of tryptophan on all behaviors. Fluoxetine decreased and DMI increased the effects of 5-HTP on aggression and vigilance. Thus concurrent DMI enhanced and concurrent fluoxetine reduced the differences between 5-HTP and tryptophan. These results suggest that 5-HTP's effects on catecholaminergic systems may underlie the differing behavioral effects of tryptophan and 5-HTP on behavior in a species closely related to humans.

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Section: Discussionsupporting

confidence: 86%

Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems

Raleigh

1987

Psychopharmacology

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“…The serotonergic system also plays an important role in SA; serotonin facilitates sexual activity in rats [28, 29]as well as in human beings [30]. Selective serotonin reuptake inhibitors have an inhibitory action on orgasm in human beings [31, 32, 33]and on ejaculatory functions in some animals [34, 35, 36, 37]. There is evidence indicating that the effect of serotonin on SA differs according to the activation of different types of serotonin receptors [29], and the impact of serotonin on SA may therefore be very complex.…”

Section: Discussionmentioning

confidence: 99%

Poststroke Emotional Incontinence and Decreased Sexual Activity

Choi-Kwon¹,

Kim²

2002

Cerebrovasc Dis

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Background: Although poststroke depression has been shown to be related to decreased sexual activity (SA), the relationship between poststroke emotional incontinence (EI) and SA has not been properly investigated. Methods: We examined 70 nondepressed, sexually active patients with first-ever stroke approximately 3 months after stroke and conducted a follow-up interview approximately 2 years after stroke in 55 of them. EI (excessive/inappropriate laughing/crying) and SA (libido, coital frequency, erectile function) were assessed with the use of a standardized questionnaire. Results: Of these 70 patients, 24 (34%) had EI 3 months after stroke, which had resolved 2 years after stroke. Libido, coital frequency and erectile function were reported to have declined in 49, 65 and 26% of the patients, respectively, 3 months after stroke, and in 44, 49 and 20% of the patients 2 years after stroke. Multivariate analyses showed that low coital frequency before stroke (CFBS) was significantly (p < 0.05) related to decreased poststroke coital frequency, while the presence of EI (p < 0.05) and low CFBS (p < 0.05) was significantly associated with decreased erectile function 3 months after stroke. Two years after stroke, the presence of EI 3 months after stroke was significantly related to decreased libido, coital frequency and erectile function (p < 0.05 each). Age, gender, laterality of stroke, Barthel Index score, motor dysfunction and the presence of hypertension and diabetes mellitus were not independently related to SA 3 months and 2 years after stroke. Conclusion: The presence of EI is a factor related to decreased poststroke SA, more so in chronic than in subacute stages.

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“…Intracranial injection of 5-HT neurotoxin enhanced the behavior (21,25), conversely 5-HT injection suppressed it (22, 26). Treatment ofpCPA, a 5-HT synthesis inhibitor, which caused severe decrease of brain 5-HT content to 10 to 20% of the normal value (27)(28)(29)(30), resulted in drastic facilitation of masculine sexual behavior in male rats (3 1-33).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to these facilitatory influences, there is a considerable body of evidence suggesting that the serotonin (5-HT) neuron system exerts an inhibitory influence on display of masculine sexual behavior (21,22). Both the MPO and LS have been reported to be innervated by 5-HT fibers from the midbrain raphe nuclei (23,24).…”

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confidence: 99%

P‐chlorophenylallanine Facilitates Copulatory Behavior in Septal Lesioned but not in Preoptic Lesioned Male Rats

Kondo¹,

Yamanouchi²,

Arai³

1993

J Neuroendocrinology

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Effects of p-chlorophenylalanine (pCPA), synthesis-inhibitor of serotonin, on copulatory behavior were examined in testosterone (T) treated castrated male rats with lesions in the lateral septum (LSL) or in the medial preoptic area (MPOL). Three weeks after the operation, all animals were chronically treated with T using silastic capsules. Behavioral tests were carried out at 10 and 20 days after the implantation of T. In half of the males in each group, 100 mg/Kg pCPA was injected daily for 4 days before each test. The other half of the group was injected with saline instead of pCPA. In saline-treated groups, the males with LSL or MPOL showed extremely lower frequencies of mount and intromission than control males without brain surgery. pCPA-treated control males showed higher copulatory activities than saline-treated control males. In contrast, even after the treatment with pCPA, severe impairment of sexual behavior was observed in males with MPOL. On the other hand, pCPA-treated LSL males displayed copulatory behavior more frequently than saline-treated LSL males. These results agreed with previous reports that both the medial preoptic area and the lateral septum play an excitatory role in regulating male sexual behavior. Furthermore, these results suggest that the inhibitory function of serotonergic neurons govern dependently on the function of the medial preoptic area, but independently on the function of the lateral septum.

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Different roles of catecholaminergic and serotoninergic neurons of the medial forebrain bundle on male rat sexual behavior

Cited by 44 publications

References 66 publications

Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems

Differential behavioral effects of tryptophan and 5-hydroxytryptophan in vervet monkeys: influence of catecholaminergic systems

Poststroke Emotional Incontinence and Decreased Sexual Activity

P‐chlorophenylallanine Facilitates Copulatory Behavior in Septal Lesioned but not in Preoptic Lesioned Male Rats

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